A5015924852- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Spinal Cord Injury Research
- Genetic Neurodegenerative Diseases
- Neuroscience of respiration and sleep
- Botulinum Toxin and Related Neurological Disorders
- Blood Pressure and Hypertension Studies
- Psychosomatic Disorders and Their Treatments
- Obstructive Sleep Apnea Research
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Neural and Behavioral Psychology Studies
- Neuropeptides and Animal Physiology
- Neurosurgical Procedures and Complications
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Cardiac Arrest and Resuscitation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurology and Historical Studies
- Thermoregulation and physiological responses
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Renal and Vascular Pathologies
National Hospital for Neurology and Neurosurgery
2013-2024
University College London
2015-2024
Imperial College London
2010-2024
St Mary's Hospital
2005-2023
St. Mary's Hospital
2005-2023
University of Edinburgh
2023
St Mary's Hospital
2009-2022
Imperial College Healthcare NHS Trust
2015-2022
Hirosaki University
2022
Hospital of St John & St Elizabeth
2015-2021
Human anterior cingulate function has been explained primarily within a cognitive framework. We used functional MRI experiments with simultaneous electrocardiography to examine regional brain activity associated autonomic cardiovascular control during performance of and motor tasks. Using indices heart rate variability, high- low-frequency power in the cardiac rhythm, we observed dorsal cortex (ACC) related sympathetic modulation that was dissociable from motor-related activity. The findings...
Central feedback of peripheral states arousal influences motivational behavior and decision making. The sympathetic skin conductance response (SCR) is one index autonomic arousal. precise functional neuroanatomy underlying generation representation SCR during undetermined, although it impaired by discrete brain lesions to ventromedial prefrontal cortex, anterior cingulate, parietal lobe. We used magnetic resonance imaging study activity associated with spontaneous fluctuations in amplitude...
1. States of peripheral autonomic arousal accompany emotional behaviour, physical exercise and cognitive effort, their central representation may influence decision making the regulation social behaviours. However, cerebral functional neuroanatomy representing mediating responses in humans is poorly understood. 2. Six healthy volunteer subjects underwent H215O positron emission tomography (PET) scanning while performing isometric mental arithmetic stressor tasks, during corresponding control...
Introduction and classification autonomic integration - scientific aspects of structure function failure clinical pathophysiological studies other dysfunction syndromes.
Abstract Using positron emission tomography (PET), we studied regional striatal 18 F‐dopa uptake in 16 patients with L‐dopa‐responsive Parkinson's disease (PD), multiple system atrophy, and 10 progressive supranuclear palsy. Results were compared those of 30 age‐matched normal volunteers. The PD showed significantly reduced mean the caudate putamen to controls, but while function posterior part was severely impaired (45% normal), anterior relatively spared (62% 84% normal). Mean depressed...
BackgroundMultiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that characterised by autonomic failure, cerebellar ataxia, parkinsonism in various combinations. Here we present the final analysis of prospective multicentre study European MSA Study Group to investigate natural history MSA.MethodsPatients with clinical diagnosis were recruited followed up clinically for 2 years. Vital status was ascertained years after completion. Disease...
To evaluate the use of routine MRI in differentiating between patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD) and control subjects.Two neuroradiologists rated blindly independently axial T2-weighted proton density MR images 54 MSA, 35 PSP, 5 CBD, 44 subjects.More than 70% PSP more 80% cerebellar predominant MSA could be classified correctly 0.5-T or 1.5-T scans, no patient these groups was misclassified. In remaining an...
Orthostatic (postural) hypotension (OH) is a common, yet under diagnosed disorder. It may contribute to disability and even death. can be the initial sign, lead incapacitating symptoms in primary secondary autonomic disorders. These range from visual disturbances dizziness loss of consciousness (syncope) after postural change. Evidence based guidelines for diagnostic workup therapeutic management (non-pharmacological pharmacological) are provided on EFNS guidance regulations. The final...
To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH).Patients with nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic neuropathy underwent open-label droxidopa dose optimization (100-600 mg 3 times daily), followed, in responders, by 7-day washout and then a double-blind trial of vs placebo. Outcome measures included patient self-ratings on the Orthostatic Hypotension...
<h3>OBJECTIVES</h3> To determine the sensitivity, specificity, and positive predictive values of a selection abnormal findings in putamen infratentorial structures on routine magnetic resonance imaging for distinguishing between multiple system atrophy, idiopathic Parkinson's disease, age matched controls. <h3>PATIENTS AND METHODS</h3> Two neuroradiologists blindly independently rated axial T2 weighted proton density MRI 44 patients with 47 45 High field (1.5 T) scans were available 16 15...
18F-dopa and S-11C-nomifensine (NMF) are positron emitting tracers whose caudate putamen uptake reflects striatal dopamine storage capacity the integrity of reuptake sites, respectively. Using these two tracers, presynaptic dopaminergic system has been studied with emission tomography (PET) in 10 subjects multiple atrophy (MSA, Shy-Drager syndrome) who had an akinetic-rigid syndrome that was poorly responsive to L-dopa, autonomic failure, cerebellar ataxia. PET findings for MSA patients were...
We present a preliminary report of the discussion joint committee American Spinal Injury Association (ASIA) and International Cord Society concerning development assessment criteria for general autonomic function testing following spinal cord injury (SCI). Elements this were presented at 2005 annual meeting ASIA. To improve evaluation neurological in individuals with SCI therefore better assess effects therapeutic interventions future, we are proposing comprehensive set definitions nervous...
Abstract— We evaluated whether droxidopa, a prodrug converted to norepinephrine, is beneficial in the treatment of symptomatic neurogenic orthostatic hypotension, which results from failure generate an appropriate norepinephrine response postural challenge. Patients with hypotension and Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic neuropathy underwent open-label droxidopa titration (100–600 mg, 3× daily). Responders then received additional 7-day at...