A5076606508- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Motor Control and Adaptation
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Epilepsy research and treatment
- Neurological and metabolic disorders
- Pharmacological Effects and Toxicity Studies
- Radiopharmaceutical Chemistry and Applications
- Muscle activation and electromyography studies
- Nuclear Receptors and Signaling
- Lanthanide and Transition Metal Complexes
- Action Observation and Synchronization
- Cerebrovascular and Carotid Artery Diseases
- Neurological diseases and metabolism
University Medical Center Groningen
2016-2025
University of Groningen
2014-2023
Paul Scherrer Institute
1995-2015
Hammersmith Hospital
1983-2015
Cyclotron (Netherlands)
1983-2015
University of Zurich
1998-2009
Leiden University Medical Center
2005
Cologne Business School
2005
Radboud University Nijmegen
2002
Tel Aviv Sourasky Medical Center
2001
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses 8 to 9 weeks gestational age, survive the brain and produce marked sustained symptomatic relief a patient severely affected with idiopathic The grafts, which were implanted unilaterally into putamen by stereotactic surgery, restored synthesis storage grafted area, as assessed positron...
Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), utilization (CMRO2) and volume (CBV) were measured in a group of 34 healthy volunteers (age range 22-82 yrs) using the 15O steady-state inhalation method positron emission tomography. Between subjects CBF correlated positively with CMRO2, although interindividual variability values was large. OER not dependent on but highly negatively CBF. CBV When considering all regions interest within single subject, strict coupling...
Abstract Parkinson's disease (PD) is associated with a loss of neurons from the midbrain. The cause PD unknown, but it established that certain neurotoxins can similar syndromes. brain normally protected these noxious blood‐borne chemicals by blood–brain barrier which includes specialized proteins on inside blood vessels in brain. These act as molecular efflux pumps and P‐glycoprotein (P‐gp) an abundant representative. Vulnerability to appears codetermined genotype for P‐gp gene. We...
To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration Parkinson's (PD).We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists (disease duration < = 10 years). We investigated the influence of oestrogen status on: (1) age at onset, (2) presenting symptom, (3) severity progression symptoms (Unified Disease Rating Scale III (UPDRS-III) scores) (4) amount ([123I]FP-CIT single photon emission...
To investigate the pathophysiology of fatigue in MS, we assessed cerebral glucose metabolism (CMR-Glu) 47 MS patients using PET and 18F-fluorodeoxyglucose. Applying Fatigue Severity Scale (FSS), first compared with severe (MS-FAT, n = 19, FSS > 4.9) without (MS-NOF, 16, < 3.7) on a pixel-by-pixel basis Statistical Parametric Mapping (SPM95). Second, values all covering whole range this scale CMRGlu an analysis covariance In addition, determined global by region-of-interest analysis. Sixteen...
The regional distributions of monoamine oxidase (MAO) types A and B have been identified in human brain vivo with intravenously injected 11 C-labeled suicide enzyme inactivators, clorgyline L-deprenyl, positron emission tomography. rapid uptake retention radioactivity for both C tracers indicated irreversible trapping. anatomical distribution paralleled the MAO autopsy material. corpus striatum, thalamus, brainstem contained high activity. magnitudes [ C]clorgyline L-[ C]deprenyl were...
A group of healthy control subjects and patients with Parkinson's disease were investigated using positron emission tomography two tracers as indicators different specific properties the presynaptic dopaminergic system in caudate nucleus putamen. The first tracer, 6-L-(18F)-fluorodopa, was used an analog levodopa to assess its regional brain uptake, conversion into, retention dopamine further metabolites. second (11C)-nomifensine employed indicator striatal monaminergic reuptake sites that...
Ventral mesencephalic tissue from aborted human fetuses (age, 6-7 weeks' postconception) was implanted unilaterally into the putamen using stereotaxic surgery in 2 immunosuppressed patients (Patients 3 and 4 our series) with advanced idiopathic Parkinson's disease. Tissue grafted to each patient. Compared previous patients, following changes grafting procedure were introduced: implantation instrument thinner, more placed operated structure, time between abortion shorter. There no...
L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and patients with Parkinson's disease. Striatal uptake of radioactivity measured using positron emission tomography. The capacity the striatum retain tracer severely impaired compared controls. This may reflect a reduction striatal dopamine storage Patients showing "on/off" phenomenon had an even greater decrease capacity.
