A5073673044- Aging and Gerontology Research
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Biomedical Ethics and Regulation
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Suicide and Self-Harm Studies
- Ethics in Clinical Research
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Cognitive Functions and Memory
- Migration, Health and Trauma
- Artificial Intelligence in Healthcare and Education
- Lysosomal Storage Disorders Research
- Pharmaceutical Economics and Policy
- Migration, Aging, and Tourism Studies
- Balance, Gait, and Falls Prevention
- Statistical Methods in Clinical Trials
- Migration and Labor Dynamics
- Psychosomatic Disorders and Their Treatments
- Scoliosis diagnosis and treatment
- Nuclear Receptors and Signaling
- HIV-related health complications and treatments
- Autism Spectrum Disorder Research
- Frailty in Older Adults
University of California, Davis
2022-2024
VA Portland Health Care System
2020-2023
Oregon State University
2021
Rutgers, The State University of New Jersey
2020
Evidation Health (United States)
2017-2019
Michael J. Fox Foundation
2014-2015
Pierre Fabre (France)
2006
<h3>Importance</h3> We observed a significant correlation between cerebrospinal fluid (CSF) levels of tau proteins and α-synuclein, but not β-amyloid 1-42 (Aβ1-42), lower concentration CSF biomarkers, as compared with healthy controls, in cohort entirely untreated patients Parkinson disease (PD) at the earliest stage studied so far. <h3>Objective</h3> To evaluate baseline characteristics relationship to clinical features biomarkers (Aβ1-42, total [T-tau], phosphorylated threonine 181...
Fox Trial Finder is an online registry for individuals with and without Parkinson disease (PD) interested in participating PD research. However, distance or disability could prevent such from traditional, clinic-based research at major centers.Use videoconferencing to connect participants specialists to: (1) demonstrate feasibility of virtual visits within this population (2) collect phenotypic data the participants, (3) validate self-reported diagnosis, (4) gauge interest visits.We...
To assess the evolution of triglyceride (TG) levels in HIV-infected patients receiving stable potent antiretroviral therapy treated with N-3 polyunsaturated fatty acids (PUFAs), a prospective double-blind randomized design for reliable assessment TG was performed. One hundred twenty-two >2 g/L and < or =10 after 4-week diet (baseline TG: 4.5 +/- 1.9 g/L) were 8 weeks to PUFAs (2 capsules containing 1 g fish oil 3 times daily, n = 60), placebo (1 paraffin capsules, 62). An 8-week open-label...
Abstract Background Previous studies have demonstrated an association between gait speed and cognitive function. However, the relationship balance cognition remains less well explored. This study examined cross-sectional longitudinal of decline in older adults. Methods A cohort 4,811 adults, aged ≥65 years, participating Cardiovascular Health Study was followed for 6 years. Modified Mini-Mental State Examination (3MSE) Digit Symbol Substitution Test (DSST) were used to measure cognition....
Background: Challenges in clinical trial recruitment threaten the successful development of improved therapies.This is particularly true Parkinson's disease (PD) studies modification where population interest difficult to find and study design more complex.Objective: This paper seeks understand how STEADY PD III, a National Institute Neurological Disorders Stroke (NINDS) funded phase 3 evaluating efficacy isradipine as modifying agent for PD, was able recruit their full target 6 months ahead...
Objectives Adverse childhood experiences (ACEs) are associated with higher risk of chronic disease, but little is known about the association late life cognitive decline. We examined longitudinal between ACEs and late-life decline in Study Healthy Aging African Americans (STAR). Design Linear mixed models random intercepts slope individual composite change adjusting for years from baseline (timescale), age, sex, parental education, socioeconomic status social support. Participants reported...
Background: As in other therapeutic areas, clinical studies Parkinson's disease (PD) face significant recruitment challenges. However, qualitative surveys suggest that individuals with PD are willing to participate research. The Michae
AbstractAbstractVeteran engagement in care is imperative to suicide prevention. However, barriers engaging veterans at risk for remain a challenge, and women may have unique experiences that promote or inhibit care-seeking behaviors. The goal of this study was better understand facilitators among high identify potential gender differences. We interviewed 25 men utilizing VHA health across the United States (U.S.), who had recent attempt (6 months prior). Psychological safety dominant theme...
Timely and efficient clinical trial recruitment is a chronic problem across diseases. The Michael J Fox Foundation for Parkinson‘s Research (MJFF) leading funder sponsor of disease research. Solving challenges in priority the MJFF led to development an online tool – Trial Finder that connects participants trials. As Progression Markers Initiative, observational biomarkers study, developed first-hand expertise planning tactical implementation. poor enrollment relies on all stakeholders...
