A5027840333- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Pulmonary Hypertension Research and Treatments
- Urological Disorders and Treatments
- Genetic Associations and Epidemiology
- Gastric Cancer Management and Outcomes
- Pediatric Urology and Nephrology Studies
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Vascular Anomalies and Treatments
- Fungal Biology and Applications
- Gallbladder and Bile Duct Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Urinary and Genital Oncology Studies
- Global Cancer Incidence and Screening
- Biomedical Research and Pathophysiology
The University of Melbourne
2018-2025
The Royal Melbourne Hospital
2013-2022
Western Health
2022
Prostate Cancer Foundation of Australia
2018
Royal Adelaide Hospital
2012
Jensen Hughes (United States)
2011
University Kebangsaan Malaysia Medical Centre
2008
Stahl-Zentrum (Germany)
2005
University of Hong Kong
2005
Long Island Jewish Medical Center
1995
Abstract Newly diagnosed prostate cancers differ dramatically in mutational composition and lethality. The most accurate clinical predictor of lethality is tumor tissue architecture, quantified as grade. To interrogate the evolutionary origins cancer heterogeneity, we analyzed 666 whole genomes. We identified a compendium 223 recurrently mutated driver regions, influencing downstream processes gene expression. validated individual germline variants that predispose tumors to acquire specific...
Abstract Introduction Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). We sought to quantify survival and determine factors predictive cohort patients with CTD-associated PAH (CTD-PAH) the current era advanced therapy. Methods Patients right heart catheter proven CTD-PAH were recruited from six specialised treatment centres across Australia followed prospectively. Using methods including Cox proportional hazards regression, we modelled...
Abstract Background DNA originating from degenerate tumour cells can be detected in the circulation many types, where it used as a marker of disease burden well to monitor treatment response. Although circulating (ctDNA) measurement has prognostic/predictive value metastatic prostate cancer, its utility localised is unknown. Methods We performed whole-genome sequencing tumour-normal pairs eight patients with clinically undergoing prostatectomy, identifying high confidence genomic...
Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for cancer, many men on AS eventually convert to treatment. PC is one most heritable cancers, and genetic factors that predispose aggressive tumors help distinguish who more likely discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) 5,222 patients...
Microalbuminuria (MA) is a risk marker for diabetic nephropathy and cardiovascular (CV) disease (CVD) in patients with diabetes. This study aimed to describe the prevalence of albuminuria, CV factors, treatments renal protection an Asian population type 2 diabetes.This cross-sectional conducted eight countries enrolled normotensive/hypertensive adults diabetes without known proteinuria and/or non-diabetic kidney disease. Exclusion criteria were 1 diabetes, menstruation, pregnancy, acute...
Prostate cancer is a leading cause of morbidity and cancer-related death worldwide. Androgen deprivation therapy (ADT) the cornerstone management for advanced disease. The use these therapies associated with multiple side effects, including metabolic syndrome truncal obesity. At same time, obesity has been both prostate development disease progression, linked to its effects on chronic inflammation at tissue level. connection between ADT, obesity, progression well established in clinical...
Gallstone recurrence after cholecystolithotomyRG Gibney, K Chow, CB So, VA Rowley, PL Cooperberg and HJ BurhenneAudio Available | Share
Background The aim of this study was to describe our initial Australian single surgeon experience with robotic‐assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) compare the outcomes open (ORC). Methods Between January 2014 June 2016, consecutive patients diagnosed muscle invasive high‐risk non‐muscle bladder cancer undergoing were included. Treatment modalities included either RARC ICUD or ORC. consisted ileal conduit orthotopic neobladder formation....
Androgen receptor (AR) signaling is important in prostate cancer progression, and therapies that target this pathway have been the mainstay of treatment for advanced disease over 70 years. Tumors eventually progress despite castration through a number well-characterized mechanisms; however, little known about what determines magnitude response to short-term inhibition.We evaluated novel combination AR-targeting (degarelix, abiraterone, bicalutamide) noted objective patient therapy was highly...
Proteins and peptide bound polysaccharides (PSP) extracted from Basidiomycetous fungi are widely used in cancer immunotherapy recently demonstrated to induce apoptosis cells vitro. In order provide the molecular pharmacological mechanisms of PSP on human cells, we investigated gene expression profiles PSP-treated apoptotic promyelotic leukemic HL-60 using ResGen 40k IMAGE printed cDNA microarray. total 378 111 transcripts were identified as differentially expressed by at least a factor 2 or...
To investigate the utility of Magnetic Resonance Imaging (MRI) for prostate cancer diagnosis in Australian setting.All consecutive men who underwent a biopsy (transperineal or transrectal) at Royal Melbourne Hospital between July 2017 to June 2019 were included, totalling 332 patients. Data retrospectively collected from patient records. For each individual patient, risk based on clinical findings was determined using European Randomized study Screening Prostate Cancer (ERSPC) calculator,...
Abstract Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for cancer, many men on AS eventually convert to treatment. PC is one most heritable cancers, and genetic factors that predispose aggressive tumors help distinguish who more likely discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) 6,361...
Obesity is linked with more aggressive prostate cancer and higher rates of disease recurrence post treatment. It unclear if this due to specific tumor-promoting effects obesity or diagnostic bias. Patients undergoing prostatectomy were categorized according their body mass index (BMI). Expected prostate-specific antigen (PSA) levels calculated for each patient based on tumor characteristics. The effect the accuracy pre-treatment risk categorization was determined, mediation analysis used...
Objective To characterise the pattern of late biochemical recurrence (BCR) in largest contemporary cohort patients with localised prostate cancer treated radical prostatectomy (RP) active surveillance era. Patients and methods Consecutive who underwent RP for between 2003 2017 were identified from a prospectively recorded, dedicated database. received neoadjuvant androgen‐deprivation therapy excluded. These categorised into following groups: no BCR, BCR at <12 months (early), 12–60...
Abstract Background Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses cells alone has been very limited. A deeper understanding the tumour microenvironment needed to identify key drivers disease progression and reveal novel therapeutic opportunities. Results In this study, experimental enrichment selected cell-types, development a Bayesian inference model for continuous differential transcript abundance,...
To evaluate radiologic findings of Helicobacter pylori (H. pylori) in the upper gastrointestinal (UGI) tract, we retrospectively reviewed consecutive records 676 symptomatic adults with gastric biopsies (224 positive) and 150 rapid urease tests (57 positive). All UGI series patients positive or for H. were compared negative tests. examinations evaluated blindly by two radiologists without knowledge clinical findings, original interpretations, test results. They agreed that 8 18 (44%) UGIs...
To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess incidence postoperative sepsis, correlate development sepsis with presence preoperative ESBL on rectal swabs, and adequacy prophylactic antibiotic guidelines context local prevalence.Patients ultrasonography (TRUS)-guided biopsy at Royal Melbourne Hospital between January 2012 July 2016 had swabs taken immediately prior TRUS specific cultures identify ESBL....