A5035394411- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neuroscience of respiration and sleep
- Radiomics and Machine Learning in Medical Imaging
- Medical Image Segmentation Techniques
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Folate and B Vitamins Research
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Face and Expression Recognition
- Infrared Thermography in Medicine
- Computational Drug Discovery Methods
- MRI in cancer diagnosis
- Neuroendocrine regulation and behavior
- Bone health and osteoporosis research
- Cerebrospinal fluid and hydrocephalus
- Medical Imaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- AI in cancer detection
- Neural and Behavioral Psychology Studies
- Digital Imaging for Blood Diseases
- Body Composition Measurement Techniques
- Heart Rate Variability and Autonomic Control
Third Affiliated Hospital of Southern Medical University
2022-2023
Affiliated Hospital of Guizhou Medical University
2022
Guangzhou Medical University
2021
State Key Laboratory of Gas Disaster Detecting, Preventing and Emergency Controlling
2021
Tianjin Municipal Engineering Design and Research Institute
2021
Hospital of Hebei Province
2020
Beijing HuiLongGuan Hospital
2019
Shanghai Jiao Tong University
2018
First Affiliated Hospital Zhejiang University
2018
United Biomedical (United States)
2018
BackgroundThe Delta and Omicron variants of SARS-CoV-2 are currently responsible for breakthrough infections due to waning immunity. We report phase I/II trial results UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein rationally designed promiscuous peptides representing sarbecovirus conserved helper T cell cytotoxic lymphocyte epitopes on the nucleocapsid (N), membrane (M), spike (S2) proteins.MethodWe conducted I primary 2-dose (28 days apart) 10, 30, or 100 μg UB-612 in 60...
Anti-amyloid vaccines may offer a convenient, affordable, and accessible means of preventing treating Alzheimer's disease. UB-311 is an anti-amyloid-β active immunotherapeutic vaccine shown to be well-tolerated have durable antibody response in phase 1 trial. This 2a study assessed the safety, immunogenicity, preliminary efficacy participants with mild disease.A 78-week, randomised, double-blind, placebo-controlled, parallel-group, multicentre, was conducted Taiwan. Participants were...
Abstract Background α‐Synuclein (αSyn) is believed to play a central role in Parkinson's disease (PD) neuropathology and considered target for modification. UB‐312 synthetic αSyn peptide conjugated T helper expected induce antibodies specifically against oligomeric fibrillar αSyn, making potential immunotherapeutic synucleopathies. Objective To investigate the safety, tolerability, immunogenicity of vaccination healthy participants determine safe immunologically optimal dose first‐in‐patient...
Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson's (PD). Here this 44-week, randomized, placebo-controlled, double-blind, single-center phase 1 study investigated safety, tolerability and immunogenicity UB-312, an active immunotherapeutic targeting pathological αSyn, PD. The primary outcome measures were adverse event frequency change anti-αSyn antibody titers blood cerebrospinal fluid (CSF)....
Accumulating studies have shown that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may improve cognitive dysfunction of the patients with schizophrenia (SCZ), but inconsistent results. The present study aims to assess efficacy different frequencies neuronavigated rTMS in ameliorating impairments and alleviating psychotic symptoms. A total 120 were randomly assigned 3 groups: 20 Hz (n = 40), 10 or sham 40) for 8 weeks, then followed up at week 32. Repeatable Battery...
Abstract Cognitive impairment is a central aspect of schizophrenia (SCZ) that occurs at the onset disease and related to poor social function outcome in patients with SCZ. Recent literatures have revealed repetitive transcranial magnetic stimulation (rTMS) be one efficient medical interventions for cognitive impairments. However, no study has been conducted investigate treatment effectiveness 20 Hz rTMS neuronavigation system administered left dorsolateral prefrontal cortex (DLPFC)...
Object The intracranial pulse pressure is often increased when neuropathology present, particularly in cases of (ICP) such as occurs hydrocephalus. This assumed to originate from arterial blood oscillations entering the cranium; fact that there a coupling between and ICP undisputed. In this study, nature how it changes under conditions are investigated. Methods 12 normal dogs, intracarotid parenchymal were measured their was characterized using amplitude phase transfer function analysis....
