A5016959999- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Lipoproteins and Cardiovascular Health
- Air Quality and Health Impacts
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Diet, Metabolism, and Disease
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Migraine and Headache Studies
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Microscopic Colitis
- Health, Environment, Cognitive Aging
- Gestational Trophoblastic Disease Studies
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Neuroendocrine Tumor Research Advances
- Economic and Financial Impacts of Cancer
- Genomics and Rare Diseases
University of California, San Francisco
2019-2025
Kaiser Permanente
2023-2025
University of California, Davis
2023
University of California, Berkeley
2023
Kaiser Permanente Walnut Creek Medical Center
2023
Colorado Permanente Medical Group
2023
City College of San Francisco
2020
Huntsman Cancer Institute
2018
University of Utah
2018
UCLA Health
2013-2017
Deciphering the shared genetic basis of distinct cancers has potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we undertake genome-wide association studies (GWAS) comprehensive evaluations heritability pleiotropy across 18 cancer types in two large, population-based cohorts: UK Biobank (408,786 European ancestry individuals; 48,961 cases) Kaiser Permanente Genetic Epidemiology Research on Adult Health Aging cohorts (66,526 16,001...
Abstract Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic scores (PRS) provide personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases), we quantify added predictive value integrating cancer-specific PRS with family history modifiable factors 16 cancers. We show incorporating measurably improves prediction accuracy most cancers,...
Abstract INTRODUCTION We evaluated the independent associations between high‐density lipoprotein cholesterol (HDL‐C) and triglyceride (TG) levels with Alzheimer's disease related dementias (ADRD). METHODS Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs HDL‐C conditional age, sex, body mass index. included these residuals individually concurrently in Cox models predicting ADRD incidence. RESULTS Low (hazard ratio [HR]...
Background: The literature on traffic-related air pollution and childhood cancers is inconclusive, little known rarer cancer types.Objectives: We sought to examine associations between exposure.Methods: present study included children < 6 years of age identified in the California Cancer Registry (born 1998–2007) who could be linked a birth certificate (n = 3,590). Controls were selected at random from birthrolls 80,224). CAlifornia LINE Source Dispersion Modeling, version 4 (CALINE4) was...
<h3>Background and Objectives:</h3> The associations of high- low-density lipoprotein cholesterol (HDL-C LDL-C) with dementia risk in later life may be complex, few studies have sufficient data to model non-linearities or adequately adjust for statin use. We evaluated the observational HDL-C LDL-C incident a large well-characterized cohort linked survey electronic health record (EHR) data. <h3>Methods:</h3> Kaiser Permanente Northern California plan members aged 55 years older who completed...
Abstract Background Rhabdoid tumors are a rare and aggressive cancer subtype which is usually diagnosed in early childhood. Little known about their etiology. The purpose of this study was to describe the epidemiology rhabdoid examine relation perinatal characteristics. Methods We identified 44 atypical teratoid/rhabdoid (AT/RT) central nervous system (CNS) 61 sarcomas (renal extra‐renal non‐CNS tumors) from California Cancer Registry records diagnoses 1988–2007 among children <6 years...
Migraine is common among people with multiple sclerosis (MS), but the reasons for this are unknown. We tested 3 hypothesized mechanisms observed comorbidity, including migraine a risk factor of MS, genetic variants shared between conditions, and because MS.Data were from 2 sources: publicly available summary statistics genome-wide association studies MS (N = 115,748) 375,752 N 361,141) case-control study recruited Kaiser Permanente Northern California Health Plan 1,991). For latter...
Abstract Here we train cis -regulatory models of prostate tissue gene expression and impute transcriptome-wide for 233,955 European ancestry men (14,616 cancer (PrCa) cases, 219,339 controls) from two large cohorts. Among 12,014 genes evaluated in the UK Biobank, identify 38 associated with PrCa, many replicating Kaiser Permanente RPGEH. We report association elevated TMPRSS2 increased PrCa risk (independent a previously-reported variant) tumoral : ERG fusion-oncogene The Cancer Genome...
