A5084302435- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Antimicrobial Resistance in Staphylococcus
- Mosquito-borne diseases and control
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- Vibrio bacteria research studies
- Fungal Infections and Studies
- Urinary Tract Infections Management
- Hepatitis C virus research
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Infectious Diseases and Mycology
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2016-2025
Yale University
2024
Kaohsiung Municipal Ta-Tung Hospital
2010-2024
National Tsing Hua University
2024
Guangzhou University
2024
Texas A&M University
2024
National Taiwan University
2024
National Yang Ming Chiao Tung University
2010-2023
National Academy of Medicine
2019
BackgroundThe Delta and Omicron variants of SARS-CoV-2 are currently responsible for breakthrough infections due to waning immunity. We report phase I/II trial results UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein rationally designed promiscuous peptides representing sarbecovirus conserved helper T cell cytotoxic lymphocyte epitopes on the nucleocapsid (N), membrane (M), spike (S2) proteins.MethodWe conducted I primary 2-dose (28 days apart) 10, 30, or 100 μg UB-612 in 60...
Objectives The global spread and increasing incidence of carbapenem non-susceptible Klebsiella pneumoniae (CnSKP) has made its treatment difficult, the mortality. To establish nationwide data on CnSKP carbapenem-resistance mechanisms, we conducted a national surveillance study in Taiwanese hospitals. Methods We collected 100 247 isolates 2010 2012, respectively. tests performed included antibiotic susceptibility tests; detection carbapenemase, extended-spectrum β-lactamases (ESBL), AmpC...
In 2013 a new reassortant avian influenza A H7N9 virus emerged in China, causing human infection with high mortality. An accurate and timely diagnosis is crucial for controlling the outbreaks of disease. We therefore propose simple strategy rapidly sensitively detecting using an intensity-modulated surface plasmon resonance (IM-SPR) biosensor integrated generated monoclonal antibody. The novel antibody exhibits significant specificity to recognize compared other clinical isolates (p < 0.01)....
ABSTRACT A total of 1,838 subjects from the community and 393 health care-related facilities in Taiwan were evaluated for prevalence nasal Staphylococcus aureus colonization to identify risk factors associated with S. methicillin-resistant (MRSA) colonization. Among subjects, 3.5% had MRSA Subjects a lower rate (19.1%) than (25.2%) but significantly higher (7.63%). Age ( P < 0.001) was significant factor colonization, under age 20 years or between 71 80 showing rates Recent...
We investigated the molecular epidemiology of carbapenem-resistant Acinetobacter baumannii from a Taiwanese hospital and determined mechanisms responsible for resistance.Ninety-two consecutive meropenem-resistant A. isolates collected between January 2005 June 2007 were screened genes encoding OXA carbapenemases, metallo-beta-lactamases carO gene an outer membrane protein. PFGE was used to define clonal relatedness. PCR mapping examine linkage insertion sequences bla(OXA) genes. Southern...
ObjectivesTwo plasmids carrying blaKPC-2 isolated from carbapenem-resistant Escherichia coli (CR-EC) and Klebsiella pneumoniae (CR-KP), respectively, were completely sequenced. The CR-KP strain was selected an outbreak in 2012, the CR-EC first blaKPC-2-carrying E. identified same carbapenem resistance monitoring programme Taiwan.
Abstract Multicenter, longitudinal studies on nontuberculous mycobacteria (NTM) pulmonary infection (PI) are lacking. This study provides a 5-year epidemiological overview of NTM-PI in Taiwan and investigated its predictors. The clinical relevance each respiratory NTM isolate six hospitals between 2008 2014 was determined according to current guidelines. Recurrent episodes were judged by serial bacteriological results. New colonization (PC) occurring since 2010 analyzed. Logistic regression...
Background Among members of Cryptococcus neoformans- gattii species complex, C. neoformans is distributed worldwide whereas considered to be more prevalent in the subtropics and tropics including Taiwan. This nationwide study was undertaken determine distribution genotypes, clinical characteristics outcomes 219 patients with proven cryptococcosis at 20 hospitals representative all geographic areas Taiwan during 1997–2010. Methods Findings Of isolates analyzed, accounted for 210 (95.9%); nine...
Pterostilbene is a methoxylated derivative of resveratrol originated from natural sources. We investigated the antibacterial activity pterostilbene against drug-resistant Staphylococcus aureus and feasibility using it to treat cutaneous bacteria. The antimicrobial effect was evaluated an in vitro culture model vivo mouse infection. minimum inhibitory concentration (MIC) assay demonstrated superior biocidal compared (8~16-fold) methicillin-resistant S. (MRSA) clinically isolated...
Monkeypox has recently been detected outside African countries. This study aimed to report and analyze the first case of monkeypox virus infection in Taiwan.The global epidemiological information was collected from World Health Organization (WHO) US Centers for Disease Control Prevention (CDC). The data confirmed Taiwanese obtained Taiwan Control. diagnosis prevention strategies were WHO guidelines on monkeypox. Phylogenetic tree analysis sequence alignment comparison used identify phylogeny...
Background. Carriage and subsequent infection with methicillin resistant S. aureus (MRSA) its transmission between hospital community settings have not been studied in dialysis patients their contacts. Methods. Surveillance for nasal MRSA carriage among patients, healthcare workers (HCWs) family members a centre was prospectively undertaken during three time periods within 1 year. Molecular typing used to determine epidemiological relationship. Results. Among 1687 samples collected,...
In the 2002 dengue outbreak in Taiwan, some fatal cases had underlying disease of renal failure (RF). Physicians faced difficulty diagnosis and treatment these patients; however, impacts RF on clinical presentations outcomes infection have not been reported previously.A retrospective review was conducted medical records, presentations, laboratory findings, diseases for all a center. Characteristics dengue-infected patients with without were compared.From January through 2003, 519 enrolled,...
The emergence of carbapenem-resistant Acinetobacter baumannii (CRAB) was observed in a Kenyan hospital from 2009 to 2010. Further investigation the dissemination CRAB isolates and molecular characterization associated resistance determinants were therefore performed.Antibiotic susceptibilities determined by broth microdilution Etest. Metallo-β-lactamases detected Etest method. Clonal relationships studied pulsed-field gel electrophoresis (PFGE) multilocus sequence typing (MLST). β-Lactam...
The isolation of OXA-48-producing Enterobacteriaceae has increased dramatically in Mediterranean countries the past 10 years, and recently emerged Asia. Between January 2012 May 2014, a total 760 carbapenem non-susceptible Klebsiella pneumoniae (CnSKP) isolates were collected during Taiwan national surveillance. Carbapenemases detected 210 CnSKP (27.6%), including 162 KPC-2 (n = 1), KPC-3, KPC-17, NDM-1 1 each), OXA-48 4), IMP-8 18), VIM-1 24). four blaOXA-48 late 2013. Herein we report...