Abstract Few comparative studies have assessed metabolic brain changes in cognitive impairment among neurodegenerative disorders, and the posterior cingulate cortex (PCC) is a metabolically active region with high involvement multiple processes. Therefore, this study, abnormalities of PCC were compared patients mild (MCI) due to Parkinson’s disease (PD) or Alzheimer’s (AD), as examined by proton magnetic resonance spectroscopy ( 1 H-MRS). Thirty-eight idiopathic PD, including 20 (PDMCI) 18...
The relationship between plasma homocysteine and behavioral psychological symptoms of dementia (BPSD) has not been specifically investigated in previous research. In this study, we compared (Hcy) among 40 Alzheimer’s disease (AD) patients with BPSD, 37 AD without 39 healthy controls. Our results evidenced that the levels BPSD were higher than controls concentration was highest three groups. Significant correlation cognitive decline duration observed, but there no dysfunction or dementia....
Article AbstractObjective: The aim of this study was to explore the integrity association fiber tracts interhemispheric and within-hemispheric communication in patients with remitted geriatric depression (RGD) by diffusion tensor imaging. Method: A region interest-based imaging approach applied tract differences between 37 DSM-IV-diagnosed RGD 33 well-matched, normal, aging healthy controls. Correlations were also sought fractional anisotropy values cognitive performance scores RGD....
Hippocampal volume (HCV) is a key biomarker for both improving subject selection and monitoring treatment efficacy in Alzheimer's Disease (AD) studies. The main goal of the Protocol (http://www.hippocampal-protocol.net/) was to harmonize multiple hippocampal protocols define standard protocol. Additionally, expert hippocampus segmentations 135 ADNI cases will be made available (100 as January 2014).The purpose this work evaluate accuracy BioClinica Multi-Atlas Segmentation (BMAS) algorithm...
The thigh inter-muscular adipose tissue (IMAT) quantification plays a critical role in various medical analysis tasks, e.g., the of physical performance or diagnose knee osteoarthritis. In recent years, several techniques have been proposed to perform automated tissues quantification. However, nobody has provided effective methods track fascia lata, which is an important anatomic trail distinguish between subcutaneous (SAT) and I-MAT thigh. As result, estimation IMAT may not be accurate for...
The tissue quantification in the thigh (e.g. cross-sectional areas of adipose and muscle) is important, since their quantities reflect adverse metabolic effects muscle function. Traditional manual analysis time-consuming operator-dependent, especially case multi-slices or 3D datasets. In clinical trials, there are a large amount datasets acquired from magnetic resonance imaging (MRI) X-ray computed tomography (CT) that requires automatic labeling individual tissues. Since most segmentation...
Vocalizations of male and female African clawed frogs (Xenopus laevis) are generated by brain stem central pattern generators. Serotonin (5-HT) is likely important for vocal initiation because, when applied in vitro, sex-typical fictive vocalizations evoked from isolated brains. To explore the mechanisms underlying initiation, we identified types serotonin receptors mediating activation pharmacologically using a whole brain, preparation. The results showed that 5-HT(2C)-like sexes. 5-HT(2C)...
Brain task-negative networks (default mode network, DMN) and task-positive appear to operate largely in opposition, such that show activation during resting states, whilst are deactivated with the reverse being true goal-oriented behavior. Altered DMN network activity has been observed amnestic mild cognitive impairment (aMCI) subjects. However, no study directly linked patterns of between-state differences same aMCI cohort regarding these two types functional networks. The spatial temporal...
Mild cognitive impairment is an early stage of Alzheimer's disease. Increasing evidence has indicated that training could improve abilities MCI patients in multiple domains, making it a promising therapeutic approach for MCI. However, the effect long-time not been widely explored. It also necessary to evaluate extent how reduce convertion rate from AD. The SIMPLE study multicenter, randomized, single-blind prospective clinical trial assessing effects computerized on different domains...