A5048337681- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Neurological diseases and metabolism
- DNA Repair Mechanisms
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- RNA regulation and disease
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Heat shock proteins research
- Lipoproteins and Cardiovascular Health
- Tryptophan and brain disorders
- Amyotrophic Lateral Sclerosis Research
- Autism Spectrum Disorder Research
- Polyomavirus and related diseases
National Taiwan Normal University
2016-2025
Chang Gung University
2007-2016
Chang Gung Memorial Hospital
2007-2016
Linkou Chang Gung Memorial Hospital
2015
Mitsubishi Corporation (Japan)
2015
Barber-Nichols (United States)
1992
University at Buffalo, State University of New York
1988
Roswell Park Comprehensive Cancer Center
1986
Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain GBA ethnically diverse group disease.Sixteen centers participated our international, collaborative study: five from Americas, six Europe, two Israel, and three Asia. Each center genotyped standard DNA panel permit comparison genotyping results across centers. Genotypes phenotypic...
Abstract Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence leucine‐rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers Taiwan Singapore demonstrates Lrrk2 R1628P increases (odds ratio, 1.84; 95% confidence interval, 1.20–2.83; p = 0.006). Haplotype analysis...
Lactulose, as a prebiotic, can be utilized by human gut microbiota and stimulate their growth. Although modulation has become an emerging approach to manage many diseases achieved the administration of prebiotics, fewer investigations have been carried out on therapeutic mechanism lactulose. Two trehalose analogs, lactulose melibiose, were identified having neuroprotective effect in polyglutamine Parkinson disease models. In this study, we examined melibiose mouse primary hippocampal...
Abstract Background As gene‐targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction the estimated number subjects with monogenic PD worldwide currently represented in literature availability clinical data trial‐ready cohorts limited. Objective The objectives to (1) establish an international cohort affected unaffected individuals PD‐linked variants;...
Misfolding and accumulation of amyloid-β (Aβ) in the brains patients with Alzheimer's disease (AD) lead to neuronal loss through various mechanisms, including downregulation eukaryotic elongation factor 2 (EEF2) protein synthesis signaling. This study investigated neuroprotective effects indole coumarin derivatives on Aβ folding EEF2 signaling using SH-SY5Y cells expressing Aβ-green fluorescent (GFP) reporter. Among tested compounds, two (NC009-1, -6) (LM-021, -036) effectively reduced...
Amyloid β (Aβ) plays a major role in the neurodegeneration of Alzheimerâs disease (AD). The accumulation misfolded Aβ causes oxidative stress and inflammatory damage leading to apoptotic cell death. Traditional Chinese herbal medicine (CHM) has been widely used treating neurodegenerative diseases by reducing neuroinflammation. We examined neuroprotective effect formulated CHM Shaoyao Gancao Tang (SG-Tang, made Paeonia lactiflora Glycyrrhiza uralensis at 1:1 ratio) AD mouse models. In...
Alzheimer's disease (AD) is a neurodegenerative with progressive memory loss and the cognitive decline. AD mainly caused by abnormal accumulation of misfolded amyloid β (Aβ), which leads to neurodegeneration via number possible mechanisms such as down-regulation brain-derived neurotrophic factor-tropomyosin-related kinase B (BDNF-TRKB) signaling pathway. 7 ,8-Dihydroxyflavone (7,8-DHF), TRKB agonist, has demonstrated potential enhance BDNF-TRKB pathway in various diseases. To expand capacity...
Journal Article Correlation of HER-2/neu Amplification With Expression and Other Prognostic Factors in 1103 Breast Cancers Get access Daniel R. Ciocca, Ciocca Department Medicine, Division Medical Oncology, The University Texas Health Science Center at San Antonio, Tex. Present address: D. Laboratorio de Reproduccion y Lactancia, LARLAC, C.C. 855, 5500 Mendoza, Argentina. Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank K. Fujimura, Fujimura Nichols...
Background Chronic hyperglycemia-associated inflammation plays critical roles in disease initiation and the progression of diabetic complications, including Alzheimer's (AD). However, association chronic hyperglycemia with acute central nervous system AD still needs to be elucidated. In addition, recent evidence suggests that Glucagon-like peptide-1 receptor (GLP-1R) protects against neuronal damage brain. Therefore, neuroprotective effects GLP-1R agonist exendin-4 (EX-4)...
