A5082997579- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Multiple Sclerosis Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Pregnancy and preeclampsia studies
- Mitochondrial Function and Pathology
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal and fetal brain pathology
- Ocular Diseases and Behçet’s Syndrome
- Fetal and Pediatric Neurological Disorders
- Renal and related cancers
- Health Systems, Economic Evaluations, Quality of Life
- Genomics and Rare Diseases
- Virology and Viral Diseases
- Myasthenia Gravis and Thymoma
- Pediatric Urology and Nephrology Studies
- Hereditary Neurological Disorders
- Urological Disorders and Treatments
- Neurology and Historical Studies
- Parkinson's Disease and Spinal Disorders
- Biotechnology and Related Fields
- Retinal and Optic Conditions
- Papaya Research and Applications
Aga Khan University Nairobi
2016-2024
Aga Khan University Hospital Nairobi
2016-2024
University College London
1984-2007
National Hospital for Neurology and Neurosurgery
2003-2007
Middlesex University
1989
Middlesex University
1988
University College Hospital
1984-1987
Abstract We present the clinical details and dopamine transporter SPECT scan results of 10 patients with arm tremor, including a rest component reduced swing on affected side, in whom possibility PD had been raised. All signs dystonia or components their tremor that were compatible dystonic none true akinesia fatiguing decrement, even after mean follow‐up period 5.8 years. normal scans. Clinicians should be aware primary adult‐onset can an asymmetric resting impaired sometimes also facial...
Abstract The disease‐specific Unified Multiple System Atrophy Rating Scale (UMSARS) has been developed recently and validated for assessing disease severity in multiple system atrophy (MSA). Here, we aimed at (1) rates of progression MSA (2) validating UMSARS sensitivity to change over time. Impairment was assessed two time points 12 months apart using Part I (historical review), II (motor examination), as well measures global severity, including IV, Hoehn Yahr (HY) Parkinson's staging,...
Abstract Background There is a dearth of knowledge about the availability and affordability different drug treatments for Parkinson's disease (PD) across sub‐Saharan Africa (SSA). We aimed to determine drugs treating PD in Kenya. Methods A facility‐based survey was conducted selected medicine outlets (pharmacies) what were formerly headquarter towns eight provinces used World Health Organization/Health Action International methodology obtain data treat PD. Unit price each obtained. Results...
Abstract Background Africans are underrepresented in Huntington's disease (HD) research. A European ancestor was postulated to have introduced the mutant Huntingtin ( mHtt ) gene continent; however, recent work has shown existence of a unique Htt haplotype South‐Africa specific indigenous Africans. Objective We aimed investigate CAG trinucleotide repeats expansion geographically diverse cohort patients with chorea and unaffected controls from sub‐Saharan Africa. Methods evaluated 99...
Very little is known about the experience of people living with Parkinson's disease (PD) in low- and middle-income countries, such as those sub-Saharan Africa. The number specialists region low awareness limited among population healthcare professionals. Drawing on ten months ethnographic fieldwork urban rural Kenya 55 PD (PwP), 23 family members 22 professionals from public private clinics, we set out to understand diagnosis PwP Kenya. diagnostic journeys our study participants were...
Abstract Background The accessibility of Parkinson's disease medicines is limited across sub‐Saharan Africa, which can have negative health, social and financial consequences for people with their families. However, there a stark gap in the literature regarding impact poor access to on individuals. Objectives study objective was understand Kenya from perspective disease, caregivers neurologists. Methods In‐depth qualitative interviews were conducted 55 23 8 neurologists experience challenges...
Neuromyelitis optica spectrum disorder (NMOSD) is an auto-immune disease of the central nervous system (CNS) associated with IgG-antibody against aquaporin-4 (AQP4-IgG). There little published epidemiology NMOSD from sub-Saharan Africa (SSA). We retrospectively collated cases admitted to our tertiary regional neurology centre. identified 11 (10 female, average age 30 years). 64% (7/11) were seropositive for AQP4-IgG, measured using indirect immunofluorescence. The remaining could either not...
Multiple Sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. There limited literature regarding burden MS sub-Saharan Africa (SSA).To describe demographic and clinical characteristics patients with (PwMS) presenting to a tertiary referral hospital Nairobi.We conducted retrospective descriptive study for PwMS Aga Khan University Hospital, Nairobi from 2008-2018.99 cases met diagnostic criteria male female ratio 1:4. Majority (68.7%) were indigenous...
Abstract A case is described of the prenatal diagnosis choroid plexus cysts at 17 weeks' gestation which persisted beyond 36 weeks but could not be detected after delivery. At birth child was found to have trisomy 18.
Summary. Between August 1982 and July 1986 a total of 163 pregnancies in 136 patients with high genetic risk have had prenatal diagnosis by chorionic villus sampling. Villi were not obtained five (two which subsequently miscarried), 11 fetal losses followed successful sampling (four the fetus was shown to be affected). The rate loss fell increasing experience team. Three sets twins all sampled successfully.
The data that support the findings of this study are available from corresponding author upon reasonable request. Appendix S1. Supplementary tables S2. Education Research Africa Survey Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to article.
Abstract A 30‐year‐old woman had serial ultrasound scans from 28 weeks' gestation which revealed the presence of a cystic area in fetal pelvis. The ‘cyst’ remained unchanged until delivery at 41 weeks. Fetal growth and amniotic fluid volume were normal throughout. pelvic kidney was confirmed birth. differential diagnosis antenatal management this are discussed.
The Galle Medical Journal is published by the Association. journal quarterly in March, June, September and December each year. submissions are accepted throughout aims of to foster co-operation among medical fraternity be a forum make literary contributions, share experiences encountered practice, update their knowledge have debates on topics related all aspects medicine.
Abstract Estimation of maternal serum alpha‐fetoprotein (AFP) was used as a screening method for the detection neural tube defects (NTDs) in 6344 women over three years. Of 88 (1.4 per cent) who had one or more AFP levels equal to, greater than, 2.5 multiples median (MoM) relevant gestational age, 43 (0.68 underwent amniocentesis. There were eight NTDs. Four these screened by AFP, and all cases spina bifida than 3.0 MoM, including small open defect which not seen on ultrasound. The other...
"Hypertension in pregnancy: a trial comparing admission to hospital with management day unit." Journal of Obstetrics and Gynaecology, 7(2), p. 152
Abstract Background Africans are underrepresented in Huntington’s disease research. A European ancestor was postulated to have introduced the mutant Huntingtin ( mHtt ) gene continent, however recent work has shown existence of a unique haplotype South-Africa specific indigenous Africans. Objective We aimed investigate CAG repeats expansion Htt geographically diverse cohort patients with chorea and unaffected controls from sub-Saharan Africa. Methods evaluated 104 participants: 45 chorea, 24...
Abstract INTRODUCTION Paragangliomas (PGs) are rare neuroendocrine tumours that can arise from parasympathetic glossopharyngeal and vagus nerves. Atypical presentations involving seizures dementia occur due to excessive catecholamine release. Physiological intracranial arteriovenous fistulae (AVF) concurrently increased vascularity, especially in the cavernous sigmoid sinuses. METHODS We present a case of patient who developed highly vascular AVF an ipsilateral glomus jugulare PG, presenting...