A5054470933- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis C virus research
- HIV Research and Treatment
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Diagnosis and treatment of tuberculosis
- HIV, Drug Use, Sexual Risk
- Syphilis Diagnosis and Treatment
- Amoebic Infections and Treatments
- Reproductive tract infections research
- Hepatitis Viruses Studies and Epidemiology
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Liver Disease Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Parvovirus B19 Infection Studies
- Silicon Carbide Semiconductor Technologies
- Immunodeficiency and Autoimmune Disorders
- Nail Diseases and Treatments
National Taiwan University
2016-2025
National Taiwan University Hospital
2016-2025
National Yunlin University of Science and Technology
2022-2025
Industrial Technology Research Institute
2005-2024
New York Medical College
2024
China Medical University
2014-2023
China Medical University Hospital
2014-2023
Chi Mei Medical Center
2010-2022
Weatherford College
2022
Alexandra Hospital
2022
Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for wide spectrum skin and soft tissue diseases, central nervous system infections, bacteremia, ocular other infections. M. is differentiated into 3 subspecies: subsp. abscessus, massiliense, bolletii. The 2 major subspecies, have different erm(41) gene patterns. This provides intrinsic resistance to macrolides, so the patterns lead treatment outcomes....
Background: The 2-drug regimen dolutegravir + lamivudine was noninferior to tenofovir disoproxil fumarate/emtricitabine in achieving HIV-1 RNA <50 copies/mL treatment-naive adults the 48-week primary analysis of GEMINI trials. We present results from prespecified 96-week secondary analyses. Setting: One hundred eighty-seven centers 21 countries. Methods: GEMINI-1 and GEMINI-2 are identical, double-blind phase III studies. Participants with screening ≤500,000 were randomized 1:1 once-daily...
Abstract The severe acute respiratory syndrome–associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little known about the load SARS-CoV in oral droplets. We examined specimens, including throat wash and saliva, found large amounts RNA both (9.58 x 102 5.93 106 copies/mL) saliva (7.08 103 6.38 108 from all specimens 17 consecutive probable SARS case-patients, supporting possibility transmission Immunofluorescence study showed replication...
Objectives: Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an emerging threat in ICUs worldwide, and comparative prospective studies of colistin-based combination therapies are lacking, our objective was to compare the outcomes patients with drug-resistant A. baumannii bacteremia, treated colistin-carbapenem colistin-tigecycline combinations. Design: Prospective, observational, multicenter study. Setting, Patients, Interventions: Adults bacteremia...
To assess efficacy and safety of dolutegravir (DTG) + lamivudine (3TC) vs. DTG tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in treatment-naive adults with HIV-1 the prespecified 144-week secondary analyses GEMINI-1 GEMINI-2.Identical, multicenter, phase III, randomized, non-inferiority studies (double-blind through 96 weeks).Participants RNA ≤500 000 copies/ml no major viral resistance mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside or protease inhibitors...
Thirty-one cases of severe acute respiratory syndrome (SARS) occurred after exposure in the emergency room at National Taiwan University Hospital. The index patient was linked to an outbreak a nearby municipal hospital. Three clusters were identified over 3-week period. first cluster (5 patients) and second (14 among patients, family members, nursing aids. third (12 exclusively healthcare workers. Six workers had close contact with SARS patients. others, different working patterns, indicated...
Incidence of Entamoeba histolytica infection and clinical manifestations treatment response invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before.At the National Taiwan University Hospital, medical records who received a diagnosis IA between 1994 2005 were reviewed. The incidence was serial blood stool samples from 670 264 patients, respectively, using serological specific amebic antigen assays. DNA extracted containing E. analyzed by PCR, sequenced, compared....
The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected 115 HIV-uninfected patients with syphilis who received penicillin treatment. overall rate JH was 31.5% (34.6% in HIV-infected 25.2% patients). In multivariate analysis, included high rapid plasma reagin (RPR) titers (per log(2) RPR increase, ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early (RR, 8.59; CI, 4.75-15.56),...
To evaluate the evolution of weight and lipid profiles before after switch to co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) among virally suppressed HIV-positive patients.Patients switching E/C/F/TAF between March July 2018 were included. Weight, profile (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C)), glycated hemoglobin (HbA1c) levels at 48 weeks analyzed using generalized estimating equations in...
Background Concurrent sexually transmitted infections (STIs) are common in active populations. We aimed to estimate the prevalence and coinfection rates of bacterial STIs among active, HIV-positive men who have sex with (MSM), assess potential benefits different combination treatment regimens managing concurrent STIs. Methods From September 2021 2023, MSM underwent STI testing when they had symptoms suggestive or recently acquired hepatitis C virus (HCV) infection early syphilis. The oral...
Background: Whether risk of invasive amebiasis due to Entamoeba histolytica is higher among human immunodeficiency virus (HIV)-infected persons than uninfected remains unclear, although intestinal colonization by dispar common men who have sex with men.Our objective was determine the prevalence and E in HIV-infected controls. Methods:We assessed case review 951 serologic studies 634 persons, 429 controls gastrointestinal symptoms, 178 healthy using indirect hemagglutination antibody assay.We...
Between June 1994 and February 2003, a total of 111 human immunodeficiency virus (HIV)-infected patients with chronic hepatitis B (HBV) coinfection 387 HIV-infected without HBV or C were prospectively observed to assess the impact infection on outcomes patients. After median duration observation 25 months, coinfected more likely develop (adjusted hazard ratio [AHR], 2.54; 95% confidence interval [CI], 1.69-3.82) hepatic decompensation odds [AOR], 9.94; CI, 1.89-52.35). Although similar...
Galactomannan (GM) is a heteropolysaccharide in the cell walls of most Aspergillus and Penicillium species. Cross-reactivity Cryptococcus neoformans galactoxylomannan an GM test has also been reported. In this study, we used Platelia enzyme immunoassay kit (Bio-Rad) to serum samples obtained from 48 human immunodeficiency virus (HIV)-infected patients (15 with penicilliosis [7 fungemia alone, 4 cavitary lung lesions 3 both lesions, 1 disseminated disease], 22 cryptococcosis [11 5 both,...