Understanding the nature of suicidal ideation, or how ideation is experienced by individual in its course and development, important for informing assessment treatment. In this study, we conducted qualitative interviews with a national sample fifty United States (U.S.) military veterans recent suicide attempts to elucidate from perspective those lived experience. We interviewed 25 women men Veterans Health Administration healthcare facilities across U.S. who made (prior 6 months) attempt....
Abstract Background Few studies have investigated the relationship between subjective cognitive concerns and objective decline in oldest‐old or examined gender differences. We evaluated this association stratification by a diverse cohort of adults ages 90+. Methods LifeAfter90 is an ongoing Verbal episodic memory (VEM) executive function (EF) were assessed every 6‐months since 2018 using Spanish English Neuropsychological Assessment Scales. operationalized cognition two ways: 1)...
Abstract Background Gender differences are often associated with specific cognitive domains. Additionally, gender may be BMI through biological and social differences. We evaluated if mid‐life mediated the effect of on domain cognition in an ethnoracially diverse population individuals 80+. Method Data from three ongoing cohort studies, LifeAfter90, Kaiser Healthy Aging Diverse Life Experiences, Study African Americans, was pooled to include participants aged 80+ (n = 671). Baseline verbal...
Abstract Background Widowhood is associated with cognitive impairment, which salient for the oldest‐old, who are at high risk of decline and spousal loss. We assessed association marital status in LifeAfter90 Study (LA90) examined effect modification by gender. Method LA90 enrolled participants aged 90+ were long‐term members Kaiser Permanente Northern California. Analyses included identifying as married, separated, or widowed (excluding single never married individuals due to small...
There is no “department of cures.”[1][1] are many diverse players involved in drug development, each whom brings critical financial, intellectual, and human resources to the process. However, one charge overall direction field takes—charting course
Abstract Background Discrimination is a primary cause of health inequities, and racial/ethnic disparities in dementia are well documented. However, it unclear whether longevity into old age indicates overcoming discriminatory experiences. Using data from the LifeAfter90 (LA90) Study, we examined impact major lifetime discrimination on cognitive function decline those 90+. Method LA90 enrolled Asian, Black, Latino, white, multi‐racial Kaiser Permanente Northern California members who were...
Abstract Background The oldest‐old are the fastest growing segment of elderly population but very little is known about cognition in this age group; particularly diverse populations. Our goal was to evaluate if domain specific cognitive change different across ethnoracial groups those aged 90+. Method LifeAfter90 (LA90) an ongoing cohort participants 90+ who long‐term members Kaiser Permanente Northern California participants. Participants (n = 984) were interviewed every 6 months for up 3.5...
Abstract Previous research has reported an association between balance and cognitive function; however, there is a paucity of data on this relationship over time. This study examined the cross-sectional longitudinal function in 4,811 participants aged 65 years older Cardiovascular Health Study (CHS). Cognitive measures included Modified Mini-Mental State Examination (3MSE) Digit Symbol Substitution Test (DSST); were collected annually for six years, starting 1992-1993. A tandem stance test...
Abstract Background Studies have shown that military veterans are at higher risk of dementia. Less is known about cognitive aging and decline, especially among who survived past age 90. We investigated the association service with function decline in LifeAfter90 (LA90) cohort. Method LA90 included Asian, Black, Latino, White, multi‐racial individuals aged 90 years or more without a history dementia diagnosis recruitment. assessed active US via self‐report baseline. Due to small number women...
Abstract Background Childhood socioeconomic status (SES) is associated with cognitive functioning in adulthood. It not known if this relationship endures the oldest old. We examined associations of subjective and objective childhood SES baseline cognition decline LifeAfter90 (LA90) cohort. Method LA90 an ongoing diverse cohort individuals aged 90+ without dementia diagnoses at recruitment. In our analytic sample (n = 341), we operationalized as maternal education (range 0‐20 years); paternal...
Abstract Background Prior studies have suggested immigration may be associated with different cognitive decline; however, this has not been explored in those aged 90+ years. This study examined the association between United States (US) born vs non‐US and decline a diverse cohort of oldest‐old. Method We followed 641 participants LifeAfter90 study, an ongoing to evaluate aging incident dementia individuals recruited from Kaiser Permanente Northern California. Verbal episodic memory (VEM),...