A5087266700- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Aging and Gerontology Research
- Diabetes Management and Research
- Health, Environment, Cognitive Aging
- Cardiac Health and Mental Health
- Diabetes Treatment and Management
- Migration, Health and Trauma
- Nutritional Studies and Diet
- Frailty in Older Adults
- Diabetes and associated disorders
- Cardiovascular Health and Risk Factors
- Retirement, Disability, and Employment
- Birth, Development, and Health
- Geriatric Care and Nursing Homes
- Migration, Aging, and Tourism Studies
- Diet and metabolism studies
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Posttraumatic Stress Disorder Research
- Sleep and related disorders
- Cognitive Functions and Memory
- Stroke Rehabilitation and Recovery
- Racial and Ethnic Identity Research
- Identity, Memory, and Therapy
Kaiser Permanente
2017-2025
University of California, San Francisco
2016-2024
University of California, Davis
2017-2023
University of Kentucky
2021
Kaiser Permanente Oakland Medical Center
2018-2021
University of California, Irvine
2019
Icahn School of Medicine at Mount Sinai
2018
Sheba Medical Center
2018
San Francisco Department of Public Health
2018
University of Washington
2016-2018
Abstract Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD) differ by world region, suggesting that there are potentially modifiable factors for intervention. However, few epidemiological clinical ADRD studies examine sex differences; even fewer evaluate context risk. The goals this perspective to: (1) provide definitions gender, biologic sex, sexual orientation. limitations examining these as binary variables; (2) an overview what is known with regard...
Abstract INTRODUCTION We evaluated the independent associations between high‐density lipoprotein cholesterol (HDL‐C) and triglyceride (TG) levels with Alzheimer's disease related dementias (ADRD). METHODS Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs HDL‐C conditional age, sex, body mass index. included these residuals individually concurrently in Cox models predicting ADRD incidence. RESULTS Low (hazard ratio [HR]...
<h3>Objective</h3> Women have >50% greater lifetime risk of dementia than men but the role female-specific endocrine milieu is not well-understood. This study evaluates associations between indicators estrogen exposure from women9s reproductive period and in a large diverse population. <h3>Methods</h3> We evaluated 15,754 female members (29.9% nonwhite) Kaiser Permanente with clinical examinations health survey data 1964 to 1973 were as January 1, 1996. In midlife (mean age 51.1 years),...
<h3>Objective:</h3> To evaluate the association of early-adulthood and mid-adulthood hypertension with dementia in men women. <h3>Methods:</h3> We evaluated 5,646 members a diverse integrated health care delivery system who had clinical examinations survey data from 1964 to 1973 (mean age 32.7 years; early adulthood) 1978–1985 44.3 mid-adulthood) were as January 1, 1996 59.8 years). Hypertension categories based on measurements blood pressure (BP) change between 2 (e.g., onset hypertension)...
OBJECTIVE In children with type 1 diabetes (T1D), severe hypoglycemia (SH) is associated poorer cognition, but the association of SH cognitive function in late life unknown. Given increasing expectancy people T1D, understanding role brain health crucial. RESEARCH DESIGN AND METHODS We examined between and 718 older adults T1D from Study Longevity Diabetes (SOLID). Subjects self-reported recent (previous 12 months) lifetime history resulting inpatient/emergency department utilization. Global...
Abstract Introduction Post‐traumatic stress disorder (PTSD) is associated with an increased risk of dementia in male veterans, but little known females and civilians. Methods PTSD comorbidities were abstracted from medical records 1/1/1996 to 12/31/2001. Dementia incidence 1/1/2002 12/31/2014 499,844 health care members aged 60+ years over average 8.2 years. Cox proportional hazard models adjusted for age, demographics, comorbidities. Results was 8 follow‐up (females: ratio [HR] = 1.59, 95%...
Importance Higher educational attainment is associated with reduced dementia risk, but the role of quality understudied, presenting a major evidence gap, especially as it may contribute to racial inequities. Objective To evaluate association between state-level during childhood and risk. Design, Setting, Participants This cohort study analyzed longitudinal data collected from January 1, 1997, through December 31, 2019 (23-year follow-up period). The sample comprised members Kaiser Permanente...
Background Post-traumatic stress disorder (PTSD) has been linked to hypertension, but most research on PTSD and hypertension is cross-sectional, potential mediators have not clearly identified. Moreover, twice as common in women men, understanding of the PTSD-hypertension relationship limited. We examined trauma exposure symptoms relation incident over 22 years 47 514 civilian Nurses’ Health Study II. Method used proportional hazards models estimate hazard ratios (HRs) 95% confidence...
