A5035357062- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Fungal Infections and Studies
- Syphilis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Tuberculosis Research and Epidemiology
- Vaccine Coverage and Hesitancy
- Reproductive tract infections research
- Bacillus and Francisella bacterial research
- Antifungal resistance and susceptibility
- Poxvirus research and outbreaks
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- Hepatitis Viruses Studies and Epidemiology
- Dermatological and COVID-19 studies
- SARS-CoV-2 detection and testing
- Nail Diseases and Treatments
- Research on Leishmaniasis Studies
- Blood groups and transfusion
National Taiwan University
2020-2025
National Taiwan University Hospital
2019-2025
Weatherford College
2021-2022
Gilead Sciences (Australia)
2021
Health Commission of Jilin Province
1992
Background: Stomach cancer is generally thought to evolve through a series of gastric mucosal changes, but the derterminants precancerous lesions are not well understood. purpose : Our was assess risk factors for intestinal metplasia and dysplasia arising from chronicatrophic gastritis in genral population at high stomach cancer. Methods A population-based gastroscopic screening more than 3000 residents conducted county china eith one world's highest rtes Information on lifestyle other...
This was a phase 1, dose-escalation open-label trial to evaluate the safety and immunogenicity of MVC-COV1901, SARS-CoV-2 S-2P protein vaccine adjuvanted with aluminum hydroxide CpG 1018.Between September 28 November 13 2020, 77 participants were screened. Of these, 45 healthy adults from 20 49 years age be administered two doses MVC-COV1901 in 5 μg, 15 or 25 μg spike at days apart. There each dose group; all followed for after second time interim analysis. Adverse events laboratory data...
Background Concurrent sexually transmitted infections (STIs) are common in active populations. We aimed to estimate the prevalence and coinfection rates of bacterial STIs among active, HIV-positive men who have sex with (MSM), assess potential benefits different combination treatment regimens managing concurrent STIs. Methods From September 2021 2023, MSM underwent STI testing when they had symptoms suggestive or recently acquired hepatitis C virus (HCV) infection early syphilis. The oral...
Abstract Background Tenofovir-containing antiretroviral therapy (ART) improves survival in HBV-coinfected people with HIV (PWH). We investigated the incidence of HDV infection and its clinical impact PWH era tenofovir-containing ART. Methods Between 2011 2022, were included followed until December 2023. Anti-HDV antibody screening was performed using sequentially archived blood samples. The timing incident estimated as midpoint between last time point anti-HDV-negative samples first...
While some evidence has suggested the benefits of co-formulated bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) in improving quality life people living with HIV (PLWH), patient-reported outcome studies that focus on Asian population remain scarce. We aimed to determine changes HIV-related symptom burden virally-suppressed PLWH switching B/F/TAF a real-world setting.PLWH stable antiretroviral therapy (ART) for ≥6 months plasma RNA <200 copies/mL who decided switch were eligible...
From June 2022 to April 2023, 1,629 HIV-positive participants were assessed for the risk of atherosclerotic cardiovascular disease (ASCVD). The 10-year ASCVD <5%, 5% <7.5%, ≥7.5% <20% and ≥20% 59.9%, 14.4%, 20.7% 5.0%, respectively; 440 (27.0%) met criteria statin therapy, but only 171 (38.8%) prescribed statins.
The data on immune responses of individuals undergoing MVA-BN vaccination are scarce. We aimed to compare Mpox virus-specific antibody and neutralizing among people with without HIV receiving vaccines. This prospective study enrolled participants two-dose investigate seroresponses after vaccination. Blood samples were collected before each dose for determinations anti-A29 anti-H3 IgG. Neutralization tests conducted tested positive both Overall, 441 enrolled. Seroconversion IgG, respectively,...
Chlamydia trachomatis infection is one of the most common sexually transmitted infections (STIs). This study investigated prevalence and genotype distribution C. trachomatis, treatment response, focusing on recent emergence genovariant L2b in Taiwan. prospective was conducted from August 2021 to September 2023, enrolling 1023 participants, including 492 people who received pre-exposure prophylaxis (PrEP) for HIV 531 with (PWH). Multiple-site sampling genotyping identified were performed....
Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) emtricitabine (FTC) (TDF/FTC) are limited, associations between frequency TDF/FTC administration drug concentration among people on-demand PrEP remain unclear. Fifty-seven participants daily 113 were enrolled this study. The TFV-DP FTC-TP measured dried blood spots using...
The large number of atypical monkeypox (Mpox) cases caused by emerging virus (MPXV) strains was recently found in countries and regions where the Mpox not reported before. Diagnostic tools therapeutic agents are important countermeasures for preventing outbreak. H3L protein is surface antigen MPXV binding to host cell receptors mediating viral infection. A broad range murine anti-MPXV monoclonal antibodies (mAbs) recognizing various epitopes have been generated study. rapid test composed...
