A5103927025- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Renal and related cancers
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- Urinary Tract Infections Management
- Colorectal Cancer Screening and Detection
- Urologic and reproductive health conditions
- Ureteral procedures and complications
- Diversity and Career in Medicine
- MRI in cancer diagnosis
- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Minimally Invasive Surgical Techniques
Penn State Milton S. Hershey Medical Center
2016-2025
Pennsylvania State University
2016-2025
The University of Texas Southwestern Medical Center
2008-2024
GTx (United States)
2024
Southwestern Medical Center
2009-2024
INTI International University
2024
Florey Institute of Neuroscience and Mental Health
2024
Cancer Institute (WIA)
2007-2021
Austin Hospital
2006-2021
University of Florence
2021
The literature on upper tract urothelial carcinoma (UTUC) has been limited to small, single center studies. A large series of patients treated with radical nephroureterectomy for UTUC were studied, and variables associated poor prognosis identified.Data 1363 at 12 academic centers collected. All pathologic slides re-reviewed by genitourinary pathologists according strict criteria.Pathologic review revealed renal pelvis location (64%), necrosis (21.6%), lymphovascular invasion (LVI) (24.8%),...
Study Type – Prognosis (retrospective cohort) Level of Evidence 2b What’s known on the subject? and What does study add? Upper‐tract urothelial carcinoma (UTUC) is a relatively uncommon urological malignancy with survival outcomes data largely determined from single‐centre series which can be limited by small case numbers. Through review large population based cohort, this provides valuable information regarding epidemiological patterns for over 13,000 patients UTUC diagnosed past three...
Purpose To assess the association of lymphovascular invasion (LVI) with cancer recurrence and survival in a large international series patients treated radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC). Patients Methods Data were collected on 1,453 RNU at 13 academic centers combined into relational database. Pathologic slides rereviewed by genitourinary pathologists according to strict criteria. LVI was defined as presence tumor cells within an...
Abstract The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed NMIBC ( n = 834). Transcriptomic identifies four classes (1, 2a, 2b and 3) reflecting tumor biology disease aggressiveness. Both transcriptome-based subtyping the level chromosomal instability provide independent prognostic value beyond established...
Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does study add? Accurate preoperative staging for upper‐tract urothelial carcinoma (UTUC) lesions is presently limited. Urinary cytology has shown promise characterizing pathological features bladder cancer. The role UTUC at present poorly defined. In this large multi‐institutional cohort patients, urinary was limited in its ability to accurately predict grade stage lesions. Selective ureteral...
The purpose of this guideline is to provide a useful reference on the effective evidence-based diagnoses and management non-metastatic upper tract urothelial carcinoma (UTUC).The Pacific Northwest Evidence-based Practice Center Oregon Health & Science University (OHSU) team conducted searches in Ovid MEDLINE (1946 March 3rd, 2022), Cochrane Central Register Controlled Trials (through January Database Systematic Reviews 2022). were updated August 2022. When sufficient evidence existed, body...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2002AROMATASE INHIBITORS FOR MALE INFERTILITY Jay D. Raman, and Peter N. Schlegel RamanJay Raman , SchlegelPeter View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69099-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Testosterone-to-estradiol ratio levels in infertile men improve during treatment with the...
We determined the standardized incidence ratio of testicular cancer in infertile men presenting with an abnormal semen analysis compared to general population.The charts from more than 3,800 infertility and during a 10-year period were retrospectively reviewed. The tumors diagnosed this group was that race age matched controls same population (as reported by Surveillance, Epidemiology End Results [SEER] database).Of 3,847 10 (0.3%) tumors. Mean patient 32.6 years (range 25 52) all...
To prospectively compare perioperative and pathological outcomes in a consecutive series of patients undergoing radical cystectomy (RC) urinary diversion by the open or robotic approach.From February 2006 to April 2007, 54 underwent RC one surgeon at our institution. Twenty-one were open, while 33 utilized da Vinci system (Intuitive Surgical, Sunnyvale, CA, USA). Data was collected prospectively, including patient demographics, operative postoperative variables, outcomes.The cohort had...
We evaluated the value of hydronephrosis, ureteroscopic biopsy grade and urinary cytology to predict advanced upper tract urothelial carcinoma.We reviewed charts 469 patients with carcinoma treated radical nephroureterectomy or distal ureterectomy. Complete data on hydronephrosis (present vs absent), (high low) (positive negative) were available in 172 patients. The outcome was muscle invasive (pT2-pT4) nonorgan confined (pT3 greater, lymph node metastasis) carcinoma.Of 92 (54%) had 74 (43%)...
There is relatively little literature on adjuvant chemotherapy after radical nephroureterectomy in patients with upper tract urothelial carcinoma. We determined the incidence of high risk and ensuing effect overall cancer specific survival.Using an international collaborative database we identified 1,390 who underwent for nonmetastatic carcinoma between 1992 2006. Of these cases 542 (39%) were classified as (pT3N0, pT4N0 and/or lymph node positive). These divided into 2 groups, including...
Long-term oncologic outcomes for renal thermal ablation are limited. The authors of this report present their experience with radiofrequency (RFA) therapy 243 small masses (SRMs) over the past 7.5 years.The authors' institutional, prospectively maintained RFA database was reviewed to determine intermediate and long-term patients SRMs (generally < 4 cm) who underwent RFA. Particular attention placed on had a minimum 3 years follow-up. Patients were excluded from analysis if they received...
We created a prognostic tool for the accurate preoperative prediction of nonorgan confined upper tract urothelial carcinoma.A computerized data bank containing comprehensive information on 1,453 patients who underwent radical nephroureterectomy at 13 academic institutions was generated and continuously updated. This study comprised subset 659 in whom all appropriate variables (age, gender, race, symptoms, Eastern Cooperative Oncology Group performance status, primary tumor location,...
We examined the impact of lymphadenectomy on clinical outcomes patients with upper tract urothelial cancer treated radical nephroureterectomy.Data were collected 1,130 consecutive pT1-4 nephroureterectomy at 13 centers worldwide. Patients grouped according to nodal status (pN0 vs pNx pN+). The choice perform was determined by treating surgeon. All pathology slides reevaluated dedicated genitourinary pathologists. Univariable and multivariable Cox regression models measured association pN+)...
We reviewed the natural history of residual fragments after percutaneous nephrostolithotomy.From April 1999 to January 2007 a total 728 patients underwent nephrostolithotomy at our medical center including 527 with minimum documented radiographic followup 6 months. Of these 42 (8%) on postoperative computerized tomography were observed rather than subjected second look flexible nephroscopy. Computerized was define location, size and number fragments. The primary study end point stone related...
Abstract Purpose: The Polycomb group gene, EZH2, functions as a transcriptional repressor involved in gene silencing. Amplification of EZH2 has been reported several malignancies, including prostate, breast, and lymphoma. We evaluated mRNA protein expression bladder specimens from patients the five cancer cell lines. Experimental Design: was assessed by reverse transcription-PCR (RT-PCR) 38 tissue specimens. also 39 for using immunohistochemistry with affinity-purified antibodies to human...