A5005422348- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Neurological disorders and treatments
- Trace Elements in Health
- Hereditary Neurological Disorders
- Medical Imaging Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Peripheral Neuropathies and Disorders
- ATP Synthase and ATPases Research
- Heme Oxygenase-1 and Carbon Monoxide
- Functional Brain Connectivity Studies
- Neurological diseases and metabolism
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Pesticide Exposure and Toxicity
- Porphyrin Metabolism and Disorders
- Glycogen Storage Diseases and Myoclonus
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Lysosomal Storage Disorders Research
- Infectious Encephalopathies and Encephalitis
Linkou Chang Gung Memorial Hospital
2015-2025
Chang Gung University
2014-2025
Zhujiang Hospital
2025
Chang Gung Memorial Hospital
2013-2024
Memorial Hospital of South Bend
1996-2020
National Institutes for Quantum Science and Technology
2020
Taoyuan Chang Gung Memorial Hospital
2013-2015
May Institute
2010
Taiwan Semiconductor Manufacturing Company (United States)
2010
National Taiwan University Hospital
1989-2005
ABSTRACT One striking clinical feature of hepatitis C virus (HCV) infection is that more than 50% patients with acute will develop chronic infection. To investigate its possible mechanisms, we examined the activation type 2–like T–helper (Th2–like) cells relating to development chronicity. Peripheral blood CD4+ T–cell proliferation and cytokine secretion in response a panel recombinant HCV antigens including core (C22), envelope 1 (E1), E2, nonstructural (NS) protein 4 (C100), fusion NS3 NS4...
One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of pathology are important for health care planning clinical trial design. To estimate the prevalence abnormality persons with normal cognition, subjective cognitive decline, mild impairment, or AD dementia to examine potential implications cutoff methods,...
We report a longitudinal follow-up study on six patients with chronic manganese-induced parkinsonism following cessation of manganese exposure. Compared the 1987 study, their parkinsonian symptoms showed slow progression, particularly in gait disturbances such as freezing during turning and walking backward retropulsion. The mean disability scores King9s College Hospital Rating Scale were 15.0 ± 4.2 28.3 6.7 1991 (<i>p</i> = 0.003, paired <i>t</i> test). Review video records also confirmed...
Several cases of parkinsonism were found in a ferromanganese smelter after the ventilation system had broken down and not been repaired for eight months 1985. To determine aetiology prevalence parkinsonism, 132 workers submitted to thorough medical examination estimated air concentrations carbon monoxide manganese at different worksites. Only six performing electrode fixation or welding during 1985 developed parkinsonism. They exposed 30 minutes each day, seven days week, high (greater than...
Anti-amyloid vaccines may offer a convenient, affordable, and accessible means of preventing treating Alzheimer's disease. UB-311 is an anti-amyloid-β active immunotherapeutic vaccine shown to be well-tolerated have durable antibody response in phase 1 trial. This 2a study assessed the safety, immunogenicity, preliminary efficacy participants with mild disease.A 78-week, randomised, double-blind, placebo-controlled, parallel-group, multicentre, was conducted Taiwan. Participants were...
Abstract We employed 6‐fluorodopa to study the integrity of nigrostriatal dopaminergic projection by positron emission tomography in 4 subjects with clinical features mild parkinsonism caused exposure manganese. The scans were normal. This finding suggests that early manganism sufficient cause parkinsonian deficits, damage may occur pathways postsynaptic system, probably involving striatal or pallidal neurons. Fluorodeoxyglucose showed decreased cortical glucose metabolism, significance...
Background: There is a lack of research exploring the influence role implementation process family caregivers older people with dementia in Taiwan. Purpose: The purpose this study was to investigate predictive ability on positive and negative caregiving outcomes several variables, including mutuality, preparedness, balance between competing needs. Methods: A cross-sectional, correlational design used. Data were collected from patients neurological clinics at medical center local hospitals...
We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over period 5 years after they left the site exposure. Initially appeared to respond open observations, but this apparent benefit was not sustained. This short-term, double-blind indicates that their failed levodopa.
Purpose: The purpose of this study was to explore family caregivers' role-implementation experiences at different stages dementia. Patients and methods: For cross-sectional, exploratory study, 176 dyads caregivers their community-dwelling elderly relatives with dementia were recruited from the neurological clinics a medical center in Taiwan. Family Caregiving Inventory used assess for caregiving activities, role strain, preparation, help others care receivers' Results: activities related...
Abstract Background Aggregation of misfolded amyloid β (Aβ) in senile plaques causes oxidative stress and neuronal death Alzheimer's disease (AD). Compounds possessing antiaggregation antioxidant properties are promising candidate compounds for AD treatment. Methods We examined the potential synthetic derivatives licochalcone A coumarin inhibiting Aβ aggregation, scavenging reactive oxygen species (ROS), providing neuroprotection by using biochemical assays Tet‐On Aβ‐GFP 293/SH‐SY5Y cell...
