A5037442385- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Parkinson's Disease Mechanisms and Treatments
- Bacteriophages and microbial interactions
- Curcumin's Biomedical Applications
- Carbon and Quantum Dots Applications
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Cardiovascular Function and Risk Factors
- Aluminum toxicity and tolerance in plants and animals
- Nanoplatforms for cancer theranostics
- Neurological Disease Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nanoparticle-Based Drug Delivery
- Medicinal Plants and Neuroprotection
- Virus-based gene therapy research
Indian Institute of Chemical Technology
2020-2025
Emory University
2013-2025
Council of Scientific and Industrial Research
2022-2025
Gandhi Medical College & Hospital
2022-2025
Kakatiya University
2020-2024
Government Medical College
2024
Guntur Medical College
2024
Siddhartha Medical College
2024
Niloufer Hospital
2024
Indian Institute of Technology Hyderabad
2020-2023
Abstract The purpose of our study was to determine the toxic effects hippocampal mutant APP and amyloid beta (Aβ) in 12-month-old transgenic mice. Using rotarod Morris water maze tests, immunoblotting immunofluorescence, Golgi-cox staining transmission electron microscopy, we assessed cognitive behavior, protein levels synaptic, autophagy, mitophagy, mitochondrial dynamics, biogenesis, dendritic MAP2 quantified spines number length mice that express Swedish mutation. Mitochondrial function...
The purpose of our study was to understand the toxic effects hippocampal phosphorylated tau in mice. Using rotarod and Morris water maze (MWM) tests, immunoblotting immunofluorescence, Golgi-Cox staining transmission electron microscopy, we assessed cognitive behavior, measured protein levels mitochondrial dynamics, MAP2, total tau, quantified dendritic spines number length 12-month-old mice with P301L mutation. Mitochondrial function by measuring H2O2, lipid peroxidation, cytochrome oxidase...
The purpose of our study was to understand the protective effects reduced expression dynamin-related protein (Drp1) against amyloid beta (Aβ) induced mitochondrial and synaptic toxicities in Alzheimer's disease (AD) progression pathogenesis. Our recent molecular biochemical studies revealed that impaired dynamics—increased fragmentation decreased fusion—in neurons from autopsy brains AD patients transgenic mice expressing Aβ, suggesting Aβ causes AD. Further, co-immunoprecipitation...
One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of pathology are important for health care planning clinical trial design. To estimate the prevalence abnormality persons with normal cognition, subjective cognitive decline, mild impairment, or AD dementia to examine potential implications cutoff methods,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of pandemic disease 2019 (COVID-19) that exhibits an overwhelming contagious capacity over other human coronaviruses (HCoVs). This structural snapshot describes bases underlying SARS-CoV-2 and explains its fast motion epithelia allow rapid cellular entry. Based on notable viral spike (S) protein features, we propose flat sialic acid-binding domain at N-terminal (NTD) S1 subunit leads to more effective first...
Importance Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive amyloid pathology. Objective To examine pathology its dependency on age, sex, education, APOE genotype individuals without dementia. Design, Setting, Participants Cross-sectional analyses were performed using data from Amyloid Biomarker Study...
The purpose of our study was to understand the protective effects a partial reduction dynamin-related protein 1 (Drp1) in Alzheimer’s disease (AD) progression and pathogenesis. Increasing evidence suggests that phosphorylated Tau mitochondrial abnormalities are involved loss synapses, defective axonal transport cognitive decline, patients with AD. In current study, we investigated whether Drp1 protect neurons from Tau-induced synaptic toxicities AD progression. We crossed Drp1+/− mice...
The purpose of our study was to investigate the protective effects a natural product—‘curcumin’— in Alzheimer's disease (AD)-like neurons. Although much research has been done AD, very little reported on curcumin mitochondrial biogenesis, dynamics, function and synaptic activities. Therefore, present investigated against amyloid β (Aβ) induced toxicities. Using human neuroblastoma (SHSY5Y) cells, Aβ, we studied Aβ. Further, also preventive (curcumin+Aβ) intervention (Aβ+curcumin) Aβ SHSY5Y...
The purpose of our study was to better understand the effects mitochondrial-division inhibitor 1 (Mdivi-1) on mitochondrial fission, biogenesis, electron transport activities and cellular protection. In recent years, researchers have found excessive fragmentation reduced fusion in a large number diseases with dysfunction. Therefore, several groups developed division inhibitors. Among these, Mdivi-1 extensively studied reduce dynamin-related protein (Drp1) levels enhance activity protect...
The objective of our study was to better understand the protective effects mitochondria-targeted tetra-peptide SS31 against amyloid beta (Aβ)-induced mitochondrial and synaptic toxicities in Alzheimer's disease (AD) progression. Using intraperitoneal injections, we administered an AD mouse model (APP) over a period 6 weeks, beginning when APP mice were 12 months age. We studied their cortical tissues after treatment determined that crosses blood brain barrier reaches sites free radical...