A5086644570- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Urinary Bladder and Prostate Research
- PARP inhibition in cancer therapy
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Ferroptosis and cancer prognosis
- Particle physics theoretical and experimental studies
- Esophageal Cancer Research and Treatment
- Hormonal and reproductive studies
Keio University
2016-2025
Keio University Hospital
2016-2025
Hiroshima University
2023-2024
Palacký University Olomouc
2024
Beatson West of Scotland Cancer Centre
2024
Queen Mary University of London
2024
University of Glasgow
2024
Université Paris-Saclay
2024
University College London
2024
Dana-Farber Cancer Institute
2024
Purpose To assess the association of lymphovascular invasion (LVI) with cancer recurrence and survival in a large international series patients treated radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC). Patients Methods Data were collected on 1,453 RNU at 13 academic centers combined into relational database. Pathologic slides rereviewed by genitourinary pathologists according to strict criteria. LVI was defined as presence tumor cells within an...
Abstract Context: Aldosterone synthase (CYP11B2) and steroid 11β-hydroxylase (CYP11B1) catalyze the terminal steps for aldosterone cortisol syntheses, respectively, thereby determining functional differentiation of human adrenocortical cells. Little is known, however, about how cells expressing enzymes are actually distributed in adrenals under normal pathological conditions. Objective: The objective study was to determine localization CYP11B2 -B1 adrenal specimens by using developed...
BACKGROUND: Preclinical studies and results of a phase 2 trial abiraterone olaparib suggest combined antitumor effect when the poly(adenosine diphosphate[ADP]-ribose) polymerase inhibitor is with next-generation hormonal agent to treat metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted double-blind, 3 versus placebo in patients mCRPC first-line setting. Patients were enrolled regardless homologous recombination repair gene mutation (HRRm) status. HRRm status was...
11 Background: Preclinical studies have shown combined anti-tumor effect through interactions between poly(adenosine diphosphate–ribose) polymerase and androgen receptor signaling pathways. A Phase II trial (NCT01972217) in pts with mCRPC unselected by homologous recombination repair (HRR) status who previously received docetaxel demonstrated improved radiographic progression-free survival (rPFS) for treated ola + abi vs pbo (Clarke N, 2018). The III PROpel study (NCT03732820) evaluates the...
BackgroundBelzutifan, a hypoxia-inducible factor 2α inhibitor, showed clinical activity in clear-cell renal-cell carcinoma early-phase studies.MethodsIn phase 3, multicenter, open-label, active-controlled trial, we enrolled participants with advanced who had previously received immune checkpoint and antiangiogenic therapies randomly assigned them, 1:1 ratio, to receive 120 mg of belzutifan or 10 everolimus orally once daily until disease progression unacceptable toxic effects occurred. The...
Lateral lymph node metastases occur in some patients with low rectal cancer and may cause local recurrence after total mesorectal excision. The aims of this study were to identify risk factors for lateral pathological tumour (pT) stage 3 or pT4 adenocarcinoma, evaluate the prognostic significance metastases.A retrospective analysis was performed outcome 237 pT3 adenocarcinoma who underwent R0 resection systematic dissection.Lateral found 41 (17.3 per cent). Increased associated a distal...
There is relatively little literature on adjuvant chemotherapy after radical nephroureterectomy in patients with upper tract urothelial carcinoma. We determined the incidence of high risk and ensuing effect overall cancer specific survival.Using an international collaborative database we identified 1,390 who underwent for nonmetastatic carcinoma between 1992 2006. Of these cases 542 (39%) were classified as (pT3N0, pT4N0 and/or lymph node positive). These divided into 2 groups, including...
Hypericin from Hypericum perforatum was found to inhibit in vitro type A and B monoamine oxidase (MAO's) prepared by treating rat brain mitochondria with selective inhibitors. The inhibition of MAO hypericin higher than that MAO. almost irreversible for both types.
No AccessJournal of UrologyAdult Urology1 May 2011Preoperative Hydronephrosis Grade Independently Predicts Worse Pathological Outcomes in Patients Undergoing Nephroureterectomy for Upper Tract Urothelial Carcinoma Yujiro Ito, Eiji Kikuchi, Nobuyuki Tanaka, Akira Miyajima, Shuji Mikami, Masahiro Jinzaki, and Mototsugu Oya ItoYujiro Ito Department Urology, Keio University School Medicine, Tokyo, Japan , KikuchiEiji Kikuchi TanakaNobuyuki Tanaka MiyajimaAkira Miyajima MikamiShuji Mikami...
Abstract Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein overexpressed in castration-resistant (CRPC) and NEPC, but its specific role unknown. Here, we demonstrate that upregulation of androgen-dependent PC cells suppresses androgen receptor (AR) axis signaling induces the neural BRN2 transcription factor. activates a MYC→BRN2 pathway association induction MYCN, EZH2 NE differentiation markers (ASCL1, AURKA...
Tumor necrosis factor‐α (TNF‐α) is involved in epithelial‐mesenchymal transition (EMT) and expression of CD44, a cancer stem cell marker, several cancers. This study was performed to clarify the significance TNF‐α CD44 clear renal carcinomas (ccRCCs). Expression examined by immunohistochemistry 120 ccRCCs. Involvement EMT induction analyzed monitoring EMT‐related genes invasion cultured ccRCC lines. were immunolocalized mainly carcinoma cells high‐grade ccRCCs with positive correlations...
Abstract Acquisition of mesenchymal properties by cancer cells is critical for their malignant behaviour, but regulators the molecular machinery and how it activated remain elusive. Here we show that clear cell renal carcinomas (ccRCCs) frequently utilize Arf6-based pathway to promote invasion metastasis, similar breast cancers. In cells, ligand-activated receptor tyrosine kinases employ GEP100 activate Arf6, which then recruits AMAP1; AMAP1 binds mesenchymal-specific protein EPB41L5,...
The polybromo-associated PBAF (SWI/SNF) chromatin remodeling complex, which includes PBRM1, ARID2, and BRD7, regulates cell differentiation genomic integrity. MUC1-C is an oncogenic protein that drives lineage plasticity in prostate cancer (PC) progression. present work demonstrates induces BRD7 expression by the previously unrecognized E2F1-mediated activation of their respective promoters. functional significance MUC1-C→PBAF pathway supported demonstrating involvement associating with...
The aims of this study were (1) to clarify the impact tertiary lymphoid structure (TLS) status on outcome and immunogenomic profile human clear cell renal carcinoma (ccRCC) (2) determine phenotypic differences in TLSs between different types genitourinary cancer, that is, urinary ccRCC bladder cancer.We performed a quantitative immunohistological analysis tissue microarrays conducted integrated genome mutation by next-generation sequencing methylation array analysis. Since tumor immune...
ABSTRACT Introduction Avelumab, an anti‐programmed death ligand 1 antibody, was approved in combination with axitinib for curatively unresectable or metastatic renal cell carcinoma (RCC) Japan December 2019. Because the pivotal JAVELIN Renal 101 study included a limited number of Japanese patients, post‐marketing surveillance (PMS) required to evaluate outcomes (safety and effectiveness) patients RCC who received avelumab + treatment clinical practice Japan. Materials Methods We report data...
Signal transducer and activator of transcription 3 (STAT3) is known to have an important role in cytokine growth factor signaling pathways. In various types human malignant tumors STAT3 has been shown be constitutively activated due aberrant production cytokines factors. We examined the presence activation its association with pathological features clinical outcome renal cell carcinoma cases.We 48 paraffin embedded specimens corresponding nonneoplastic kidney tissues for status on...