A5084051379- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Lysosomal Storage Disorders Research
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Metabolism and Genetic Disorders
- Skin and Cellular Biology Research
- Inflammatory Myopathies and Dermatomyositis
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- Dark Matter and Cosmic Phenomena
- RNA regulation and disease
- Nuclear Structure and Function
- Mitochondrial Function and Pathology
- Neurogenetic and Muscular Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Hereditary Neurological Disorders
- Cardiac Arrhythmias and Treatments
- Vestibular and auditory disorders
- Cosmology and Gravitation Theories
- Cellular transport and secretion
Charité - Universitätsmedizin Berlin
2015-2024
Innsbruck Medical University
2015-2024
Universität Innsbruck
2012-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2024
Freie Universität Berlin
2017-2024
Humboldt-Universität zu Berlin
2017-2024
Johannes Gutenberg University Mainz
2011-2023
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2020-2023
University Medical Center of the Johannes Gutenberg University Mainz
2007-2023
John Wiley & Sons (United States)
2023
Background The integrin αvβ3 plays an important role in angiogenesis and tumor cell metastasis, is currently being evaluated as a target for new therapeutic approaches. Several techniques are studied to enable noninvasive determination of expression. We developed [18F]Galacto-RGD, 18F-labeled glycosylated antagonist, allowing monitoring expression with positron emission tomography (PET). Methods Findings Here we show by quantitative analysis images resulting from small-animal PET scanner...
BackgroundMultiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that characterised by autonomic failure, cerebellar ataxia, parkinsonism in various combinations. Here we present the final analysis of prospective multicentre study European MSA Study Group to investigate natural history MSA.MethodsPatients with clinical diagnosis were recruited followed up clinically for 2 years. Vital status was ascertained years after completion. Disease...
Abstract Purpose: The integrin αvβ3 plays a key role in angiogenesis and tumor cell metastasis is therefore an important target for new therapeutic diagnostic strategies. We have developed [18F]Galacto-RGD, highly αvβ3-selective tracer positron emission tomography (PET). Here, we show, man, that the intensity of [18F]Galacto-RGD uptake correlates with expression. Experimental Design: Nineteen patients solid tumors (musculoskeletal system, n = 10; melanoma, 4; head neck cancer, 2;...
Abstract Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due large numbers patients being admitted into hospitals. One potential prognostic indicators in with is frailty. degree frailty could be used assist both triage intensive care, and decisions regarding treatment limitations. Our study sought determine interaction age elderly ICU patients. Methods A prospective multicentre ≥ 70 years care 138 ICUs from 28 countries was conducted....
Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis extracellular matrix remodeling. However, specific roles remain to be validated vivo . Here we show that combined deficiency of cathepsins mice is lethal during the second fourth week life. Cathepsin −/− /L reveal a degree brain atrophy not previously seen mice. This because massive apoptosis select neurons cerebral cortex cerebellar Purkinje granule cell layers. Neurodegeneration...
Abstract Hypomethylation of some portions the genome and hypermethylation others are very frequent in human cancer. The hypomethylation often involves satellite 2 (Sat2) DNA juxtacentromeric (centromere-adjacent) region chromosome 1. In this study, we analyzed methylation centromeric 115 ovarian cancers, 26 non-neoplastic specimens, various normal somatic tissue standards. We found that both types samples increased significantly from toward cancer tissue. Furthermore, strong was more...
Metachromatic leukodystrophy is a lysosomal sphingolipid storage disorder caused by the deficiency of arylsulfatase A. The disease characterized progressive demyelination, causing various neurologic symptoms. Since no naturally occurring animal model available, we have generated A-deficient mice. Deficient animals store cerebroside-3-sulfate in neuronal and nonneuronal tissues. pattern comparable to that affected humans, but gross defects white matter were not observed up age 2 years. A...
Abstract Adjuvant systemic therapy (a strategy that targets potential disseminated tumor cells after complete removal of the tumor) has clearly improved survival patients with cancer. To date, no tool is available to monitor efficacy these therapies, unless distant metastases arise, a situation unavoidably leads death. We analyzed RASSF1A DNA methylation in pretherapeutic sera and serum samples collected 1 year surgery from 148 breast cancer who were receiving adjuvant tamoxifen; 19.6% 22.3%...
Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates desmin. Mutations in the desmin and alpha-B crystallin genes account for approximately one third DRM cases. The genetic basis other forms remain unknown, including early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described five related German patients. Recently, we identified selenoprotein N gene (SEPN1) as responsible...
The aim of the present study was to determine predictive value olfactory dysfunction for early development a synuclein-mediated neurodegenerative disease in subjects with idiopathic REM sleep behavior disorder (iRBD) over an observational period 5 years.Thirty-four patients polysomnography-confirmed iRBD underwent testing using entire Sniffin' Sticks test assessing odor identification, discrimination, and threshold. Patients were prospectively followed up 4.9 ± 0.3 years (mean SD). diagnosis...
Abstract The HER-2/neu gene is amplified and overexpressed in 20% to 30% of invasive breast carcinomas associated with increased metastatic potential less tamoxifen sensitivity. We generated the DNA methylation profiles 143 human tumors found significant differences expression five genes. For three these genes [PGR (coding for progesterone receptor), HSD17B4 type 4 17-β-hydroxysteroid dehydrogenase, an enzyme that mainly degrades active 17-β-estradiol into inactive metabolites), CDH13...