A5057967476- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Urinary and Genital Oncology Studies
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Cell death mechanisms and regulation
- HER2/EGFR in Cancer Research
- Esophageal Cancer Research and Treatment
- Genital Health and Disease
- Urological Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Mental Health Treatment and Access
Walter and Eliza Hall Institute of Medical Research
2017-2024
Victorian Comprehensive Cancer Centre
2019-2023
The University of Melbourne
2015-2023
University of Nottingham
2021
Queen's University Belfast
2012-2017
The University of Texas Southwestern Medical Center
2017
National University of Ireland
2013
Jacksonville University
2011
Kaiser Permanente South San Francisco Medical Center
2010
Antibody charge variants have gained considerable attention in the biotechnology industry due to their potential influence on stability and biological activity. Subtle differences relative proportions of are often observed during routine biomanufacture or process changes pose a challenge demonstrating product comparability. To gain further insights into impact activity pharmacokinetics (PK) monoclonal antibody (mAb) heterogeneity, we isolated major forms recombinant humanized IgG1 compared...
Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression FLIP, which blocks extrinsic apoptotic pathway inhibiting caspase-8 activation, has been identified in various cancers. We investigated FLIP and procaspase-8 expression NSCLC effect HDAC inhibitors on expression, activation drug resistance normal line models. Immunohistochemical analysis cytoplasmic nuclear protein was carried out using a novel digital pathology approach. Both...
Objective Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and base excision gene MUTYH underlie hereditary colorectal cancer (CRC) polyposis syndromes. We evaluated robustness discriminatory potential of tumour mutational signatures CRCs for identifying germline PV carriers. Design Whole-exome sequencing formalin-fixed paraffin-embedded (FFPE) CRC tissue was performed on 33 MMR carriers, 12 biallelic 25 sporadic MLH1 methylated MMR-deficient (MMRd controls) 160...
Abstract Routine screening of tumors for DNA mismatch repair (MMR) deficiency (dMMR) in colorectal (CRC), endometrial (EC) and sebaceous skin (SST) leads to a significant proportion unresolved cases classified as suspected Lynch syndrome (SLS). SLS (n = 135) were recruited from Family Cancer Clinics across Australia New Zealand. Targeted panel sequencing was performed on tumor 137; 80×CRCs, 33×ECs 24xSSTs) matched blood-derived assess microsatellite instability status, mutation burden,...
Data suggest aspirin improves survival in colorectal cancer (CRC) harbouring PIK3CA mutations. The impact of is thought predominantly to be through an anti-inflammatory effect. aim this study explore the effect use on a real-world cohort stage 2 colon (CC) patients.A prospective CRC database identified patients diagnosed with CC between 2000 and 2011. mutation status was determined by next generation sequencing. Neutrophil-lymphocyte ratio greater than 5 at diagnosis represented systemic...
Patients in whom mismatch repair (MMR)-deficient cancer develops the absence of pathogenic variants germline MMR genes or somatic hypermethylation MLH1 gene promoter are classified as having suspected Lynch syndrome (SLS). Germline whole-genome sequencing (WGS) and targeted genome-wide tumor were applied to identify underlying cause deficiency SLS. WGS was performed on samples from 14 cancer-affected patients with SLS, including two sets first-degree relatives. assessed for variants, complex...
Modern cancer research on prognostic and predictive biomarkers demands the integration of established emerging high‐throughput technologies. However, these data are meaningless unless carefully integrated with patient clinical outcome epidemiological information. Integrated datasets hold key to discovering new therapeutic targets in cancer. We have developed a novel approach set methods for integrating interrogating phenomic, genomic sets facilitate biomarker discovery stratification....
Background Immunotherapy has demonstrated limited activity in prostate cancer to date. This likely reflects an immune suppressive tumor microenvironment (TME), with previous studies suggesting low PD-L1 expression and a sparse cell infiltrate. We aimed further characterise the TME primary correlate subset densities clinical outcomes. Methods Two distinct cohorts of patients treated radical prostatectomy were identified, based on development biochemical recurrence (BCR), one subgroup high...
Routine screening of tumors for DNA mismatch repair (MMR) deficiency (dMMR) in colorectal (CRC), endometrial (EC) and sebaceous skin (SST) leads to a significant proportion unresolved cases classified as suspected Lynch syndrome (SLS). SLS (n=135) were recruited from Family Cancer Clinics across Australia New Zealand. Targeted panel sequencing was performed on tumor (n=137; 80xCRCs, 33xECs 24xSSTs) matched blood-derived assess microsatellite instability status, mutation burden, COSMIC...
In this study, we developed an image analysis algorithm for quantification of two potential apoptotic biomarkers in non-small-cell lung cancer (NSCLC): FLIP and procaspase-8. Immunohistochemical expression procaspase-8 184 NSCLC tumors were assessed. Individual patient cores segmented classified as tumor stroma using the Definiens Tissue Studio. Subsequently, chromogenic each biomarker was measured separately nucleus cytoplasm reported a quantitative histological score. The software package...
Abstract Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. We assessed features, individually and in combination, whole-exome sequenced (WES) colorectal cancers (CRCs) panel CRCs, endometrial (ECs) sebaceous skin tumors (SSTs) their accuracy detecting dMMR. CRCs (n=300) with WES, where MMR status was determined by immunohistochemistry, were microsatellite instability (MSMuTect, MANTIS, MSIseq, MSISensor), COSMIC mutational signatures (TMS) somatic...
ABSTRACT Objective Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and base excision gene MUTYH underlie hereditary colorectal cancer (CRC) polyposis syndromes. We evaluated robustness discriminatory potential of tumour mutational signatures CRCs for identifying germline PV carriers. Design Whole exome sequencing formalin-fixed paraffin embedded (FFPE) CRC tissue was performed on 33 MMR carriers, 12 biallelic 25 sporadic MLH1 methylated MMR-deficient (MMRd controls)...
You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma I1 Apr 2017MP71-06 PROGNOSTIC SIGNIFICANCE OF EZH2 EXPRESSION IN UPPER TRACT UROTHELIAL CARCINOMA Ahmet Aydin, Nirmish Singla, Vandana Panwar, Ryan Hutchinson, Solomon Woldu, Christopher Wood, Jose Karam, Alon Weizer, Jay Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur Sagalowsky, Shahrokh Shariat, Yair Lotan, Aditya Bagrodia, Payal...