Abstract Background Aggregation of misfolded amyloid β (Aβ) in senile plaques causes oxidative stress and neuronal death Alzheimer's disease (AD). Compounds possessing antiaggregation antioxidant properties are promising candidate compounds for AD treatment. Methods We examined the potential synthetic derivatives licochalcone A coumarin inhibiting Aβ aggregation, scavenging reactive oxygen species (ROS), providing neuroprotection by using biochemical assays Tet‐On Aβ‐GFP 293/SH‐SY5Y cell...
Neuroinflammation and oxidative stress have been emerging as important pathways contributing to Parkinson's disease (PD) pathogenesis. In PD brains, the activated microglia release inflammatory factors such interleukin (IL)-β, IL-6, tumor necrosis factor (TNF)-α, nitric oxide (NO), which increase mediate neurodegeneration. Using 1-methyl-4-phenylpyridinium (MPP+)-activated human microglial HMC3 cells sub-chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD,...
Alzheimer's disease (AD), probably caused by abnormal accumulation of β-amyloid (Aβ) and aberrant phosphorylation tau, is the most common cause dementia among older people. Generation patient-specific neurons induced pluripotent stem cell (iPSC) technology facilitates exploration features in live human from AD patients. In this study, we generated iPSCs two familial patients carrying a heterozygous D678H mutation APP gene (AD-iPSCs). The derived our AD-iPSCs demonstrated intracellular...
Hyperphosphorylation and aggregation of the microtubule binding protein tau is a neuropathological hallmark Alzheimer's disease/tauopathies. Tau neurotoxicity provokes alterations in brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase B (TRKB)/cAMP-response-element (CREB) signaling to contribute neurodegeneration. Compounds activating TRKB may therefore provide beneficial effects tauopathies. LM-031, coumarin derivative, has demonstrated potential improve BDNF neuronal cells...
The efficiency of simian virus 40 (SV40) DNA replication is dependent on the structural organization regulatory region. enhancing effect G + C-rich 21-base-pair (bp) repeats SV40 position and dose to some extent orientation dependent. inverted about 50% as effective normal 21-bp repeat Movement region 180 or 370 bp upstream ori sequence abolishes its effect, whereas no detected if placed downstream sequence. dose-dependent enhancement first described in single transfection by Bergsma et al....
Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant inherited disorder characterized by degeneration of spinocerebellar tracts and selected brainstem neurons owing to the expansion a CAG repeat human TATA-binding protein (hTBP) gene. To gain insight into pathogenesis this hTBP mutation, we generated transgenic mice with mutant gene driven Purkinje specific (Pcp2/L7) promoter. Mice expanded allele developed within 2-5 months. Behavioral analysis L7-hTBP showed reduced fall latency...
Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant cerebellar caused by the expansion of polyglutamine (polyQ) within TATA box-binding protein (TBP). Previous studies have shown that polyQ-expanded TBP forms neurotoxic aggregates and alters downstream genes. However, how expanded polyQ tracts affect function link between dysfunctional SCA17 not clearly understood. In this study, we generated novel Drosophila models for recapitulate pathological features such as aggregate...
Misfolded tau proteins induce accumulation of free radicals and promote neuroinflammation by activating microglia‐releasing proinflammatory cytokines, leading to neuronal cell death. Traditional Chinese herbal medicines (CHMs) have been widely used in clinical practice treat neurodegenerative diseases associated with oxidative stress neuroinflammation. This study examined the neuroprotection effects formulated CHMs Bai‐Shao (made Paeonia lactiflora ), Gan‐Cao Glycyrrhiza uralensis Shaoyao...
Parkinson's disease (PD) is a common neurodegenerative characterized by progressive loss of dopaminergic (DAergic) neurons in ventral brain. A disaccharide trehalose has demonstrated the potential to mitigate DAergic models for PD. However, rapidly hydrolyzed into glucose trehalase intestine, limiting its clinical practice. Here we investigated neuroprotective potentials two trehalase-indigestible analogs, lactulose and melibiose, sub-chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...