Francesco Corea
A5088674770- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Multiple Sclerosis Research Studies
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Polyomavirus and related diseases
- Neurosurgical Procedures and Complications
- Cardiac Imaging and Diagnostics
- Telemedicine and Telehealth Implementation
- Peripheral Neuropathies and Disorders
- Rheumatoid Arthritis Research and Therapies
- Peripheral Artery Disease Management
- Acute Lymphoblastic Leukemia research
- Neurology and Historical Studies
- Artificial Intelligence in Healthcare and Education
- Atherosclerosis and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Clinical Reasoning and Diagnostic Skills
- Air Quality and Health Impacts
Azienda Ospedaliero Universitaria San Giovanni Battista
2015-2024
Policlinico Universitario di Catania
2024
University of Catania
2021-2024
University of Campania "Luigi Vanvitelli"
2024
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2023
Istituto Superiore di Sanità
2023
Multiple Sclerosis Foundation
2021-2022
BMI The London Independent Hospital
2022
Ospedale di Spoleto
2021
University of Leicester
2015-2019
Early hemorrhagic transformation (HT) is a complication of ischemic stroke but its effect on patient outcome unclear. The aims this study were to assess: (1) the rate early HT in patients admitted for stroke, (2) correlation between and functional at 3 months, (3) risk factors HT.Consecutive with included prospective 4 centers. was assessed by CT examination performed day 5+/-2 after onset. Study outcomes 3-month mortality or disability. Disability using modified Rankin score (> = indicating...
Background and Purpose— The best time for administering anticoagulation therapy in acute cardioembolic stroke remains unclear. This prospective cohort study of patients with atrial fibrillation, evaluated (1) the risk recurrent ischemic event severe bleeding; (2) factors recurrence (3) risks bleeding associated anticoagulant its starting after stroke. Methods— primary outcome this multicenter was composite stroke, transient attack, symptomatic systemic embolism, cerebral major extracranial...
Abstract Background ChatGPT is an open-source natural language processing software that replies to users’ queries. We conducted a cross-sectional study assess people living with Multiple Sclerosis’ (PwMS) preferences, satisfaction, and empathy toward two alternate responses four frequently-asked questions, one authored by group of neurologists, the other ChatGPT. Methods An online form was sent through digital communication platforms. PwMS were blind author each response asked express their...
<i>Background:</i> Dysphagia is common after stroke. We aimed to study the prognosis of dysphagia (assessed clinically) over first 3 months acute stroke and determine whether specific neurovascular-anatomical sites were associated with swallowing dysfunction. <i>Methods:</i> prospectively examined consecutive patients first-ever The assessment was made using standardized clinical methods. arterial territories involved determined on CT/MRI. All followed up for months....
Background The optimal timing to administer non–vitamin K oral anticoagulants ( NOAC s) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence major bleeding (within 90 days) their who received s for secondary prevention. Methods Results Recurrence was defined as composite stroke, transient attack, symptomatic systemic embolism, cerebral extracranial bleeding. For analysis, 1127 were...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
<i>Background:</i> Hyperglycemia has been claimed to be associated with hemorrhagic transformation (HT) in patients acute ischemic stroke treated thrombolysis. The aim of this study was assess whether the admission blood glucose level is related HT a prospective consecutive stroke. <i>Methods:</i> Consecutive admitted for 4 Italian hospitals were included cohort study. <i>Results:</i> Among 1,125 analysis, 98 (8.7%) had HT: 62 (5.5%) infarction (HI) and 36...
Background and Purpose— The beneficial effect of intravenous thrombolytic therapy in patients with acute ischemic stroke attributable to internal carotid artery (ICA) occlusion remains unclear. aim this study was evaluate the efficacy safety recombinant tissue-type plasminogen activator these patients. Methods— ICARO a case-control multicenter on prospectively collected data. Patients ICA treated within 4.5 hours from symptom onset (cases) were compared matched not (controls). Cases controls...
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
The comparative effectiveness of fingolimod versus interferon beta/glatiramer acetate was assessed in a multicentre, observational, prospectively acquired cohort study including 613 patients with relapsing multiple sclerosis discontinuing natalizumab the Italian iMedWeb registry. First, after suspension, relapse risk during untreated wash-out period and course switch therapies estimated through Poisson regression analyses separated models. During an increased relapses found higher number...