Abstract INTRODUCTION Mixed evidence on how statin use affects risk of Alzheimer's disease and related dementias (ADRD) may reflect heterogeneity across sociodemographic factors. Few studies have sufficient power to evaluate effect modifiers. METHODS Kaiser Permanente Northern California (KPNC) members ( n = 705,061; 202,937 with surveys) who initiated statins from 2001 2010 were matched age low‐density lipoprotein cholesterol (LDL‐C) non‐initiators followed through 2020 for incident ADRD....
Abstract Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD also a prostate cancer (PC) require further investigation. We studied 218 084 men in the population‐based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow‐up through mid‐2015. assessed association subsequent PC using multivariable Cox regression analyses, adjusting age assessment, ethnic group, region, smoking status, alcohol drinking...
Introduction Cataract is the leading cause of blindness among elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%. To date, 55 loci have been identified by genome-wide association (GWAS), however, much work remains identify causal genes. Here, we conducted a transcriptome-wide study (TWAS) prioritize genes novel ones, examine impact their expression. Methods We performed tissue-specific...
Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for cancer, many men on AS eventually convert to treatment. PC is one most heritable cancers, and genetic factors that predispose aggressive tumors help distinguish who more likely discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) 5,222 patients...
No AccessJournal of UrologyAdult Urology1 Nov 2021Factors Associated with Time to Conversion from Active Surveillance Treatment for Prostate Cancer in a Multi-Institutional CohortThis article is commented on by the following:Editorial Comment Lauren Folgosa Cooley, Adaeze A. Emeka, Travis J. Meyers, Phillip R. Cooper, Daniel W. Lin, Antonio Finelli, James Eastham, Christopher Logothetis, Leonard S. Marks, Danny Vesprini, Larry Goldenberg, Celestia Higano, Christian P. Pavlovich, June M....
Genome-wide association studies (GWASs) have identified more than 130 genetic susceptibility loci for migraine; however, how most of these impact migraine development is unknown. To identify novel genes associated with and interpret the transcriptional products those genes, we conducted a transcriptome-wide study (TWAS). We performed tissue-specific multi-tissue TWAS analyses to assess associations between imputed gene expression from 53 tissues using FUSION software. Meta-analyzed GWAS...
The development of comprehensive measures for tobacco exposure is crucial to specify effects on disease and inform public health policy. In this population-based case-control study, we evaluated the associations between cumulative lifetime cigarette tar cancers lung upper aerodigestive tract (UADT). study included 611 incident cases cancer; 601 UADT (oropharyngeal, laryngeal esophageal cancers); 1,040 cancer-free controls. We estimated based concentrations abstracted from government records...
Background Adverse childhood experiences are demonstrated risk factors for depression, a common co-morbidity of multiple sclerosis, but understudied among people with sclerosis. Objective Estimate the association between adverse and depression 1,990 adults Methods Participants were members Kaiser Permanente Northern California from two studies 2006 2021 diagnosed sclerosis by neurologist. assessed using instruments, including Behavioral Risk Factor Surveillance System. self-reported ever...
ABSTRACT Genetic factors that influence etiologic mechanisms shared across cancers could affect the risk of multiple cancer types. We investigated polygenic score (PRS)-specific pleiotropy 17 in two large population-based cohorts. The study population included European ancestry individuals from Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) UK Biobank (48,969 359,802 controls). selected known independent variants published GWAS to construct a PRS for...
Abstract Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for cancer, many men on AS eventually convert to treatment. PC is one most heritable cancers, and genetic factors that predispose aggressive tumors help distinguish who more likely discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) 6,361...
Abstract Deciphering the shared genetic basis of distinct cancers has potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. However, no studies have investigated pan-cancer pleiotropy within single, well-defined populations unselected for phenotype. We undertook novel genome-wide association (GWAS) comprehensive evaluations heritability across 18 cancer types in two large, population-based cohorts: UK Biobank (413,870 European ancestry...