A5041743195- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Renal and related cancers
- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Hormonal Regulation and Hypertension
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Bone health and treatments
- Renin-Angiotensin System Studies
- Radiomics and Machine Learning in Medical Imaging
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- Hormonal and reproductive studies
- Urinary Tract Infections Management
- Urinary Bladder and Prostate Research
- Advanced Radiotherapy Techniques
Edogawa Hospital
2020-2024
Tokyo Medical University
2007-2016
Keio University
1999-2011
National Defense Medical College
2005-2006
Triangle
2004
Memorial Sloan Kettering Cancer Center
1998-2000
Keio University Hospital
1995
National Chemical Laboratory
1979
The purpose of this study was to compare the accuracy CT urography and excretory for detection localization upper urinary tract urothelial carcinoma.Of 128 patients at high risk carcinoma who were examined with both between 2002 2007, 24 undiagnosed excluded. results remaining 104 552 segments compared histopathologic examination or follow-up imaging 1 year. Two readers independently scored confidence levels presence absence in each six on urography; differences resolved by consensus.Upper...
Abstract Purpose: There have been several studies on the antitumor activity of angiotensin II type 1 receptor (AT1R) antagonists. In this study, we evaluated efficacy AT1R antagonist candesartan in bladder cancer. Experimental Design: For study vitro, human cancer cells (KU-19-19) were cultured with or without and candesartan. Various cytokines cell viability analyzed. vivo, a tumor xenograft model was prepared nude mice using KU-19-19 cells. Mice given daily by oral gavage. Microvessel...
We investigated the prognostic impact of lymphovascular invasion (LVI) and traditional factors for survival in a large series patients treated surgically upper tract transitional cell carcinoma (TCC). also developed factors-based model risk stratification TCC.We identified study population 173 consecutive TCC at our institution between 1980 2002. compared LVI with other pathological features determined disease specific rate.LVI was found 52 (30.1%). As tumor grade stage increased, incidence...
ObjectiveTo assess and compare quality of life (QOL) patients followed for a long time who underwent an ileal conduit (IC), continent reservoir (CR) or neobladder (NB) using FACT-BL, bladder-cancer-specific questionnaire.
We carried out a prospective, randomized, controlled trial to investigate the efficacy and safety of both induction maintenance therapy with intravesical instillation bacillus Calmette-Guérin (BCG) for high-risk non-muscle invasive bladder cancer (NMIBC).Intravesical 80 mg Tokyo strain was given patients NMIBC, including carcinoma in situ (CIS), once weekly eight consecutive weeks as therapy. Patients who achieved complete response (CR) were randomly assigned either group or observation...
In Japan, no study has compared the perioperative outcomes observed between robot-assisted radical cystectomy (RARC) and open (ORC). This aimed at a prospective comparison of RARC ORC performed by single surgeon. Between 2008 2011, 26 bladder cancer patients underwent one surgeon, 11 robotically 15 procedure. We prospectively collected pathological data for these patients, retrospectively two different surgical procedures. The cohort had significant decrease in both estimated blood loss...
In a small pilot study, we assessed whether early-phase dynamic contrast-enhanced MDCT can be used to detect bladder tumors and thin reconstruction improves the detection rate.Thirty-six patients (30 with 59 cystoscopy-proven cancers six normal bladders) underwent of pelvis abdomen. Images were obtained from symphysis pubis diaphragm 70 seconds after injection 100 mL contrast medium. McNemar test was compare sensitivity per patient, segment, tumor specificity patient segment for each three...
The clinical value of serum tartrate-resistant acid phosphatase (TRACP), prostate specific antigen (PSA), alkaline (ALP), and prostatic (PACP) for the prediction bone metastases in cancer were investigated.TRACP, PACP, ALP, PSA levels measured 215 patients with cancer, including 160 without 55 metastases. Correlation marker was assessed using receiver operating characteristics (ROC) analysis. Sensitivity, specificity, accuracy, positive negative predictive values calculated each marker....
KU7 is a popular urothelial carcinoma cell line that was isolated from the bladder of patient at Keio University in 1980. It has subsequently been widely used laboratories around world. We describe how routine authentication revealed cross contaminated almost 30 years ago with HeLa, cervical line.Presumed clones dating 1984 to 1999 were provided by M.D. Anderson Cancer Center, Vancouver Prostate Centre, Kyoto University, Tokyo Medical and University. HeLa obtained ATCC. Genomic DNA short...
Majority of current treatment strategies against erectile dysfunction (ED) has been consisted only a supportive care to sustain enough erection during sexual intercourse. In this study, we investigated whether the cultured conditioned medium human exfoliated deciduous dental pulp stem cells (SHED-CM) had an ability treat ED through fundamentally repairing pathological damage vascular endothelial corpus cavernosum. An open-label pilot study was performed from April 2016 October 2020. SHED-CM...
Abstract Backgrounds The present study was designed to identify the preoperative parameters, including PSA‐based and endorectal MRI, predictive of pathological stage in males who underwent radical prostatectomy. Methods We studied 114 patients retropubic prostatectomy pelvic lymphadenectomy for clinically localized prostate cancer. Clinical assessed by DRE, CT scan, bone scan. correlation between clinical stage, histological findings biopsy specimens, analyzed. Logistic regression analysis...
Inducible activation of nuclear factor (NF)-κB is one the principal mechanisms through which resistant prostate cancer cells are protected from radiotherapy. We hypothesised that inactivation inducible NF-κB with a novel inhibitor, DHMEQ, would increase therapeutic effects radiotherapy.PC-3 and LNCaP were exposed to irradiation and/or DHMEQ. Cell viability, cell cycle analysis, western blotting assay, activity measured. The antitumour effect combined DHMEQ in vivo was also assessed.The...
The aim of the present study was to investigate learning curve and perioperative outcomes in 200 consecutive patients with prostate cancer who underwent robot-assisted radical prostatectomy (RARP).Between August 2006 2011, RARP were enrolled this study. We prospectively collected demographic data analyzed pathologic functional outcomes. operative total time, estimated blood loss (EBL), positive surgical margin (PSM), incontinence, complications. also evaluated relationship between surgeon's...