Availability of new disease-modifying therapies (DMTs) and changes therapeutic paradigms have led to a general improvement multiple sclerosis (MS) prognosis in adults. It is still unclear whether this also involves patients with pediatric-onset MS (POMS), whose early management more challenging.To evaluate the POMS over time association managing standards.Retrospective, multicenter, observational study. Data were extracted collected May 2019 from Italian Registry, digital database including...
Stroke has a greater effect on women than men owing to the fact that have more stroke events and are less likely recover. Age-specific rates higher in men; however, because of women's longer life expectancy much incidence at older ages, overall. The aims this prospective study consecutive patients were assess whether there gender differences risk factors, treatment or outcome. Consecutive with ischemic included four centers. Disability was assessed using modified Rankin Scale score (≥3...
Lack of stroke specialists determines that many European rural areas remain underserved. Use telemedicine in care has shown to be safe, increase use evidence-based therapy and enable coverage large low population density. The aim this article is summarise the following recommendations Telestroke Committee Stroke Organisation on setup telestroke networks Europe: Hospitals participating should chosen according criteria include density, transportation distance, geographic specifics in-hospital...
Importance Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years age, it has been suggested that people pediatric-onset MS (POMS) are protected against disability because greater capacity for repair. Objective To assess the incidence and factors associated progression independent relapse activity (PIRA) relapse-associated worsening (RAW) in POMS compared typical adult-onset (AOMS) late-onset (LOMS). Design, Setting, Participants This cohort study on...
<i>Background:</i> The optimal management of patients with cryptogenic ischemic stroke found to have a patent foramen ovale (PFO) at diagnostic workup remains unclear. aims this observational multicenter study were evaluate: (1) the risk recurrent cerebrovascular events in minor or transient attack (TIA) and PFO who either underwent percutaneous closure received only medical treatment, (2) factors associated events. <i>Methods:</i> Consecutive (aged 55 years less)...
This study was designed to derive and validate a score predict early ischemic events major bleedings after an acute stroke in patients with atrial fibrillation.The derivation cohort consisted of 854 fibrillation included prospective series between January 2012 March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) severe enlargement ratio, 2.05; 1.08-2.87) were predictors outcome (stroke, transient attack, systemic embolism) at 90 days from...
Background and Purpose— Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of higher incidence intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed compare (1) the profiles receiving not bridging therapy, (2) overall group outcomes, (3) outcomes according type anticoagulant prescribed. Methods— We analyzed data from prospective RAF RAF-NOACs studies....
<i>Background and Purpose:</i> Generally, the prognosis for cervical artery dissection (CAD) is uncertain. The recanalization rate of CAD can be up to 85% within 3 months. This study evaluates variables that might affect role as a predictor neurological outcome. <i>Patients Results:</i> prospectively included 38 patients with acute stroke following occlusion due (18 males, 20 females, median age 50.5 years, range 16–82). Vertebral carotid dissections were equally...
We studied the correlation between potential causes of stroke (TOAST etiological groups) and involvement different vascular territories seen on computed tomography (CT) scans in patients with ischemic stroke. Information from consecutive a first‐ever have been prospectively coded entered into computerized data bank (Perugia Stroke Registry). A population 1719 were evaluated: 1284 (74.7%) had Large artery disease was main cause entire middle cerebral (MCA) territory infarcts (40.9%),...
An improvement in patient arrival time to stroke unit (SU) is recommended, since earlier management seems improve ‘per se’ functional outcome. The objective of this study was determine if early admission influences the outcome, reduces disability and mortality at discharge three months later independent tlirombolytic treatment. Consecutive acute patients admitted SU between January 1 st 2000 December 31 2003 were studied order analyze actual role specific pharmacological treatment, we...
Particulate air pollution is known to be associated with cardiovascular disease. The relation of particulate cerebrovascular disease (CVD) has not been extensively studied, particularly in different subtypes stroke. A time-series study was conducted evaluate the association between daily and acute stroke unit hospitalizations Mantua, Italy. We analyzed 781 CVD consecutive patients living Mantua county admitted 2006-08. Data on types, demographic variables, risk factors were available from...