A5103053863- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurological and metabolic disorders
- Radiomics and Machine Learning in Medical Imaging
- Tryptophan and brain disorders
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Axon Guidance and Neuronal Signaling
- Pharmacological Effects and Toxicity Studies
- Neurobiology of Language and Bilingualism
- Schizophrenia research and treatment
- Vaccine Coverage and Hesitancy
- Treatment of Major Depression
- Nicotinic Acetylcholine Receptors Study
University of Freiburg
2013-2025
University Medical Center Freiburg
2014-2024
University of Fribourg
2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2018-2019
GTx (United States)
2019
Roth and Rau (Germany)
2017
German Society of Sport Science
2017
Institute for Frontier Areas of Psychology and Mental Health
2014-2015
Medical University of Vienna
2014
Johannes Gutenberg University Mainz
2012
One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of pathology are important for health care planning clinical trial design. To estimate the prevalence abnormality persons with normal cognition, subjective cognitive decline, mild impairment, or AD dementia to examine potential implications cutoff methods,...
<h3>Objective:</h3> Imaging of regional cerebral glucose metabolism with PET and striatal dopamine D2/D3 receptors (D2R) SPECT improves the differential diagnosis parkinsonism. We prospectively investigated 1) diagnostic merits these approaches in differentiating between Lewy body diseases (LBD; majority Parkinson disease [PD]) atypical parkinsonian syndromes (APS); 2) value [<sup>18</sup>F]fluorodeoxyglucose (FDG)-PET to differentiate among APS subgroups. <h3>Methods:</h3> Ninety-five 107...
Reelin, its lipoprotein receptors [very low density receptor (Vldlr) and apolipoprotein E 2 (ApoER2; also known as Lrp8)], the cytoplasmic adaptor protein disabled 1 (Dab1) are important for correct formation of layers in cerebral cortex. Reeler mice lacking reelin show altered radial neuronal migration resulting an inversion cortical layers. ApoER2 Vldlr double-knockout mutants Dab1 a reeler-like phenotype, whereas milder phenotypes found if only one two is absent. However, precise role...
Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid and cognitive manifestation persons without dementia important for a better understanding of course AD design prevention trials.To investigate whether associated with functioning dementia.This cross-sectional study included 2908 participants normal cognition 4133 mild impairment (MCI) from 53 studies multicenter Amyloid Biomarker Study. Normal was defined as having no...
One long standing aspect of microglia biology was never questioned; their involvement in brain disease. Based on morphological changes (retracted processes and amoeboid shape) that inevitably occur these cells case damage the central nervous system, diseased were called "activated." Because "activated" always found direct neighborhood to dead or dying neuron, since it is known now for more than 20 years cultured release numerous factors are able kill neurons, "activation" often seen as a...
Corticobasal degeneration is an uncommon parkinsonian variant condition that diagnosed mainly on clinical examination.To facilitate the differential diagnosis of this disorder, we used metabolic brain imaging to characterize a specific network can be discriminate corticobasal from other atypical syndromes.Ten non-demented patients (eight females/two males; age 73.9 AE 5.7 years) underwent with 18 F-fluorodeoxyglucose positron emission tomography for parkinsonism.These individuals were...
PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the early diagnosis dementia follow-up patients dementia. We investigated validity relative CBF estimates (R(1)) gained from pharmacokinetic analyses (11)C-labeled Pittsburgh compound B ((11)C-PIB) as a marker neurodegeneration.Twenty-two cognitive impairment (16 Alzheimer disease) underwent (18)F-FDG (11)C-PIB...
Clinical Alzheimer's disease affects both cerebral hemispheres to a similar degree in clinically typical cases. However, atypical variants like logopenic progressive aphasia, neurodegeneration often presents asymmetrically. Yet, no vivo imaging study has investigated whether lateralized corresponds amyloid-β burden. Therefore, using combined (11)C-Pittsburgh compound B and (18)F-fluorodeoxyglucose positron emission tomography, we explored asymmetric deposition is associated with...
Abstract The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with vivo -like microglial-neuronal environment was used to investigate potential contribution Aβ plaque formation. We found that ingested Aβ, thereby preventing formation OHSCs. Conversely, deposits formed rapidly microglia-free wild-type slices. capacity prevent absent forebrain from young adult but not juvenile 5xFamilial Alzheimer’s...
The extracellular matrix molecule Reelin is known to control neuronal migration during development. Recent evidence suggests that it also plays a role in the maturation of postsynaptic dendrites and spines as well synaptic plasticity. Here, we aimed address question whether presynaptic structural organization function. Quantitative electron microscopic analysis number boutons stratum radiatum hippocampal region CA1 did not reveal differences between wild-type animals Reelin-deficient reeler...
Importance Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive amyloid pathology. Objective To examine pathology its dependency on age, sex, education, APOE genotype individuals without dementia. Design, Setting, Participants Cross-sectional analyses were performed using data from Amyloid Biomarker Study...
Abstract Cognitive impairment is a major contributor to the burden in Parkinson’s disease and dementia with Lewy bodies, both of which make up body spectrum, affecting 80% patients over course disease. Macroatrophy microstructural neurodegenerative alterations are typically assessed separately MRI, although neuropathologically they represent same mechanism - loss functional tissue. To gain deeper insight into differential impact neurodegeneration basal forebrain hippocampus on cognition, we...
ABSTRACT BACKGROUND Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome with visuospatial deficits. PET studies have identified hypometabolism of the occipital cortex in PCA. There is, however, huge overlap clinical presentation and involvement between PCA, dementia Lewy bodies (DLB), Alzheimer's disease (AD). Syndrome‐specific patterns metabolism not yet been demonstrated that allow for reliable differentiation [F‐18]‐FDG‐PET. METHODS A total 33 patients (PCA n = 6, DLB...
Early prognostic stratification is desirable in patients with suspected atypical parkinsonian syndromes (APSs) for optimal treatment and counseling. We investigated the value of imaging disease-specific metabolism patterns 18F-FDG PET compared that clinical diagnosis.Seventy-eight APS at study inclusion underwent a follow-up up to 5.9 y after prospective imaging. Survival data were analyzed by Kaplan-Meier Cox regression analyses according diagnostic classifications provided baseline...
Brain imaging with positron emission tomography using [(18) F]fluorodeoxyglucose (FDG-PET) and transcranial B-mode sonography (TCS) improves the differential diagnosis of parkinsonism. The diagnostic merits these approaches in identifying differentiating atypical parkinsonian syndromes (APS) are compared.Data were included from 36 patients clinically suspected APS who underwent PET TCS. FDG-PET scans analyzed by visual assessment (including voxel-based statistical maps) a priori defined...