Peter N. Schlegel

ORCID: 0000-0002-7129-8137
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About
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Research Areas
  • Sperm and Testicular Function
  • Sexual Differentiation and Disorders
  • Reproductive Biology and Fertility
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Reproductive Health and Technologies
  • Testicular diseases and treatments
  • Male Reproductive Health Studies
  • Hormonal and reproductive studies
  • Assisted Reproductive Technology and Twin Pregnancy
  • Urologic and reproductive health conditions
  • Prostate Cancer Diagnosis and Treatment
  • Urological Disorders and Treatments
  • Ovarian function and disorders
  • Prostate Cancer Treatment and Research
  • Renal and related cancers
  • Sexual function and dysfunction studies
  • Prenatal Screening and Diagnostics
  • Genital Health and Disease
  • Urinary Bladder and Prostate Research
  • Ocean Acidification Effects and Responses
  • Pediatric Urology and Nephrology Studies
  • Chromosomal and Genetic Variations
  • Ureteral procedures and complications
  • Estrogen and related hormone effects
  • Ubiquitin and proteasome pathways

Gay Men's Health Crisis
2025

NewYork–Presbyterian Hospital
2014-2024

Cornell University
2015-2024

Weill Cornell Medicine
2016-2024

New York Hospital Queens
2014-2024

Presbyterian Hospital
2014-2024

Reproductive Medicine Institute
2009-2024

Hôpital Foch
2022

RELX Group (United States)
2019-2021

Software (Spain)
2020

Testicular sperm extraction (TESE) may provide spermatozoa for attempts at fertility with assisted reproduction; however, the physiological effects of TESE on testicular function are not well understood. In order to evaluate testis, 64 patients were evaluated after non-obstructive azoospermia physical examinations, serial scrotal sonography, histological analyses and evaluation success repeated retrieval attempts. At 3 months TESE, 82% had ultrasonographic abnormalities in testis suggesting...

10.1093/humrep/12.8.1688 article EN Human Reproduction 1997-08-01

New York City was the international epicenter of COVID-19 pandemic. Health care providers responded by rapidly transitioning from in-person to video consultations. Telemedicine (ie, visits) is a potentially disruptive innovation; however, little known about patient satisfaction with this emerging alternative traditional clinical encounter.This study aimed determine if differs between and visits.In retrospective observational cohort study, we analyzed 38,609 Press Ganey survey outcomes clinic...

10.2196/20786 article EN cc-by Journal of Medical Internet Research 2020-08-06

Y chromosome microdeletions are associated with severe male factor infertility. In this study, the success rate of testicular sperm retrieval was determined for men deletions AZF regions a, b or c.AZF were detected by PCR 30 sequence-tagged sites within Yq emphasizing AZFa, and c regions. Semen analysis diagnostic testis biopsy extraction (TESE) findings correlated specific region deleted.A total 78 included three AZFa deletion, 11 AZFb, 42 AZFc, 16 AZFb+c six (AZFa+b+c). All azoospermic no...

10.1093/humrep/deg348 article EN Human Reproduction 2003-07-18

We examined preoperative factors that could predict successful microdissection testicular sperm extraction in men with azoospermia and nonmosaic Klinefelter's syndrome. also analyzed the influence of hormonal therapy on retrieval rate.A total 91 attempts were done 68 Men serum testosterone less than 300 ng/dl received medical aromatase inhibitors, clomiphene or human chorionic gonadotropin before extraction. Preoperative patient age endocrinological data compared those whom procedure was not...

10.1016/j.juro.2009.05.019 article EN The Journal of Urology 2009-07-19

The summary presented herein represents Part I of the two-part series dedicated to Diagnosis and Treatment Infertility in Men: AUA/ASRM Guideline. outlines appropriate evaluation male an infertile couple. Recommendations proceed from obtaining history physical exam (Appendix I), as well diagnostic testing, where indicated.The Emergency Care Research Institute Evidence-based Practice Center team searched PubMed®, Embase®, Medline January, 2000 through May, 2019. When sufficient evidence...

10.1097/ju.0000000000001521 article EN The Journal of Urology 2020-12-09

The summary presented herein represents Part II of the two-part series dedicated to Diagnosis and Treatment Infertility in Men: AUA/ASRM Guideline. outlines appropriate management male an infertile couple. Medical therapies, surgical techniques, as well use intrauterine insemination (IUI)/in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) are covered allow for optimal patient management. Please refer I discussion on evaluation relevant health conditions that associated with...

10.1097/ju.0000000000001520 article EN The Journal of Urology 2020-12-09

Abstract De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness. We hypothesize that de an important severe male infertility and explain portion of the genetic causes this understudied disorder. To test hypothesis, we utilize trio-based exome sequencing cohort 185 infertile males their unaffected parents. Following systematic analysis, 29 145 rare (MAF < 0.1%) protein-altering classified as possibly causative phenotype. observed significant...

10.1038/s41467-021-27132-8 article EN cc-by Nature Communications 2022-01-10

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2002AROMATASE INHIBITORS FOR MALE INFERTILITY Jay D. Raman, and Peter N. Schlegel RamanJay Raman , SchlegelPeter View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69099-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Testosterone-to-estradiol ratio levels in infertile men improve during treatment with the...