Birth in a group of predominantly southern US states is robustly linked to increased stroke risk. Given the role cerebrovascular disease dementia risk, geographic patterning may also occur for incidence.To determine whether birth 9 high mortality (HSMSs) associated with diverse cohort individuals living Northern California.An observational study included 7423 members Kaiser Permanente California (KPNC), an integrated health care delivery system, survey and clinical examination data...
OBJECTIVE Individuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control ideal for maintaining late-life brain health. We investigated the association long-term dementia older individuals diabetes. RESEARCH DESIGN AND METHODS followed 3,433 members a health care system diabetes, aged ≥50 years, from 1996 to 2015. Repeated measurements hemoglobin A1c (HbA1c), diagnoses, and comorbidities were ascertained records. Cox...
Background: Posttraumatic stress disorder is associated with increased dementia risk but less known about because of everyday problems in diverse populations. Methods: A total 9605 health care plan members who provided information regarding midlife stressors 1972 to 1973 (ages, 40 55 y) were followed for diagnosis between 1996 and 2017. Cox proportional hazard models evaluated associations adjusting demographics lifecourse indicators. Results: Reporting at least 1 stressor was 17% greater...
Childhood socioeconomic status (cSES) is a powerful predictor of adult health, but its operationalization and measurement varies across studies. Using Health Retirement Study data (HRS, which nationally representative community-residing United States adults aged 50+ years), we specified theoretically-motivated cSES measures, evaluated their reliability validity, compared performance to other indices. HRS respondent (N = 31,169, interviewed 1992–2010) were used construct index reflecting...
Importance High education protects against dementia, but returns on educational attainment may be different across sociodemographic groups owing to various social factors. Asian American individuals are a growing and diverse group, little research has assessed dementia determinants in this population. Objective To examine the association of with large cohort individuals, stratifying by ethnicity nativity. Design, Setting, Participants This study used electronic health record (EHR) survey...
Importance The association between hypertension developed before midlife and late-life brain health is understudied and, because of the cardioprotective benefits estrogen menopause, may differ by sex. Objective To assess early adulthood blood pressure (BP) change with neuroimaging biomarkers examine potential sex differences. Design, Setting, Participants This cohort study used data from Study Healthy Aging in African Americans (STAR) Kaiser Diverse Life Experiences (KHANDLE) study, which...
<h3>Background and Objectives:</h3> The associations of high- low-density lipoprotein cholesterol (HDL-C LDL-C) with dementia risk in later life may be complex, few studies have sufficient data to model non-linearities or adequately adjust for statin use. We evaluated the observational HDL-C LDL-C incident a large well-characterized cohort linked survey electronic health record (EHR) data. <h3>Methods:</h3> Kaiser Permanente Northern California plan members aged 55 years older who completed...
Importance The levels of glycemic control associated with the lowest risk dementia in people type 2 diabetes are unknown. This knowledge is critical to inform patient-centered target setting. Objective To examine associations between cumulative exposure various ranges glycated hemoglobin (HbA 1c ) concentrations across sex and racial ethnic groups association current therapeutic targets risk. Design, Setting, Participants cohort study included members Kaiser Permanente Northern California...
The prevalence of poor sleep quality and apnea differs by race ethnicity may contribute to racial disparities in cognitive aging. We investigated whether risk were associated with function decline the associations differed race/ethnicity.
Abstract INTRODUCTION Depressive symptoms are associated with higher risk of dementia, but how they impact cognition in diverse populations is unclear. METHODS Asian, Black, Latino, or White participants ( n = 2227) the Kaiser Healthy Aging and Diverse Life Experiences (age 65+) Study African Americans 50+) underwent up to three waves cognitive assessments over 4 years. Multilevel models stratified by race/ethnicity were used examine whether depressive decline associations differed...
Background Although research has demonstrated that depressive symptoms predict stroke incidence, are dynamic. It is unclear whether risk persists if remit. Methods and Results Health Retirement Study participants (n=16 178, free noninstitutionalized at baseline) were interviewed biennially from 1998 to 2010. Stroke assessed through self‐report of doctors’ diagnoses a modified Center for Epidemiologic Studies ‐ Depression scale (high was ≥3 symptoms), respectively. We examined symptom...