A5101812404- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Stress Responses and Cortisol
- Histone Deacetylase Inhibitors Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Ion channel regulation and function
- Diagnosis and Treatment of Venous Diseases
- Environmental remediation with nanomaterials
- Venous Thromboembolism Diagnosis and Management
- Aluminum Alloys Composites Properties
- Long-Term Effects of COVID-19
- Law, AI, and Intellectual Property
- Pluripotent Stem Cells Research
- Tuberculosis Research and Epidemiology
- Magnesium Oxide Properties and Applications
- Insect and Pesticide Research
- Ethics and Social Impacts of AI
Nanjing Medical University
2016-2025
Kuang Tien General Hospital
2025
Virginia Tech
2025
Third Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Chiayi Chang Gung Memorial Hospital
2021-2024
Beijing University of Technology
2020-2024
National Dong Hwa University
2023
Huanggang Normal University
2022-2023
Heriot-Watt University
2023
Contextual fear memory becomes less context-specific over time, a phenomenon referred to as contextual generalization. Overgeneralization of is core symptom post-traumatic stress disorder (PTSD), but circuit mechanisms underlying the generalization remain unclear. We show here that neural projections from anterior cingulate cortex (ACC) ventral hippocampus (vHPC) mediate in male mice. Retrieval novel context at remote time point activated cells ACC and vHPC, indicated by significantly...
Stroke usually causes prolonged or lifelong disability, owing to the permanent loss of infarcted tissue. Although a variety stem cell transplantation has been explored improve neuronal defect behavior by enhancing neuroplasticity, it remains unknown whether tissue can be reconstructed. We here cultured human cerebral organoids derived from pluripotent cells (hPSCs) and transplanted them into junction infarct core peri-infarct zone NOD-SCID mice subjected stroke. Months later, we found that...
In this paper, highly selective core–shell molecularly imprinted polymers (MIPs) of tadalafil on the surface magnetic nanoparticles (MNPs) were prepared. Three widely used functional monomers 2-(trifluoromethyl) acrylic acid (TFMAA), (AA), and methacrylic (MAA) compared theoretically as candidates for MIP preparation. MIP-coated (MIP-coated MNPs) showed large adsorption capacity, high recognition ability, fast binding kinetics tadalafil. Furthermore, because good properties, MNPs can achieve...
The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected 115 HIV-uninfected patients with syphilis who received penicillin treatment. overall rate JH was 31.5% (34.6% in HIV-infected 25.2% patients). In multivariate analysis, included high rapid plasma reagin (RPR) titers (per log(2) RPR increase, ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early (RR, 8.59; CI, 4.75-15.56),...
Stroke is a major public health concern. The lack of effective therapies heightens the need for new therapeutic targets. Mammalian brain has ability to rewire itself restore lost functionalities. Promoting regenerative repair, including neurogenesis and dendritic remodeling, may offer strategy treatment stroke. Here, we report that interaction neuronal nitric oxide synthase (nNOS) with protein postsynaptic density-95 (PSD-95) negatively controls repair after stroke in rats. Dissociating...
Narrow therapeutic window limits treatments with thrombolysis and neuroprotection for most stroke patients. Widening remains a critical challenge. Understanding the key mechanisms underlying pathophysiological events in peri-infarct area where secondary injury coexists neuroplasticity over days to weeks may offer an opportunity expanding window. Here we show that ischemia-induced histone deacetylase 2 (HDAC2) upregulation from 5 7 d after plays crucial role. In this phase, suppressing HDAC2...
Abstract Anxiety is common in patients suffering from chronic pain. Here, we report anxiety-like behaviors mouse models of pain and reveal that nNOS-expressing neurons ventromedial prefrontal cortex (vmPFC) are essential for pain-induced anxiety but not algesia, using optogenetic chemogenetic strategies. Additionally, determined excitatory projections the posterior subregion paraventricular thalamic nucleus (pPVT) provide a neuronal input drives activation vmPFC our models. Our results...
Background Stroke is a leading cause of long‐term disability worldwide. However, current therapies that promote functional recovery from stroke are limited to physical rehabilitation. No pharmacological therapy available. Thus, understanding the role histone deacetylase 2 (HDAC2) in pathophysiological process stroke‐induced loss may provide novel strategy for recovery. Methods and Results Focal was induced by photothrombosis. LV‐HDAC2‐shRNA‐GFP, LV‐GFP, Ad‐HDAC2‐Flag, or...
Background One dose of benzathine penicillin G (BPG) has been recommended for HIV-infected patients with early syphilis (primary, secondary, and latent syphilis) in the sexually transmitted diseases treatment guidelines, but clinical data to support such a recommendation are limited. Methods We prospectively observed serological response 1 or 3 weekly doses BPG adults who sought at 8 hospitals around Taiwan. Rapid plasma reagin (RPR) titers were followed every 3–6 months after treatment. The...
