A5071249832- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Lysosomal Storage Disorders Research
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neurological diseases and metabolism
- Multiple Sclerosis Research Studies
- Ginkgo biloba and Cashew Applications
- RNA regulation and disease
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Effects of Vibration on Health
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Cellular transport and secretion
- Optical Imaging and Spectroscopy Techniques
- Nuclear Receptors and Signaling
- Assistive Technology in Communication and Mobility
- Diabetic Foot Ulcer Assessment and Management
- Gait Recognition and Analysis
- Banana Cultivation and Research
Tel Aviv Sourasky Medical Center
2016-2025
Tel Aviv University
2016-2025
Zero to Three
2025
Academic College of Tel Aviv-Yafo
2022-2024
Foundation for Medical Research
2024
John Wiley & Sons (United States)
2023
Institute for Neurodegenerative Disorders
2017-2022
Albert Einstein College of Medicine
2021-2022
Mount Sinai Beth Israel
2013-2022
Columbia University Irving Medical Center
2014-2022
Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain GBA ethnically diverse group disease.Sixteen centers participated our international, collaborative study: five from Americas, six Europe, two Israel, and three Asia. Each center genotyped standard DNA panel permit comparison genotyping results across centers. Genotypes phenotypic...
Background.Executive function (EF) deficits may increase fall risk, even among older adults with no overt cognitive impairment. Indeed, the effects of dual tasking (DT) on gait, a challenge to executive control, are more exaggerated in persons history falls. Prospective evidence is, however, lacking.
Background Recent findings suggest that executive function (EF) plays a critical role in the regulation of gait older adults, especially under complex and challenging conditions, EF deficits may, therefore, contribute to fall risk. The objective this study was evaluate if reduced is risk factor for future falls over course 5 years follow-up. Secondary objectives were assess whether single dual task walking abilities, an alternative window into EF, associated with Methodology/Main Results We...
Training of the lower extremity (LE) using a robot coupled with virtual environments has shown to transfer improved overground locomotion. The purpose this study was determine whether training LE movements locomotion greater environment or alone.A single, blind, randomized clinical trial conducted. Eighteen individuals poststroke participated in 4-week protocol. One group trained reality (VR) system and other alone. Outcome measures were temporal features gait measured laboratory setting...
Previous studies have demonstrated that the performance of a secondary task during walking alters gait.This study investigated effects prioritization on in young and older adults to evaluate "default" scheme used, flexibility alter cortical resources allocated gait cognitive task, any age-associated changes these abilities.A cross-sectional explicitly altered focus attention was used investigate who were healthy.Gait speed variability evaluated (n=40) (n=17) healthy, both usual under 3...
Accumulating evidence suggests that gait is influenced by higher order cognitive and cortical control mechanisms. Recently, several studies used functional near infrared spectroscopy (fNIRS) to examine brain activity during walking, demonstrating increased oxygenated hemoglobin (HbO2) levels in the frontal cortex walking while subjects completed a verbal task. It is, however, still unclear whether this increase activation was related verbalization, if response specific gait, or it would also...
Background. Gait is influenced by higher order cognitive and cortical control mechanisms. Functional near infrared spectroscopy (fNIRS) has been used to examine frontal activation during walking in healthy older adults, reporting increased oxygenated hemoglobin (HbO2) levels dual task (DT), compared with usual walking. Objective. To investigate the role of lobe DT obstacle negotiation, adults patients Parkinson’s disease (PD). Methods. Thirty-eight (mean age 70.4 ± 0.9 years) 68 PD 71.7 1.1...
The step-by-step determination of the spatio-temporal parameters gait is clinically relevant since it provides an estimation variability specific patterns associated with frequent geriatric syndromes. In recent years, several methods, based on use magneto-inertial units (MIMUs), have been developed for temporal parameters. However, most them were applied to healthy subjects and/or a single pathologic population. Moreover, spatial in populations rarely estimated using MIMUs. validity suitable...
The traditional evaluation of gait in the laboratory during structured testing has provided important insights, but is limited by its "snapshot" character and observation an unnatural environment. Wearables enable monitoring real-world environments over a week. Initial findings show that in-lab measures differ. As step towards better understanding these gaps, we directly compared usual-walking (UW) dual-task walking (DTW) to daily-living gait.In-lab features (e.g., speed, regularity, stride...
To study the possible association of founder mutations in lysosomal storage disorder genes HEXA, SMPD1, and MCOLN1 (causing Tay-Sachs, Niemann-Pick A, mucolipidosis type IV diseases, respectively) with Parkinson disease (PD).Two PD patient cohorts Ashkenazi Jewish (AJ) ancestry, that included a total 938 patients, were studied: cohort 654 patients from Tel Aviv, replication 284 New York. Eight AJ analyzed. The frequencies these compared to control groups large published undergoing prenatal...
ABSTRACT Background Reduced arm swing is a well‐known clinical feature of Parkinson's disease (PD), often observed early in the course disease. We hypothesized that subtle changes and axial rotation may also be detectable prodromal phase. Objective The purpose this study was to evaluate relationship between LRRK2‐ G2019S mutation, swing, healthy nonmanifesting carriers noncarriers mutation patients with PD. Methods A total 380 participants (186 controls 194 PD patients) from 6 sites...
Recent work has demonstrated that fall risk can be attributed to cognitive as well motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while forward. Pilot studies suggest a multi-modal intervention combines treadmill training target function virtual reality obstacle course address the components of may used successfully motor-cognitive interactions are fundamental for reduction. The proposed randomized...
Falls are associated with gait impairments in older adults (OA) and Parkinson's disease (PD). Current approaches for evaluating falls risk based on self-report or one-time assessment may be suboptimal. Wearable technology allows to measured continuously free-living conditions. The aim of this study was explore generic specific associations fallers nonfallers without PD. Two hundred seventy-seven (155 PD, 122 OA) who fell twice more the previous 6 months 65 (15 50 were tested. Free-living...
Estimates of the penetrance LRRK2 G2019S vary widely (24%-100%), reflective differences in ascertainment, age, sex, ethnic group, and genetic environmental modifiers.The kin-cohort method was used to predict 2,270 relatives 474 Ashkenazi Jewish (AJ) Parkinson disease (PD) probands Michael J. Fox AJ Consortium New York Tel Aviv, Israel. Patients with PD were genotyped for mutation at least 7 founder GBA mutations. carriers excluded. A validated family history interview, including age onset...
Abstract To test for an association between the LRRK2 ‐G2019S mutation and gait, we studied 52 first‐degree relatives of patients with Parkinson's disease (PD) who carry this mutation. An accelerometer quantified gait during usual‐walking, fast‐walking, dual‐tasking. Noncarriers (n = 27) carriers 25) were similar respect to age, gender, height, speed all conditions. During dual‐tasking variability amplitude dominant peak signal significantly altered among carriers. These findings support...