A5082604427- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Vestibular and auditory disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Migraine and Headache Studies
- Cerebral Venous Sinus Thrombosis
- Vasculitis and related conditions
- Antiplatelet Therapy and Cardiovascular Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Olfactory and Sensory Function Studies
- Trigeminal Neuralgia and Treatments
- Neuroscience and Neuropharmacology Research
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Hearing Loss and Rehabilitation
- Peripheral Neuropathies and Disorders
- Stroke Rehabilitation and Recovery
Democritus University of Thrace
2008-2019
University Hospital of Alexandroupolis
1988-2019
Sumitomo Dainippon Pharma (United States)
2012-2019
University of Ioannina
2018
National and Kapodistrian University of Athens
2010-2018
University General Hospital Attikon
2011-2018
AHEPA University Hospital
2018
Aristotle University of Thessaloniki
2018
St. Anne's University Hospital Brno
2012
University Hospital Brno
2012
Aim . Caregiver burden (CB) in epilepsy constitutes an understudied area. Here we attempt to identify the magnitude of this burden, factors associated with it, and its impact caregiver quality life (QOL). Methods 48 persons (PWE) underwent video-EEG monitoring their caregivers completed questionnaires providing demographic, disease-related, psychiatric, cognitive, sleep, QOL, information. Results On regression analysis, higher number antiepileptic drugs, poorer patient neuropsychological...
Background and Purpose— The beneficial effect of intravenous thrombolytic therapy in patients with acute ischemic stroke attributable to internal carotid artery (ICA) occlusion remains unclear. aim this study was evaluate the efficacy safety recombinant tissue-type plasminogen activator these patients. Methods— ICARO a case-control multicenter on prospectively collected data. Patients ICA treated within 4.5 hours from symptom onset (cases) were compared matched not (controls). Cases controls...
Glioblastoma cells are resistant to apoptotic stimuli with autophagic death prevailing under cytotoxic stress. Autophagy interfering agents may represent a new strategy test in combination chemo-radiation. We investigated the patterns of expression autophagy related proteins (LC3A, LC3B, p62, Beclin 1, ULK1 and ULK2) series patients treated post-operative radiotherapy. Experiments glioblastoma cell lines (T98 U87) were also performed assess response conditions simulating adverse intratumoral...
<b>Objectives:</b> A simple clinical score (ABCD<sup>2</sup> score) has been introduced to triage TIA patients with a high early risk of stroke. External validation studies have yielded inconsistent results regarding the predictive ability ABCD<sup>2</sup> score. We aimed prospectively validate former in multicenter case series study. <b>Methods:</b> calculated (age [≥60 years: 1 point]; blood pressure [systolic >140 mm Hg or diastolic >90 Hg: 1[; features [unilateral weakness: 2,...
A chronic state of impaired cerebral and cervical venous drainage, termed cerebrospinal insufficiency (CCSVI), has recently been implicated in the pathogenesis multiple sclerosis (MS). We performed a color-coded Doppler sonography case-control study to externally validate CCSVI criteria.We prospectively evaluated consecutive patients with clinically definite MS healthy volunteers using extracranial transcranial sonography. The developed neurosonology criteria for detection were used...
ABSTRACT BACKGROUND There are limited data available regarding symptomatic intracranial atherosclerosis (SIA) prevalence in Caucasians. We sought to investigate SIA among Caucasian patients hospitalized with acute cerebral ischemia (ACI) a prospective, multicenter Transcranial Doppler sonography (TCD) study. METHODS Consecutive ACI were prospectively evaluated TCD over 24‐month‐period. The previously validated criteria of SONIA trial used for detection >50% stenosis TCD. Brain angiography...
Background and Purpose . Cerebral white matter hyperintensities (WMHs) are regarded as typical MRI expressions of small-vessel disease (SVD) common in hypertensive patients. Hypertension induces pathologic changes macrocirculation microcirculation. Changes microcirculation may lead to SVD brain consequently end-organ damage. This damage is the result interactions between macrovascular microvascular levels. We sought investigate association cerebral WMHs with ultrasonographic parameters...
Background and Purpose— Data are scarce on both stroke incidence rates outcomes in Greece rural areas particular. We performed a prospective population-based study evaluating the of first-ever Evros prefecture, region total 147 947 residents located North Eastern Greece. Methods— Adult patients with were registered during 24-month period (2010–2012) followed up for 12 months. To compare our that observed other studies, we standardized rate data according to European Standard Population,...
Three-dimensional (3D) ultrasound imaging is a new technique that maximizes the information and image quality of traditional 2-dimensional (2D) B-mode scanning. The aim this study was to evaluate ability 3D characterize ulcerated atherosclerotic carotid plaque.Using conventional 2D ultrasound, we examined 284 arteries from 142 consecutive patients (101 men 41 women; average age, 64 years). Eighty-two were symptomatic with plaque causing 50-99% stenosis. In 62 arteries, plaques visualized...
<h3>Background and purpose</h3> A recent retrospective study using an online list service established by the American Academy of Neurology has suggested that ischaemic cerebrovascular events may occur in patients who undergo 'bubble studies' (BS) with either transcranial Doppler (TCD) or transoesophageal echocardiography (TOE). The safety TCD-BS for right to left shunt (RLS) identification was evaluated prospectively international multicentre study. <h3>Methods</h3> Consecutive cerebral...
We sought to longitudinally evaluate the potential association of educational level with performance on verbal and nonverbal tasks in individuals mild cognitive impairment (MCI). evaluated patients MCI, age >50 years, no medication intake, absent vascular risk factors, lesions brain magnetic resonance imaging (MRI). Each patient underwent a clinical assessment packet series neuropsychological tests language constructional praxis subtests Cambridge Cognitive Examination (CAMGOG) Boston naming...
Microembolic signals (MES) on transcranial Doppler are an independent risk factor for recurrent stroke in patients with extracranial symptomatic/asymptomatic carotid artery stenosis (CARAS). Clopidogrel load (300 mg) combined dual antiplatelet therapy has been shown to reduce MES symptomatic CARAS. We sought determine feasibility of clopidogrel decreasing asymptomatic embolization CARAS undergoing urgent endarterectomy within the first 2 weeks from index event. Subjects andConsecutive...
The aim was to examine the influence of SCN1A gene polymorphism IVS5-91 rs3812718 G>A on response antiepileptic drugs (AEDs) in monotherapy or polytherapy.Two hundred epilepsy patients and 200 healthy subjects were genotyped for using TaqMan assay. Patients divided into drug-responsive drug-resistant patients. group further studied, comparing maximum minimum doses monotherapy-responsive -resistant groups.There no statistically significant differences allelic frequencies genotype...
Background Epidemiological data on subarachnoid haemorrhage incidence and case-fatality rates are scarce in the southeastern Mediterranean region. We conducted a population-based study Evros Province, located north-eastern Greece, to determine over 5-year period (2001–2005). Methods Province has well-defined, largely homogeneous population with healthcare organised around single tertiary-care University Hospital. prospective computerised registry of permanent residents admitted or...
There are growing concerns for the side effects of dabigatran etexilate (dabigatran), including higher incidence dyspepsia and gastrointestinal bleeding. We conducted a multicenter early implementation study to prospectively evaluate safety, efficacy adherence secondary stroke prevention.Consecutive atrial fibrillation (AF) patients with ischemic (IS) or transient attack (TIA) received prevention during their hospital stay according American Heart Association recommendations at five tertiary...