COVID-19 vaccination is recommended for at-risk populations, but the vaccine effectiveness in people living with HIV (PLWH) remains incompletely understood. Here we demonstrate that was clinically effective among PLWH during outbreak setting a low endemicity of where non-pharmaceutical interventions were strictly implemented.
Real-world experience with low-level viraemia (LLV) and its impact remain less reported among people living HIV (PLWH) who receive antiretroviral therapy (ART) containing second-generation integrase strand transferase inhibitors, including dolutegravir bictegravir. This retrospective cohort study included virally suppressed PLWH achieved plasma HIV-RNA viral load (PVL) <50 copies/mL for ≥6 months were switched to either dolutegravir- or bictegravir-based ART. Incidence rates of developing...
Understanding the risk behaviors associated with sexually-transmitted hepatitis C virus (HCV) infection among men who have sex (MSM) may inform public health policies and interventions aiming to achieve HCV microelimination.HIV-positive MSM had one of following conditions were enrolled undergo face-to-face questionnaire interviews collect information on their sexual practices in past 12 months: (1) elevation aminotransferases 6 months; (2) acquisition sexually transmitted infections (3)...
Journal Article Suboptimal response to combination therapy with tixagevimab/cilgavimab and remdesivir for persistent SARS-CoV-2 infections in immunocompromised patients Get access Tzong-Yow Wu, Wu Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Search other works by this author on: Oxford Academic PubMed Google Scholar Pao-Yu Chen, Chen TaiwanGraduate Institute Clinical College Taipei, Jann-Tay Wang, Wang TaiwanNational Institutes...
Abstract The unexpected monkeypox (Mpox) outbreak has been reported in many non-endemic countries and regions since May 2022. mutant strains of Mpox virus (MPXV) were found with higher infectivity greater capability for sustained human-to-human transmission, posing a significant public health threat. MPXV A29L, protein homolog vaccinia (VACV) A27L, plays an important role viral attachment to host cell membranes. Therefore, A29L is considered the diagnostic target potential vaccine candidate...
How the hepatitis C virus (HCV) core antigen (HCVcAg) assay performs in detecting recently acquired HCV infection among people living with HIV (PLWH) and HIV-negative men who have sex (MSM) is rarely assessed Asia-Pacific region. High-risk participants, including PLWH sexually transmitted infections (STIs), clearance by antivirals or spontaneously, elevated aminotransferases, MSM STIs on preexposure prophylaxis, low-risk were enrolled. Blood samples subjected to 3-stage pooled-plasma RNA...
COVID-19 rebound is usually reported among patients experiencing concurrent symptomatic and viral rebound. But longitudinal RT-PCR results from early stage to of was less characterized. Further, identifying the factors associated with after nirmatrelvir-ritonavir (NMV/r) molnupiravir may expand understanding rebound.We retrospectively analyzed clinical data sequential receiving oral antivirals between April May, 2022. Viral defined by degree load increase (ΔCt ≥ 5 units).A total 58 27 taking...
Single-dose benzathine penicillin G (BPG) is the preferred therapy for early syphilis, but poorer serologic responses have been observed among people with HIV (PWH). No enhanced regimen has previously shown to improve outcomes of syphilis.We conducted a retrospective study compare treatment single-dose BPG combined 7-day doxycycline versus alone in PWH who presented syphilis. Rapid plasma reagin (RPR) titers were determined every 3-6 months all included PWH. Serologic response was defined as...
Doripenem shows good in vitro activity against common nosocomial pathogens, such as extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. However, the use of doripenem for hospital-acquired pneumonia (HAP) ventilator-associated (VAP) remains controversial. The aim this study was to compare efficacy safety between meropenem patients with HAP or VAP.Adult diagnosed VAP at National Taiwan University Hospital, who received more...
Influenza remains a crucial transmissible disease from community. We aim to identify risk factors associated with mortality among hospitalized patients severe influenza.We retrospectively reviewed medical records of adult laboratory-confirmed influenza at center between January 2016 and December 2018. The primary outcome was 30-day all-cause mortality.Totally 96 were enrolled, 73 in the A group 23 B group. Eighteen (18.8%) deaths occurred within 30 days hospitalization, including 8 (11%) 10...
To investigate the characteristics of dysosmia and dysgeusia among patients diagnosed with coronavirus disease 2019 (COVID-19) in Taiwan. Prospective data collection between January 22, 2020 to May 7, nucleic acid confirmed COVID-19 hospitalized northern Taiwan by Centers for Disease Control were analyzed. Of 217 enrolled, 78 (35.9%) reported (n = 73, 33.6%) and/or 62, 28.6%). The median duration associated symptom-onset development was <1 days (interquartile range [IQR], <1–6 days) 53...
Sepsis remains a common but fatal complication among patients with immune suppression. We aimed to investigate the performance of metagenomic next-generation sequencing (mNGS) compared standard microbiological diagnostics in hematologic malignancies.We performed prospective study from June 2019 December 2019. Adult malignancies and clinical diagnosis sepsis were enrolled. Conventional diagnostic methods included blood cultures, serum galactomannan for Aspergillus, cryptococcal antigen...