A5025145858- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Transcranial Magnetic Stimulation Studies
- Nerve injury and regeneration
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Medical Imaging Techniques and Applications
- Mitochondrial Function and Pathology
- Restless Legs Syndrome Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Dysphagia Assessment and Management
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Nuclear Receptors and Signaling
- Cognitive and developmental aspects of mathematical skills
- Intracranial Aneurysms: Treatment and Complications
- Trace Elements in Health
- Long-Term Effects of COVID-19
Innsbruck Medical University
2016-2025
Universität Innsbruck
2004-2024
John Wiley & Sons (United States)
2021-2024
Hudson Institute
2021
University Hospital Innsbruck
1999-2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015
Centro de Investigación Biomédica en Red
2015
Biomedical Research Networking Center on Neurodegenerative Diseases
2015
Medical University of Vienna
2012
Imperial College London
2004-2010
Background Although gait disorders are common in the elderly, prevalence and overall burden of these general community is not well defined. Methods In a cross-sectional investigation population-based Bruneck Study cohort, 488 community-residing elderly aged 60–97 years underwent thorough neurological assessment including standardized evaluation. Gait were classified according to an accepted scheme their associations falls, neuropsychological measures, quality life explored. Results Overall,...
To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19.In this prospective, multicenter, observational cohort study we systematically evaluated signs diseases by detailed examination a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assessment), QoL (36-item Short Form), mental health (Hospital Anxiety Depression Scale, Posttraumatic Stress Disorder Checklist-5) disease...
Iron content is increased in the substantia nigra of persons with Parkinson's disease and may contribute to pathophysiology disorder. Early research suggests that iron chelator deferiprone can reduce nigrostriatal disease, but its effects on progression are unclear.
The clinical diagnosis of multiple system atrophy (MSA) is fraught with difficulty and there are no pathognomonic features to discriminate the parkinsonian variant (MSA-P) from Parkinson's disease (PD). Besides poor response levodopa, additional presence pyramidal or cerebellar signs (ataxia) autonomic failure as major diagnostic criteria, certain other known "red flags" warning may raise suspicion MSA. To study role these in MSA-P versus PD patients, a standardized red flag check list...
We applied diffusion-tensor imaging (DTI) including measurements of mean diffusivity (MD), a parameter brain tissue integrity, fractional anisotropy (FA), neuronal fiber as well voxel-based morphometry (VBM), measure gray and white matter volume, to detect changes in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).Magnetic resonance (MRI) was performed 26 iRBD (mean disease duration, 9.2 ± 6.4 years) 14 age-matched healthy control subjects. Statistical...
Although both orthostatic hypotension and urinary incontinence have been reported in a number of parkinsonian syndromes, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), differences the evolution these features not studied systematically pathologically confirmed cases.77 cases syndromes (PD, n=11; MSA, n=15; DLB, n=14; CBD, n=13; PSP, n=24), collected up to 1994, formed...
The aim of the present study was to determine predictive value olfactory dysfunction for early development a synuclein-mediated neurodegenerative disease in subjects with idiopathic REM sleep behavior disorder (iRBD) over an observational period 5 years.Thirty-four patients polysomnography-confirmed iRBD underwent testing using entire Sniffin' Sticks test assessing odor identification, discrimination, and threshold. Patients were prospectively followed up 4.9 ± 0.3 years (mean SD). diagnosis...
Absence of a hyperintense, ovoid area within the dorsolateral border otherwise hypointense pars compacta substantia nigra (referred to as nigral hyperintensity) on iron-sensitive high-field magnetic resonance imaging sequences seems be typical finding for patients with Parkinson's disease (PD).This study was undertaken evaluate diagnostic value hyperintensity in cohort neurodegenerative parkinsonism including PD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) well...
