A5064715109- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Restless Legs Syndrome Research
- RNA regulation and disease
- Parkinson's Disease and Spinal Disorders
- Heart Rate Variability and Autonomic Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Sleep and Wakefulness Research
- Ginkgo biloba and Cashew Applications
- Neural dynamics and brain function
- Neurological and metabolic disorders
- stochastic dynamics and bifurcation
- Dementia and Cognitive Impairment Research
- Olfactory and Sensory Function Studies
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
John Wiley & Sons (United States)
2018-2023
Institute of Neurobiology
1994-2023
Ludwig Boltzmann für Klinische Neurobiologie
2020
Hudson Institute
2020
University of Pisa
2020
University College London
1992-2019
Mayo Clinic
2019
University of Bologna
2019
<b>Background: </b> A consensus conference on multiple system atrophy (MSA) in 1998 established criteria for diagnosis that have been accepted widely. Since then, clinical, laboratory, neuropathologic, and imaging studies advanced the field, requiring a fresh evaluation of diagnostic criteria. We held second 2007 present results here. <b>Methods: Experts aspects MSA were invited to participate 2-day conference. Participants divided into five groups, consisting specialists parkinsonian,...
The Movement Disorder Society Task Force for Rating Scales Parkinson's disease (PD) prepared a critique of the Hoehn and Yahr scale (HY). Strengths HY include its wide utilization acceptance. Progressively higher stages correlate with neuroimaging studies dopaminergic loss, high correlations exist between some standardized scales motor impairment, disability, quality life. Weaknesses scale's mixing impairment disability non-linearity. Because is weighted heavily toward postural instability...
Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity limited variant syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- consensus-based revision clinical criteria PSP. Methods: searched PubMed, Cochrane, Medline, PSYCInfo databases articles English...
As there are no biological markers for the antemortem diagnosis of degenerative parkinsonian disorders, currently relies upon presence and progression clinical features confirmation depends on neuropathology. Clinicopathologic studies have shown significant false-positive false-negative rates diagnosing these misdiagnosis is especially common during early stages diseases. It important to establish a set widely accepted diagnostic criteria disorders that may be applied reproduced in blinded...
The clinical features and natural history of 100 patients diagnosed as probable multiple system atrophy (MSA) are described. In all 14 (of 41 deceased) cases who underwent post-mortem examination the brain, diagnosis was confirmed pathologically, providing some validation diagnostic criteria used. There were 67 men 33 women. Median age at onset (at time first reported symptom) 53 (range 33-76) years. Autonomic symptoms initial feature in 41% patients, but had subsequently developed 97%...
Abstract Alpha‐synucleinopathies (ASP) are neurodegenerative disorders, characterized by accumulation of misfolded α‐synuclein, selective neuronal loss, and extensive gliosis. It is accepted that microgliosis astrogliosis contribute to the disease progression in ASP. Toll‐like receptors (TLRs) expressed on cells innate immune system, including glia, TLR4 dysregulation may play a role ASP pathogenesis. In this study we aimed define involvement microglial astroglial activation induced...
We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale-UMSARS). The comprises the following components: Part I, historical, 12 items; II, motor examination, 14 III, autonomic examination; IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior 2 junior raters). applied UMSARS, as well range of other scales, including Unified Parkinson's Disease...
Osteoprotegerin is a novel member of the tumor necrosis factor receptor superfamily and soluble decoy activator nuclear factor-kappaB ligand. Recent experimental research has implicated osteoprotegerin in atherogenesis, but epidemiological confirmation this concept sparse.As part prospective, population-based Bruneck Study, severity, initiation, progression atherosclerosis were assessed carotid arteries. Cases incident cardiovascular disease vascular mortality carefully recorded over 10-year...
BackgroundMultiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that characterised by autonomic failure, cerebellar ataxia, parkinsonism in various combinations. Here we present the final analysis of prospective multicentre study European MSA Study Group to investigate natural history MSA.MethodsPatients with clinical diagnosis were recruited followed up clinically for 2 years. Vital status was ascertained years after completion. Disease...
<h3>Background</h3> Dysarthria and dysphagia are known to occur in parkinsonian syndromes such as Parkinson disease (PD), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP). Differences the evolution of these symptoms have not been studied systematically postmortem-confirmed cases. <h3>Objective</h3> To study differences dysarthria disorders. <h3>Patients Methods</h3> Eighty-three pathologically confirmed...
<b>Objective: </b> To assess the prevalence and severity of restless legs syndrome (RLS) in general community to investigate its potential relationship with iron metabolism other risk factors. <b>Methods: This was a cross-sectional study sex- age-stratified random sample population (50 89 years; n = 701). The diagnosis RLS established by face-to-face interviews; graded on scale. Each subject underwent thorough clinical examination extensive laboratory testing. <b>Results: 10.6% (14.2% women,...
Abstract To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed candidate single nucleotide polymorphism (SNP) association study of 384 most associated SNPs in genome‐wide 413 MSA cases 3,974 control subjects. The 10 significant were then replicated additional 108 537 controls. at SNCA locus significantly with risk for increased development (combined p = 5.5 × 12 ; odds ratio 6.2). Ann Neurol 2009;65:610–614