Abstract Mechanisms underlying functional recovery after stroke are little known, and effective drug intervention during the delayed stage is desirable. One potential target, protein–protein interaction between neuronal nitric oxide synthase (nNOS) postsynaptic density protein 95 (PSD‐95), critical to acute ischaemic damage neurogenesis. We show that nNOS–PSD‐95 dissociation induced by microinjection of a recombinant fusion protein, Tat‐nNOS‐N 1–133 , or systemic administration...
Stroke is a leading cause of adult disability worldwide, and better drugs are needed to promote functional recovery after stroke. Growing evidence suggests the critical role network excitability during repair phase for stroke recovery. Here, we show that β-hydroxybutyrate (β-HB), an essential ketone body (KB) component, positively correlated with improved outcomes in patients promotes rodents phase. These beneficial effects β-HB depend on HDAC2/HDAC3-GABA transporter 1 (GAT-1)...
Introduction Staphylococcus aureus , is a pathogen commonly encountered in both community and hospital settings. Patients receiving hemodialysis treatment face an elevated risk of vascular access infections (VAIs) particularly infection. This heightened attributed to the characteristics enabling it adhere suitable surfaces form biofilms, thereby rendering resistant external interventions complicating efforts. Methods Therefore this study utilized PCR microtiter dish biofilm formation assay...
The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit telomerase, gene knockout (Tert-/-) causes extremely poor ability in spatial formation. Knockdown TERT dentate gyrus adult hippocampus impairs processes, while overexpression facilitates it. We find plays critical role neural development including dendritic and neuritogenesis hippocampal newborn neurons. A monosynaptic pseudotyped rabies virus retrograde tracing method shows is...
Abstract Fear extinction depends on N-methyl-D-aspartate glutamate receptors (NMDARs) and brain-derived neurotrophic factor (BDNF) activation in the limbic system. However, postsynaptic density-95 (PSD-95) neuronal nitric oxide synthase (nNOS) coupling, downstream signaling of NMDARs activation, obstructs BDNF transduction. Thus, we wondered distinct roles NMDAR PSD-95-nNOS coupling fear extinction. To explore mechanisms, detected protein-protein interaction using coimmunoprecipitation...
Posttraumatic stress disorder subjects usually show impaired recall of extinction memory, leading to extinguished fear relapses. However, little is known about the neural mechanisms underlying memory. We here that activity dorsal hippocampus (dHPC) infralimbic (IL) cortex circuit essential for memory in male mice. There were functional projections from dHPC IL. Using optogenetic manipulations, we observed silencing dHPC-IL inhibited while stimulating facilitated "Impairment consolidation...
Background Poststroke depression and anxiety, independent predictor of poor functional outcomes, are common in the acute phase stroke. Up to now, there is no fast-onset antidepressive anxiolytic agents suitable for management ZL006-05, a dual-target analgesic we developed, dissociates nitric oxide synthase from postsynaptic density-95 while potentiates α2-containing γ-aminobutyric acid type A receptor. This study aims determine whether ZL006-05 can be used as an antistroke agent with...
Background and Purpose- Stroke is a major public health concern worldwide. Although clinical treatments have improved in the acute period after stroke, long-term therapeutics remain limited to physical rehabilitation delayed phase. This study aimed determine whether nNOS (neuronal NO synthase)-CAPON (carboxy-terminal postsynaptic density-95/discs large/zona occludens-1 ligand of nNOS) interaction may serve as new therapeutic target phase for stroke recovery. Methods- Photothrombotic...
This study focused on the energy consumption and environmental comfort of traditional Xindian Central Public Retail Market. Established for more than 30 years, market has been a crucial role in daily life local residents. Thus, level are subjects great concern. By using green building information modeling (BIM) simulation, which is an innovative assessment process that combines buildings BIM architecture, engineering, construction (AEC) industries to achieve sustainability, this explored...
Abstract Environmental enrichment (EE) is a generally accepted strategy to promote stroke recovery and its beneficial effect positively correlated with neuroplasticity. However, the mechanisms underlying it remain elusive. Histone deacetylase 2 (HDAC2), negative regulator of neuroplasticity, up‐regulated after stroke. Thus, we hypothesized that HDAC2 may participate in EE‐mediated recovery. In this study, focal was induced by photothrombosis male mice exposing EE or standard housing (SH)...
Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn (SDH) setting injury represents a key mechanism neuropathic pain. However, directly blocking NMDAR or its downstream signaling, interaction between postsynaptic density-95 (PSD-95) and neuronal nitric oxide synthase (nNOS), causes analgesic tolerance, mainly due to GABAergic disinhibition. The aim this study is explore possibility preventing tolerance through co-targeting signaling γ-aminobutyric acid type...