Abstract Background In this study we report on the outcome including overall and cause‐specific mortality of Parkinson's disease (PD) patients subsequent to 38 years surveillance. This is an extension our previous mortality. Methods Two hundred thirty‐seven with a symptom onset between 1974 1984 were followed until date December 31, 2012 or death, representing follow‐up period up years. Overall standardized ratios (SMRs) calculated, predictors for survival at estimated. Results Conclusion...
We assessed loss of dorsolateral nigral hyperintensity (DNH) on high-field susceptibility-weighted imaging (SWI), a novel magnetic resonance marker for Parkinson's disease (PD), in 15 subjects with idiopathic rapid eye movement sleep behavior disorder (iRBD) and compared findings to 42 healthy controls (HCs) 104 PD patients. found DNH at least two thirds iRBD subjects, which approaches the rate observed is contrast HCs. propose that absence SWI could identify prodromal degenerative...
To determine whether automated and observer-independent volumetric MRI analysis is able to discriminate among patients with Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP) in early moderately advanced stages of disease.T1-weighted from clinically probable PD (n = 40), MSA PSP 30) a mean duration 2.8 ± 1.7 y were examined using volume measures 22 subcortical regions. The clinical follow-up period was 2.5 1.2 years. data split into training 72) test...
Parkin disease is usually autosomal recessive; however, two studies have shown that asymptomatic heterozygotes nigrostriatal dysfunction and even manifest subtle extrapyramidal signs. The authors used 18F-dopa PET to study 13 parkin found a significant reduction of (18)F-dopa uptake in caudate, putamen, ventral, dorsal midbrain compared with control subjects. Four had heterozygosity risk factor for some may contribute late-onset Parkinson disease.
Diffusion weighted imaging (DWI) and the trace of diffusion tensor [Trace (D)], a marker water molecule diffusivity, provide information on structural integrity nervous tissues. To investigate lesions within brain's neuronal architecture in early stages Parkinson's disease, 12 patients with disease duration 3.5 +/- 1.5 years were studied DWI. Data compared age-matched healthy control subjects. objectively localize focal changes without having to make an priori hypothesis as its location...
Abstract The disease‐specific Unified Multiple System Atrophy Rating Scale (UMSARS) has been developed recently and validated for assessing disease severity in multiple system atrophy (MSA). Here, we aimed at (1) rates of progression MSA (2) validating UMSARS sensitivity to change over time. Impairment was assessed two time points 12 months apart using Part I (historical review), II (motor examination), as well measures global severity, including IV, Hoehn Yahr (HY) Parkinson's staging,...
To investigate the cerebral dopamine transporter status in early stages of parkinson-variant multiple system atrophy (MSA-P), 15 patients with MSA-P and a disease duration up to 3 years were studied [123I]beta-CIT single photon emission computed tomography (SPECT). Data compared 13 age-matched healthy control subjects idiopathic Parkinson's (IPD), matched for age duration. Parametric SPECT images specific-to-nondisplaceable equilibrium partition coefficient (V3''), which is proportional...
Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little known about patients' own evaluation of their illness factors associated with poor health-related quality (Hr-QoL). We, therefore, assessed Hr-QoL its determinants in MSA. The following scales were applied 115 patients the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression...
The aim of this study was to investigate the distribution and degree asymmetric putaminal dopamine transporter availability in right-handed patients with Parkinson's disease its association severity lateralized motor signs. Asymmetry symptoms defined by difference between right- left-sided scores for items assessed Unified Disease Rating Scale Motor Score a series 68 (disease duration 2.1 ± 1.5 years; 22.7 9). Putaminal measured radioligand [(123)I]β-carboxymethyoxy-3 -β-(4-iodophenyl)...
IntroductionThe hummingbird sign and the morning glory flower sign, reflecting midbrain pathology on MRI, have previously been shown to separate patients with progressive supranuclear palsy (PSP) from those Parkinson's disease (PD) multiple system atrophy (MSA). The aim of present study was determine diagnostic accuracy reproducibility visual assessment patterns in a large cohort neurodegenerative parkinsonism.MethodsRetrospective analysis T1-weighted MRI parkinsonism healthy controls who...