A5072382915- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Nutritional Studies and Diet
- Advanced Neuroimaging Techniques and Applications
- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Neurobiology of Language and Bilingualism
- Obstructive Sleep Apnea Research
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Analytical Chemistry and Chromatography
- Sphingolipid Metabolism and Signaling
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Diet and metabolism studies
- Cognitive Functions and Memory
- Immune cells in cancer
- Memory and Neural Mechanisms
- Sleep and related disorders
- Phytoestrogen effects and research
- Neurological Disease Mechanisms and Treatments
- Mass Spectrometry Techniques and Applications
- Alcoholism and Thiamine Deficiency
- Sleep and Wakefulness Research
Fundacion CITA Alzheimer
2016-2025
Karolinska University Hospital
2018
Karolinska Institutet
2018
Biogipuzkoa Health Research Institute
2018
Research Network (United States)
2018
Goethe University Frankfurt
2018
National University of Distance Education
2018
One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of pathology are important for health care planning clinical trial design. To estimate the prevalence abnormality persons with normal cognition, subjective cognitive decline, mild impairment, or AD dementia to examine potential implications cutoff methods,...
Abstract Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N = 254), mild cognitive impairment 41), AD dementia 31) patients. Participants underwent a lumbar puncture 3 T magnetic resonance imaging. Healthy were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N 220; stage 1, 25; 2/3, 9). assessed the cortical MD, FW,...
Abstract While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate adaptive immune responses affect glioblastoma (GBM) growth treatment resistance. However, impact of major cell population in gliomas, represented by glioma‐associated microglia/macrophages (GAMs), on patients’ clinical course still unclear. Thus, we aimed at assessing immunohistochemical expression selected microglia macrophage markers 344 gliomas...
Abstract Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) methodology Basque population evaluate feasibility adherence FINGER-like multidomain intervention program. Additional aims included assessment of efficacy on cognition data collection design large trial. Method 1-year, randomized, controlled trial persons aged 60+ years, with Cardiovascular Risk Factors, Aging...
Background: Aging is a well-established independent risk factor for both cognitive impairment and sleep disorders, including obstructive apnea (OSA), modifiable yet underrecognized condition. OSA has been implicated in biological mechanisms contributing to Alzheimer’s disease, amyloid-β accumulation, tau phosphorylation, neuroinflammation. This underscores the need optimize diagnosis individuals with an increased of dementia. Methods: cross-sectional observational study enrolled adults aged...
To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score to explore whether this association is related vascular burden CSF biomarkers amyloidosis neurodegeneration.Cognitively normal participants (mean age 57.6 years) from Gipuzkoa Alzheimer Project study were classified as having high (HR; n = 82) or low (LR; 293) for according a CAIDE cutoff 9. Cognitive composites compared between groups. We...
Background:Abnormal cholesterol metabolism changes the neuronal membrane and may promote amyloidogenesis. Oxysterols in cerebrospinal fluid (CSF) are related to Alzheimer’s disease (AD) biomarkers mild cognitive impairment dementia. Cholesterol turnover is important for axonal white matt er (WM) microstructure maintenance. Objective:We aim demonstrate that association of oxysterols, AD biomarkers, WM occurs early asymptomatic individuals. Methods:We studied inter-individual variability CSF...
Brief cognitive tests (BCT) are used in primary care (PC) for the detection of impairment (CI). Still, there little data on their diagnostic utility (DU) a community setting. This work evaluates DU at population level Fototest, [email protected], AD8 questionnaire and MMSE. It provides new cut-off points (CoP) validated CI early program. In validation samples, evaluation was carried out two phases, first screening administration BCT second clinical diagnosis, blinded to results BCT, applying...
<title>Abstract</title> <bold>BACKGROUND: </bold>Accumulating evidence supports the notion that dementia is a multifactorial condition with various risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) demonstrated lifestyle interventions could confer cognitive benefits. Inspired by this, GOIZ-ZAINDU (GZ) feasibility study adapted FINGER approach Basque context. Building upon GZ study, CITA GO-ON trial aims enhance expand...
