A5005445227- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
- Parkinson's Disease and Spinal Disorders
- Dementia and Cognitive Impairment Research
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neuropharmacology Research
- Lysosomal Storage Disorders Research
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Advanced Neuroimaging Techniques and Applications
- Ginkgo biloba and Cashew Applications
- Amyotrophic Lateral Sclerosis Research
- Glycogen Storage Diseases and Myoclonus
University of Salerno
2016-2025
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2020-2025
Policlinico Umberto I
2024
Parkinson's UK
2024
University of Catania
2023
John Wiley & Sons (United States)
2023
Hewlett-Packard (Italy)
2017
Istituti Clinici Scientifici Maugeri
2017
Federico II University Hospital
2005-2016
University College London
2011-2016
Abstract We performed a multicenter survey using semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association cognitive impairment, and impact on patients' quality life (QoL). found that 98.6% PD reported presence NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency nocturia (35%), drooling saliva...
Abstract Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either primary or secondary care, and frequently missed during routine consultations. There is no single instrument (questionnaire scale) that enables a comprehensive assessment the range NMS PD both for identification problems measurement outcome. Against this background, multidisciplinary group experts, including patient representatives, has developed an screening questionnaire...
Abstract Non‐motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response treatment NMS. A new 30‐item scale for assessment NMS PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, miscellany. The metric attributes this instrument...
In studies of mild cognitive impairment (MCI) in Parkinson disease (PD), patients without dementia have reported variable prevalences and profiles MCI, likely to be due methodologic differences between the studies.The objective this study was determine frequency profile MCI a large, multicenter cohort well-defined with PD using standardized analytic method common definition MCI.A total 1,346 from 8 different cohorts were included. Standardized analysis verbal memory, visuospatial,...
Depression is a common comorbid condition in Parkinson's disease (PD) and major contributor to poor quality of life disability. However, depression can be difficult assess patients with PD due overlapping symptoms difficulties the assessment cognitively impaired patients. As several rating scales have been used (dPD), Movement Disorder Society commissioned task force their clinimetric properties make clinical recommendations regarding use. A systematic literature review was conducted explore...
Abstract 2006, there was, no single instrument (questionnaire or scale) for attempting a comprehensive assessment of the wide range nonmotor symptoms (NMS) Parkinson's disease (PD). The PD group, multidisciplinary group experts including patient representatives developed and validated NMS screening questionnaire (NMSQuest) comprising 30 items. NMSQuest is self completed tool designed to draw attention presence NMS. In this paper, we present results gathered from 545 patients using definitive...
BackgroundMultiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that characterised by autonomic failure, cerebellar ataxia, parkinsonism in various combinations. Here we present the final analysis of prospective multicentre study European MSA Study Group to investigate natural history MSA.MethodsPatients with clinical diagnosis were recruited followed up clinically for 2 years. Vital status was ascertained years after completion. Disease...
To prospectively assess sensitivity and specificity of magnetic resonance (MR) imaging measurements midbrain, pons, middle cerebellar peduncles (MCPs), superior (SCPs) for differentiating progressive supranuclear palsy (PSP) from Parkinson disease (PD) variant multiple system atrophy (MSA-P), with established consensus criteria as reference standard.All study participants provided informed consent; was approved by the institutional review board. Pons area, midbrain MCP width, SCP width were...
<h3>Importance</h3> We observed a significant correlation between cerebrospinal fluid (CSF) levels of tau proteins and α-synuclein, but not β-amyloid 1-42 (Aβ1-42), lower concentration CSF biomarkers, as compared with healthy controls, in cohort entirely untreated patients Parkinson disease (PD) at the earliest stage studied so far. <h3>Objective</h3> To evaluate baseline characteristics relationship to clinical features biomarkers (Aβ1-42, total [T-tau], phosphorylated threonine 181...
Using resting-state (RS) fMRI, we investigated the functional integrity of default-mode network (DMN) in cognitively unimpaired patients with Parkinson disease (PD).RS fMRI at 3 T was collected 16 PD and age- gender-matched healthy controls. Single-subject group-level independent component analysis used to investigate differences connectivity within DMN Statistical performed using BrainVoyager QX. In addition, voxel-based morphometry test whether between-group RS were related structural...
Abstract Freezing of gait (FOG) is a frequent, disabling symptom Parkinson's disease (PD). FOG usually lasts few seconds. It refers to brief paroxysmal events during which subject unable start or continue locomotion. Despite its frequency, pathophysiology unclear. Because frontal lobe dysfunction disconnection between the and basal ganglia has been implicated in FOG, we explored functions PD patients using neuropsychological tests. Thirteen early‐stage [Hoehn & Yahr score (H&Y) ≤...
Autosomal recessive, early-onset Parkinsonism is clinically and genetically heterogeneous. Here, we report the identification, by homozygosity mapping exome sequencing, of a SYNJ1 homozygous mutation (p.Arg258Gln) segregating with disease in an Italian consanguineous family Parkinsonism, dystonia, cognitive deterioration. Response to levodopa was poor, limited side effects. Neuroimaging revealed brain atrophy, nigrostriatal dopaminergic defects, cerebral hypometabolism. encodes synaptojanin...
Abstract This study was undertaken to determine the prevalence and correlates of cognitive impairment (CI) neuropsychiatric symptoms (NPS) in early, untreated patients with Parkinson's disease (PD). Background Both CI NPS are common PD impact course quality life. However, limited knowledge is available about abilities NPS. Methods Progression Markers Initiative (PPMI) a multi‐site healthy controls (HCs), latter normal cognition. At baseline, participants were assessed neuropsychological...
Importance Deep brain stimulation of the subthalamic nucleus (STN-DBS) improves quality life (QOL) in patients with advanced Parkinson disease (PD). However, controlled studies more than 3 years follow-up are lacking. Objective To investigate long-term effects STN-DBS on QOL compared standard-of-care medication (MED). Design, Setting, and Participants In this prospective, observational, quasi-experimental, longitudinal nonrandomized trial, 183 were screened for eligibility 167 enrolled from...