A5101730785- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Cholesterol and Lipid Metabolism
- Obstructive Sleep Apnea Research
- Amyotrophic Lateral Sclerosis Research
- Cognitive Functions and Memory
- Preterm Birth and Chorioamnionitis
- Electrolyte and hormonal disorders
- Neurobiology of Language and Bilingualism
- Diet and metabolism studies
- Sleep and related disorders
- Healthcare Systems and Public Health
- Maternal and fetal healthcare
- Mass Spectrometry Techniques and Applications
- Pregnancy and Medication Impact
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- COVID-19 Impact on Reproduction
- Maternal Mental Health During Pregnancy and Postpartum
- Endometriosis Research and Treatment
Fundacion CITA Alzheimer
2018-2025
Hospital Universitari i Politècnic La Fe
2020-2025
Amyloidosis Foundation
2023
Biogipuzkoa Health Research Institute
2018
Abstract Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) methodology Basque population evaluate feasibility adherence FINGER-like multidomain intervention program. Additional aims included assessment of efficacy on cognition data collection design large trial. Method 1-year, randomized, controlled trial persons aged 60+ years, with Cardiovascular Risk Factors, Aging...
Importance Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) at higher risk developing dementia. Some individuals SCD+ undergo amyloid-positron emission tomography (PET) as part research studies frequently wish to know their amyloid status; however, disclosure a positive amyloid-PET result might have psychological risks. Objective To assess outcomes in explore which variables...
Background: Aging is a well-established independent risk factor for both cognitive impairment and sleep disorders, including obstructive apnea (OSA), modifiable yet underrecognized condition. OSA has been implicated in biological mechanisms contributing to Alzheimer’s disease, amyloid-β accumulation, tau phosphorylation, neuroinflammation. This underscores the need optimize diagnosis individuals with an increased of dementia. Methods: cross-sectional observational study enrolled adults aged...
Postpartum hemorrhage (PPH) is one of the major causes maternal mortality and morbidity worldwide, with uterine atony being most common origin. Currently there are no obstetrical techniques available for monitoring postpartum dynamics, as tocodynamometry not able to detect weak contractions. In this study, we explored feasibility activity by non-invasive electrohysterography (EHG), which has been proven outperform in detecting contractions during pregnancy. A comparison was made temporal,...
Introduction COVID-19 was declared a pandemic and confinement with movement restriction measures were applied in Spain. Postnatal mental disorders are common but frequently undiagnosed, being risk period to develop anxiety depression symptoms. The aim of this study is evaluate the impact as depressive symptoms pregnant women (PrW) puerperal (PuW) health, well obstetric perinatal outcomes during period.
Background:Abnormal cholesterol metabolism changes the neuronal membrane and may promote amyloidogenesis. Oxysterols in cerebrospinal fluid (CSF) are related to Alzheimer’s disease (AD) biomarkers mild cognitive impairment dementia. Cholesterol turnover is important for axonal white matt er (WM) microstructure maintenance. Objective:We aim demonstrate that association of oxysterols, AD biomarkers, WM occurs early asymptomatic individuals. Methods:We studied inter-individual variability CSF...
Abstract Objective : The assessment of individuals from families affected by familial frontotemporal dementia (FTD) allows the evaluation preclinical or pre-diagnosis disease markers. current work aims to investigate existence a cognitive phase in GRN mutation carriers before overt clinical symptoms begin. Methods: We performed longitudinal neuropsychological analysis (three assessments 4 years) group presymptomatic c.709-1G>A progranulin ( GRN) (n=15) and non-carrier relatives n =25)...
Brief cognitive tests (BCT) are used in primary care (PC) for the detection of impairment (CI). Still, there little data on their diagnostic utility (DU) a community setting. This work evaluates DU at population level Fototest, [email protected], AD8 questionnaire and MMSE. It provides new cut-off points (CoP) validated CI early program. In validation samples, evaluation was carried out two phases, first screening administration BCT second clinical diagnosis, blinded to results BCT, applying...
<title>Abstract</title> <bold>BACKGROUND: </bold>Accumulating evidence supports the notion that dementia is a multifactorial condition with various risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment Disability (FINGER) demonstrated lifestyle interventions could confer cognitive benefits. Inspired by this, GOIZ-ZAINDU (GZ) feasibility study adapted FINGER approach Basque context. Building upon GZ study, CITA GO-ON trial aims enhance expand...