Abstract Background Sex and gender affect Alzheimer’s Dementia differently. Some studies show that women are diagnosed at a later stage. This represents an essential challenge for healthcare makes research challenging as biases may impact participant selection clinical trials. We examined recruitment the CITA GO‐ON trial, lifestyle intervention trial to prevent cognitive decline. Method The study (ClinicalTrials.gov, NCT04840030) is population‐based randomized aims evaluate effectiveness of...
Los test cognitivos breves (TCB) se utilizan en Atención Primaria (AP) para la detección de deterioro cognitivo (DC) pero existen pocos datos sobre su utilidad diagnóstica (UD) el ámbito comunitario. Este trabajo evalúa UD Fototest, [email protected], cuestionario AD8 y MMSE una muestra representativa población aporta nuevos puntos corte (PdC) que han validado un grupo personas consultan por quejas cognitivas. Ambas muestras, poblacional validación, realizó evaluación 2 fases; primera...
Abstract Background Previous trials in Europe (FINGER, MAPT and PreDIVA) have shown that interventions on risk protective factors represent a window of opportunity for dementia prevention, especially participants with increased risk. To fully understand the potential impact these interventions, their feasibility efficacy needs to be explored contexts worldwide. GOIZ ZAINDU (“caring early” Basque language) is pilot study adapt FINGER methodology Southern aim evaluate lifestyle intervention...
Abstract Background: GOIZ ZAINDU ("caring early" in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) methodology Basque population evaluate feasibility adherence FINGER-like multidomain intervention program. Additional aims included assessment of efficacy on cognition collecting data design large trial. Method: one-year, randomized, controlled trial persons aged 60+ years, with Cardiovascular Risk Factors, Aging...
Abstract Background Aging is consistently associated with cortical gray matter (GM) reductions. Bilingualism has been described as a potential reserve contributor for successful brain aging and variety of structural changes in morphology. In this study we aim to: 1) Explore differences between bilinguals monolinguals on the whole thickness, area volume, 2) explore if correlations age measures are different monolinguals, 3) to evaluate age‐bilingualism interaction effects characteristics....
Abstract Background The FINGER study demonstrated the efficacy of a non‐pharmacological multidomain intervention to prevent cognitive decline in at‐risk older adults. After successful pilot feasibility study, Q3 2021 we launched CITA GO‐ON inspired by methodology demonstrate risk factor and lifestyles multimodal southern Europe. Here describe baseline characteristics participants recruited study. Method (ClinicalTrials.gov, NCT04840030) is two‐year randomized, controlled trial. primary aim...
Abstract Background FINGER trial has demonstrated the potential for dementia prevention by targeting different lifestyle domains in older adults. It highlighted importance of selecting correct window opportunity preventive actions including participants at high risk dementia. This approach is being tested worldwide to support future public health interventions, where selection appropriate target population crucial. Here we share our and results recruiting adults with increased cognitive...
Midlife modifiable dementia risk factors such as cardiovascular health, physical inactivity, depression and low education may count up to a third of cases worldwide. Risk scores based on these midlife could identify at-risk populations for prevention initiatives. FINGER study has shown that multidomain lifestyle intervention beneficial effect cognition. Worldwide initiatives are needed apply this methodology in other sociocultural contexts. Our objectives adapt the context Basque Country...
Abstract Background Abnormal cholesterol metabolism changes the neuronal membrane and interferes with amyloidogenesis. Oxysterols in CSF are related to Alzheimer’s disease (AD) biomarkers mild cognitive impairment dementia. Cholesterol turnover is important for axonal white matter (WM) microstructure maintenance. We aim demonstrate that association of oxysterols, WM occurs early asymptomatic individuals. Method studied inter‐individual variability 24‐hydroxycholesterol (24‐OHC),...
Abstract Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt FINGER methodology the Basque Population and evaluate feasibility adherence FINGER‐like multimodal intervention program. Additional exploratory aims included assessment of efficacy on cognition collection necessary data design large trial. Method one year, randomized, controlled trial persons aged 60+ with increased CAIDE score (≥ 6), no dementia, below‐than‐expected performance at least three cognitive...