10.1016/s0022-5347(01)69099-2 article EN The Journal of Urology 2002-02-01

Purpose: The aim of this study was to report the successful fertility treatment men with Klinefelter syndrome using testicular sperm extraction (TESE) and intracytoplasmic injection (ICSI). Methods: A total 42 who underwent 54 TESE procedures were identified. Before TESE, patients serum testosterone levels less than 15.6 nmol/liter treated an aromatase inhibitor. Sperm retrieval rates results ICSI, including fertilization clinical pregnancy, collected. Results: Mean pretreatment FSH 33.2...

10.1210/jc.2004-2322 article EN The Journal of Clinical Endocrinology & Metabolism 2005-11-01

No AccessJournal of Urology1 Dec 1987Neuroanatomical Approach to Radical Cystoprostatectomy with Preservation Sexual Function Peter N. Schlegel and Patrick C. Walsh SchlegelPeter WalshPatrick View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43655-XAboutPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The technique for radical cystoprostatectomy has been modified avoid injury the branches pelvic plexus that innervate...

10.1016/s0022-5347(17)43655-x article EN The Journal of Urology 1987-12-01

To provide fertility for men with nonobstructive azoospermia.A retrospective review of treatment results at a university infertility center was undertaken. Sixteen couples entered an attempted in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) cycle azoospermia. Each man azoospermic, and the male factor diagnosis azoospermia made on testis biopsy 14 clinical grounds 2 men. Sperm were retrieved by testicular day oocyte retrieval. Results examinations, serum...

10.1016/s0090-4295(97)00032-0 article EN cc-by-nc-nd Urology 1997-05-01

We establish whether a subset of infertile men have decreased serum testosterone-to-estradiol ratios and this condition can be corrected with an oral aromatase inhibitor.The 63 severe male factor infertility or hypergonadotropic hypogonadism (mean follicle-stimulating hormone 21.2 +/- 1.8) were compared those age matched, fertile, control reference group. Of the 43 azoospermic biopsy proved 20 oligospermic. The lowest (less than 20th percentile) treated 50 to 100 mg inhibitor testolactone...

10.1016/s0022-5347(05)66540-8 article EN The Journal of Urology 2001-03-01

Genetic abnormalities, including partial deletions of the Y-chromosome, are commonly detectable in men with non-obstructive azoospermia (NOA). NOA can be treated using testicular sperm extraction (TESE) intracytoplasmic injection (ICSI). Recent studies have shown that presence involving AZFc region do not appear to affect chance retrieving spermatozoa or a significant impact on fertilization pregnancy rates ICSI. We investigated effect Y-chromosome retrieval TESE. Eighty attempts at were...

10.1093/humrep/13.10.2812 article EN Human Reproduction 1998-10-01

No AccessJournal of UrologyCLINICAL UROLOGY: Special Communications1 May 2002Best Practice Policies for Male Infertility JONATHAN P. JAROW, IRA D. SHARLIP, ARNOLD M. BELKER, LARRY I. LIPSHULTZ, MARK SIGMAN, ANTHONY J. THOMAS, PETER N. SCHLEGEL, STUART S. HOWARDS, AJAY NEHRA, MARIAN DAMEWOOD, JAMES W. OVERSTREET, RICHARD SADOVSKY, and the MALE INFERTILITY BEST PRACTICE POLICY COMMITTEE OF THE AMERICAN UROLOGICAL ASSOCIATION INC. JAROWJONATHAN JAROW , SHARLIPIRA SHARLIP BELKERARNOLD BELKER...

10.1016/s0022-5347(05)65109-9 article EN The Journal of Urology 2002-05-01

Klinefelter's syndrome is a form of hypergonadotropic hypogonadism and infertility resulting from supernumerary X chromosome (47,XXY), with an incidence approximately 1 case in 500 phenotypic males.1,2 Some men who have chromosomal mosaicism (46,XY/47,XXY) are fertile. Men nonmosaic, or complete, usually azoospermia, only few any spermatogenesis.3,4 Intracytoplasmic sperm injection, which spermatozoon injected into ovum vitro, effective treatment for male-factor infertility. However, the...

10.1056/nejm199802263380905 article EN New England Journal of Medicine 1998-02-26

No AccessJournal of UrologyClinical Urology: Original Articles1 Jan 1999TESTICULAR SPERM EXTRACTION WITH INTRACYTOPLASMIC INJECTION FOR NONOBSTRUCTIVE AZOOSPERMIA: TESTICULAR HISTOLOGY CAN PREDICT SUCCESS OF RETRIEVAL LI-MING SU, GIANPIERO D. PALERMO, MARC GOLDSTEIN, LUCINDA L. VEECK, ZEV ROSENWAKS, and PETER N. SCHLEGEL SULI-MING SU , PALERMOGIANPIERO PALERMO GOLDSTEINMARC GOLDSTEIN VEECKLUCINDA VEECK ROSENWAKSZEV ROSENWAKS SCHLEGELPETER View All Author...

10.1016/s0022-5347(01)62079-2 article EN The Journal of Urology 1999-01-01
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