Abstract Background Sex and gender affect Alzheimer’s Dementia differently. Some studies show that women are diagnosed at a later stage. This represents an essential challenge for healthcare makes research challenging as biases may impact participant selection clinical trials. We examined recruitment the CITA GO‐ON trial, lifestyle intervention trial to prevent cognitive decline. Method The study (ClinicalTrials.gov, NCT04840030) is population‐based randomized aims evaluate effectiveness of...
Los test cognitivos breves (TCB) se utilizan en Atención Primaria (AP) para la detección de deterioro cognitivo (DC) pero existen pocos datos sobre su utilidad diagnóstica (UD) el ámbito comunitario. Este trabajo evalúa UD Fototest, [email protected], cuestionario AD8 y MMSE una muestra representativa población aporta nuevos puntos corte (PdC) que han validado un grupo personas consultan por quejas cognitivas. Ambas muestras, poblacional validación, realizó evaluación 2 fases; primera...
Abstract Background Previous trials in Europe (FINGER, MAPT and PreDIVA) have shown that interventions on risk protective factors represent a window of opportunity for dementia prevention, especially participants with increased risk. To fully understand the potential impact these interventions, their feasibility efficacy needs to be explored contexts worldwide. GOIZ ZAINDU (“caring early” Basque language) is pilot study adapt FINGER methodology Southern aim evaluate lifestyle intervention...
Abstract Background: GOIZ ZAINDU ("caring early" in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) methodology Basque population evaluate feasibility adherence FINGER-like multidomain intervention program. Additional aims included assessment of efficacy on cognition collecting data design large trial. Method: one-year, randomized, controlled trial persons aged 60+ years, with Cardiovascular Risk Factors, Aging...
Down-en sindromea (DS) penetrantzia osoa duen genetikoki zehaztutako Alzheimer-en gaixotasunaren (AG) sortzaile da. Memoria ardatz nagusi narriadura kognitiboa da abiapuntu ohikoena. Bizi-itxaropenak 60 urte gainditzearen ondorioz, AGaren garrantzia nabarmen handitu DSarenbarnean. Diagnostiko goiztiarra egitea posible gainerako AG kasuetan bezalaxe, nahiz eta horretarako ezinbestekoa den azterketa neurologiko neuropsikologiko espezializatu bat egin ahal izatea. Narriadura dagoela zehaztu...
Abstract Background Aging is consistently associated with cortical gray matter (GM) reductions. Bilingualism has been described as a potential reserve contributor for successful brain aging and variety of structural changes in morphology. In this study we aim to: 1) Explore differences between bilinguals monolinguals on the whole thickness, area volume, 2) explore if correlations age measures are different monolinguals, 3) to evaluate age‐bilingualism interaction effects characteristics....
Abstract Background The FINGER study demonstrated the efficacy of a non‐pharmacological multidomain intervention to prevent cognitive decline in at‐risk older adults. After successful pilot feasibility study, Q3 2021 we launched CITA GO‐ON inspired by methodology demonstrate risk factor and lifestyles multimodal southern Europe. Here describe baseline characteristics participants recruited study. Method (ClinicalTrials.gov, NCT04840030) is two‐year randomized, controlled trial. primary aim...
Abstract Background FINGER trial has demonstrated the potential for dementia prevention by targeting different lifestyle domains in older adults. It highlighted importance of selecting correct window opportunity preventive actions including participants at high risk dementia. This approach is being tested worldwide to support future public health interventions, where selection appropriate target population crucial. Here we share our and results recruiting adults with increased cognitive...
Midlife modifiable dementia risk factors such as cardiovascular health, physical inactivity, depression and low education may count up to a third of cases worldwide. Risk scores based on these midlife could identify at-risk populations for prevention initiatives. FINGER study has shown that multidomain lifestyle intervention beneficial effect cognition. Worldwide initiatives are needed apply this methodology in other sociocultural contexts. Our objectives adapt the context Basque Country...
Abstract Background Abnormal cholesterol metabolism changes the neuronal membrane and interferes with amyloidogenesis. Oxysterols in CSF are related to Alzheimer’s disease (AD) biomarkers mild cognitive impairment dementia. Cholesterol turnover is important for axonal white matter (WM) microstructure maintenance. We aim demonstrate that association of oxysterols, WM occurs early asymptomatic individuals. Method studied inter‐individual variability 24‐hydroxycholesterol (24‐OHC),...
Abstract Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt FINGER methodology the Basque Population and evaluate feasibility adherence FINGER‐like multimodal intervention program. Additional exploratory aims included assessment of efficacy on cognition collection necessary data design large trial. Method one year, randomized, controlled trial persons aged 60+ with increased CAIDE score (≥ 6), no dementia, below‐than‐expected performance at least three cognitive...