The differential diagnosis of neurodegenerative brain diseases on clinical grounds is difficult, especially at an early disease stage. Several studies have found specific regional differences metabolism applying [(18)F]-fluoro-deoxyglucose positron emission tomography (FDG-PET), suggesting that this method can assist in diseases.We studied patients who had FDG-PET scan stage and included those with a retrospectively confirmed according to strictly defined research criteria. Ninety-six could...
We used PET scans with the tracers [18F]fluorodeoxyglucose (FDG) and [11C]raclopride (RACLO) to study glucose metabolism dopamine D2 receptor binding in caudate nucleus putamen of 18 carriers Huntington's disease gene mutation (10 asymptomatic subjects eight untreated symptomatic patients an early stage). also performed MR1 measured bicaudate ratio (BCR) same subjects. Data were compared those from nine mutation-negative members families separate groups age matched controls. The repeated...
WITH the purpose of studying neural activation associated with reward processing in humans, we measured regional cerebral blood flow 10 right-handed healthy subjects performing a delayed go–no go task two different reinforcement conditions. Correct responses were either rewarded by money or simple ‘ok’ reinforcer. Behaviour money, as compared reinforcement, was most significantly dorsolateral and orbital frontal cortex also involved midbrain thalamus. These results may reflect information,...
18F-dopa and S-11C-nomifensine (NMF) are positron emitting tracers whose caudate putamen uptake reflects striatal dopamine storage capacity the integrity of reuptake sites, respectively. Using these two tracers, presynaptic dopaminergic system has been studied with emission tomography (PET) in 10 subjects multiple atrophy (MSA, Shy-Drager syndrome) who had an akinetic-rigid syndrome that was poorly responsive to L-dopa, autonomic failure, cerebellar ataxia. PET findings for MSA patients were...
Decreased blood–brain barrier (BBB) efflux function of the P-glycoprotein (P-gp) transport system could facilitate accumulation toxic compounds in brain, increasing risk neurodegenerative pathology such as Parkinson's disease (PD). This study investigated vivo BBB P-gp patients with parkinsonian syndromes, using [11C]-verapamil PET PD, PSP and MSA patients. Regional differences distribution volume were studied SPM higher uptake interpreted reduced function. Advanced PD had increased frontal...
We used PET with the tracers [18F]fluorodeoxyglucose (FDG), [18F]fluorodopa (FDOPA) and [11C]raclopride (RACLO) to study striatal glucose dopa metabolism, dopamine D2 receptor binding, respectively, in nine patients multiple system atrophy. Ten classical Parkinson's disease were investigated same three tracers' separate groups, each of 10 healthy subjects, served as control populations. found that FDOPA values separated all subjects from parkinsonism but they not useful distinguishing...
Abstract Two patients with Parkinson's disease who underwent implantation of fetal mesencephalic tissue into the putamen were serially studied using positron emission tomography and { 18 F}6‐ L ‐fluorodopa ({ F}dopa). The uptake F}dopa is related to functional integrity presynaptic dopaminergic system. Preoperative studies revealed a marked decrease in uptake, lesser involvement caudate. 4 months, respectively, after operation, both demonstrated improvement, as described elsewhere. One...
Dopamine agonists are used as initial treatment in patients with Parkinson's disease (PD) to reduce incidence and severity of motor complications. This paradigm is based on long-term studies, allowing "rescue" therapy levodopa. The present strict monotherapy study (PELMOPET, the acronym for pergolide-versus-L-dopa-monotherapy-and-positron-emission-tomography trial) evaluated efficacy safety pergolide versus levodopa without medication. multicenter, double-blind, randomized, 3-year trial...
Abstract We used [ 11 C]raclopride (RACLO) and positron emission tomography (PET) to study longitudinally striatal dopamine D 2 receptor binding in nine patients with Parkinson's disease (PD) at an early drug‐naive stage 3–5 years later, when motor fluctuations had appeared seven of them. Patients were treated a combination levodopa agonists. Data compared 10 healthy controls the same age range. Initially, PD showed significant increase RACLO uptake putamen (p < 0.04). The caudate nucleus...
Abstract The primary sensorimotor cortex of the adult brain is capable significant reorganization topographic maps after deafferentation and de‐efferentation. Here we show that patients with spinal cord injury exhibit extensive changes in activation cortical subcortical areas during hand movements, irrespective normal (paraplegic) or impaired (tetraplegic patients) function. Positron emission tomography ([ 15 O]‐H 2 O‐PET) revealed not only an expansion ‘hand area’ towards ‘leg area’, but...