Abstract Objective This study aims to identify metabolites with altered levels of expression in patients early and progressive stages Alzheimer's disease ( AD ). Methods All participants the underwent genetic screening were diagnosed using both neuropsychological assessment amyloid imaging before metabolome analysis. According these assessments, classified as normal n = 15), mild cognitive impairment 10), 15). Results Using a targeted metabolomic approach, we found that plasma C3, C5, C5‐ DC...
Bilateral hearing impairment is rare in vertebrobasilar occlusive disease. Between 1986 and 1991, we encountered seven patients (four men, three women; median age, 61 years; range, 46-71 years) who had sudden bilateral among 503 with The main initial neurological symptoms were impairment, tinnitus, vertigo. Acute labyrinthitis or Ménière's disease was the diagnosis until subsequent brain stem cerebellar signs appeared. Brain auditory evoked potentials abnormal bilaterally six but unilateral...
<i>Background:</i> The clinical presentations, MRI findings and outcomes for spinal cord infarction (SCI) are well documented in the West but scarce East. We investigated characteristics of SCI patients further analyzed etiologies prognostic factors Chinese subjects. <i>Methods:</i> reviewed all from March 1993 to 2007. Clinical symptoms, laboratory imaging as were retrospectively analyzed. <i>Results:</i> Twenty-two (12 female) identified; their mean age...
Stress, one of the most commonly identified triggers for primary headache in workplace, usually leads to inefficient work during attacks. Stress-related headaches nursing staff hospitals have received little attention.To realize association between stress and headache, means coping with this kind headache.A cross-sectional, hospital-based study using a semi-structured questionnaire was administered 900 staffers tertiary medical center southern Taiwan. Thirty-two items, including basic...
To compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [(18)F]AV-45 positron emission tomography (PET).[(18)F]AV-45 PET was performed in 11 CN, 13 aMCI, 12 AD to cerebral cortex-to-whole cerebellum standard uptake value ratios (SUVRs) of global individual volumes interest (VOIs) cortex. The correlation between cortical SUVRs Mini-Mental State Examination (MMSE) scores analyzed.The were...
Abstract Our study aimed to investigate the incidence, risk factors and time occurrence of malignancy in patients with dermatomyositis (DM) polymyositis (PM). The electronic medical records 1100 DM 1164 PM were studied between January 2001 May 2019. Malignancies after myositis diagnosed 61 (5.55%) 38 (3.26%) PM. cumulative incidence malignancies significantly higher than (hazard ratio = 1.78, log-rank p 0.004). Patients had a greater developing those at 40–59 years old (p 0.01). Most...
Abstract INTRODUCTION We integrated plasma biomarkers from the Taiwan Alzheimer's Disease Neuroimaging Initiative and propose a workflow to identify individuals showing amyloid‐positive positron emission tomography (PET) with low/intermediate tau burden based on [18F]Florzolotau PET‐based quantification. METHODS assessed 361 participants across disease (AD) non‐AD continuum measured phosphorylated (p‐tau)217, p‐tau181, amyloid beta (Aβ)42/40 ratio, neurofilament light chain, glial fibrillary...
Objective: To investigate the relevant factors for rupture of basilar tip aneurysms. Methods: This is a retrospective cohort study. Patients who underwent cerebrovascular digital subtraction angiography at Department Cerebrovascular Disease Surgery,Zhujiang Hospital Southern Medical University from July 2008 to February 2023 and were confirmed have aneurysms retrospectively analyzed. There 45 males 56 females, aged (57.5±10.2) years (range: 36 76 years); maximum diameter aneurysm (M(IQR))...
Objectives – We investigated whether mutation of mitochondrial DNA (mtDNA) affects the copy number genome in patients with myopathy encephalopathy lactic acidosis and stroke-like episodes (MELAS) those myoclonic epilepsy ragged-red fiber (MERRF) syndromes. Materials methods Forty-eight Taiwanese MELAS syndrome 20 MERRF were recruited this study. Results In relation to controls, numbers mtDNA leukocytes or significantly higher at a young age but lower an advanced age. addition, harboring...
<i>Background:</i> Acute intermittent porphyria (AIP) is an inherited disorder of heme biosynthesis, the clinical manifestations which are incompletely understood. In this report, we describe 12 cases AIP, focusing on neurological manifestations. <i>Methods:</i> Twelve patients were diagnosed with AIP basis characteristic findings, erythrocyte porphobilinogen deaminase (PBGD) activity, and molecular genetics. Central peripheral nervous system noted,...