A5006153222- Parasite Biology and Host Interactions
- S100 Proteins and Annexins
- Mollusks and Parasites Studies
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Helminth infection and control
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Characterization and Applications of Magnetic Nanoparticles
- Advancements in Transdermal Drug Delivery
- Parasites and Host Interactions
- Plasmonic and Surface Plasmon Research
- Electromagnetic Fields and Biological Effects
- Gold and Silver Nanoparticles Synthesis and Applications
- Hedgehog Signaling Pathway Studies
- Solid State Laser Technologies
- Metallic Glasses and Amorphous Alloys
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Luminescence Properties of Advanced Materials
- Magnetic properties of thin films
- Micro and Nano Robotics
- Zebrafish Biomedical Research Applications
- Gut microbiota and health
Karolinska Institutet
2025
Chang Gung University
2013-2024
Linkou Chang Gung Memorial Hospital
2020-2024
Institute of Molecular Biology, Academia Sinica
2021-2023
Academia Sinica
2021-2023
Chang Gung University of Science and Technology
2017-2022
National Yang Ming Chiao Tung University
2014-2021
Mackay Memorial Hospital
2011-2019
Life University
2015
Langfang Normal University
2015
An advanced laser headlight module (LHM) employing highly reliable glass phosphor is demonstrated. The novel glass-based YAG phosphor-converter layers fabricated by low-temperature of 750°C exhibited better thermal stability. LHM consisted a 5 × 1 blue diode array, an aspherical lens, layer with aluminum dissipation substrate, and dichroic filter to allow pass light reflect yellow light. array was packaged five lasers having optical power 1.2 W per laser. total output 6 W, luminous flux 1860...
Neutrophil infiltration plays a significant pathological role in inflammatory diseases. NADPH oxidase type 2 (NOX2) is respiratory burst that generates large amounts of superoxide anion (O2•−) and subsequent other reactive oxygen species (ROS). NOX2 an emerging therapeutic target for treating neutrophilic Herein, we show 4-[(4-(dimethylamino)butoxy)imino]-1-methyl-1H-benzo[f]indol-9(4H)-one (CYR5099) acts as inhibitor exerts protective effect against complete Freund's adjuvant (CFA)-induced...
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation SMN1 known to cause SMA, restoring SMN protein levels via antisense oligonucleotide treatment effective for ameliorating symptoms. However, this approach hindered exorbitant costs, invasive procedures, poor responses some patients. Here, we seek circumvent these hurdles identifying reliable biomarkers that could predict...
The incidence of autoimmune diseases is increasing in developed countries, possibly due to the modern Western diet and lifestyle. We showed earlier that polysaccharides derived from medicinal fungus Hirsutella sinensis produced anti-inflammatory, anti-diabetic anti-obesity effects by modulating gut microbiota abundance commensal Parabacteroides goldsteinii mice fed with a high-fat diet. examined prebiotics, H. polysaccharides, probiotic, P. goldsteinii, mouse model imiquimod-induced systemic...
This paper reports on the incorporation of oleic acid (OA) within nanostructured lipid carriers (OA-NLC) to improve anti-inflammatory effects in presence albumin.NLCs produced via hot high-shear homogenization/ultrasonication were characterized terms particle size, zeta potential, and toxicity. We examined OA-NLC neutrophil activities. Dermatologic therapeutic potential was also elucidated by using a murine model leukotriene B4-induced skin inflammation.In albumin, but not free OA inhibited...
Terrestrial quadrupeds actively stabilize dorsal-side-up orientation of the body in space due to activity postural control system. Supraspinal influences, including those from reticular formation, play a crucial role operation this However, specific molecularly identified populations neurons posture remains unknown. The aim present study was reveal CaMKIIa (CaMKIIa-RNs) located caudal medulla posture. For purpose, effects unilateral chemogenetic activation/inactivation CaMKIIα-RNs on...
Abstract In this study, we sought to enhance the cutting properties of various blades by coating them with Zr- and Fe-based thin film metallic glasses (TFMGs) a thickness 234–255 nm via sputter deposition. oil-repellency/sliding tests on kitchen blades, sliding angle friction forces were as follows: bare (31.6°) (35 µN), Ti-coated (20.3°) (23.7 Z-TFMG coated (16.2°) (19.2 µN). Comparisons conducted those Teflon (a low-friction material commonly used for microtome blades). We also found that...
Breast reconstruction with a transverse rectus abdominis myocutaneous (TRAM) flap plus an implant has been proposed as option for women thin body habitus who do not have sufficient abdominal tissue to permit TRAM alone. The standard autologous reconstructive procedure in these is combined latissimus dorsi and breast implant. We reviewed our experience performing flap/implant compare complication rates aesthetic outcomes between two types of reconstruction. Between 1992 1999, 88 breasts were...
To find whether low-frequency pulsed electromagnetic fields help repair larger cartilage defects with the assistance of tissue-engineered scaffolds, we tested their effect on behavior chondrocyte cells cultured chitosan films. Primary porcine chondrocytes growing films were exposed to (frequency=75 Hz; impulse width=1.3 ms; strength=1.8-3 mT) 2 hours a day for 3 weeks. The that not served as controls. For weeks, cell proliferation, viability, and expressions type II collagen...
Fish scales, which consist of type I collagen and hydroxyapatite (HA), were used to fabricate a bioabsorbable bone pin in this study. Fresh fish scales decellularized characterized provide higher biocompatibility. The mechanical properties tested, the microstructure an acellular scale was examined. growth curve myoblastic cell line (C2C12), cultured on implied biocompatibility vitro, morphology cells observed using scanning electron microscopy (SEM). A made for internal fixation femur...
Formyl peptide receptor 1 (FPR1) mediates bacterial and mitochondrial N-formyl peptides-induced neutrophil activation. Therefore, FPR1 is an important therapeutic target for drugs to treat septic or sterile inflammatory diseases. Honokiol, a major bioactive compound of Magnoliaceae plants, possesses several anti-inflammatory activities. Here, we show that honokiol exhibits inhibitory effect on binding in human neutrophils. Honokiol inhibited superoxide anion generation, reactive oxygen...