A5090255439- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Testicular diseases and treatments
- Renal and related cancers
- Sexual Differentiation and Disorders
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Genital Health and Disease
- Statistical Methods in Clinical Trials
- Molecular Biology Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Ureteral procedures and complications
- Venous Thromboembolism Diagnosis and Management
- Ferroptosis and cancer prognosis
Vivantes Klinikum
2025
Martini-Klinik
2013-2024
Universität Hamburg
2014-2024
University Medical Center Hamburg-Eppendorf
2014-2024
Regio Kliniken
2017-2018
University of Applied Sciences Wedel
2014-2016
Regio (Germany)
2014-2016
Southern California University for Professional Studies
2009-2015
University of Southern California
2009-2015
Neurology, Inc
2014
Study Type – Prognosis (case series) Level of Evidence 4 What’s known on the subject? and What does study add? Observations from small retrospective studies have indicated that a considerable number patients undergoing radical cystectomy for bladder cancer experience stage migration (either upstaging or downstaging) when comparing clinical pathological staging. In addition, it is unclear if an adverse prognostic feature independent stage. We report frequency downstaging using large,...
We evaluated the association of soft tissue surgical margins with characteristics and outcomes patients treated radical cystectomy for urothelial carcinoma bladder.We retrospectively collected data 4,410 pelvic lymphadenectomy without neoadjuvant chemotherapy at 12 academic centers in United States, Canada Europe. A positive margin was defined as presence tumor inked areas on specimen.Positive were identified 278 (6.3%). On univariate analysis significantly associated advanced pT stage,...
We tested whether the combination of 4 established cell cycle regulators (p53, pRB, p21 and p27) could improve ability to predict clinical outcomes in a large multi-institutional collaboration patients with pT3-4N0 or pTany Npositive urothelial carcinoma bladder. also assessed molecular markers is superior any individual biomarker.The study comprised 692 bladder treated radical cystectomy bilateral lymphadenectomy (median followup 5.3 years). Scoring was performed using advanced imaging...
OBJECTIVE To assess the magnitude of effect histological subtype (HS, three most common being clear cell, papillary and chromophobe) on cause-specific mortality (CSM) from renal cell carcinoma (RCC). PATIENTS AND METHODS Univariable multivariable Cox regression models included data 11 618 patients treated with nephrectomy between 1988 2004 in nine Surveillance Epidemiology End Results registries. We tested whether HS represents an independent predictor CSM, adds to ability other variables...
Abstract Purpose: Deletions of 8p and gains 8q belong to the most frequent cytogenetic alterations in prostate cancer. The target genes these their biological significance are unknown. Experimental Design: To determine relationship between chromosome 8 changes, cancer phenotype prognosis, a set 1.954 fully annotated cancers were analyzed tissue microarray format by fluorescence situ hybridization. Results: Both deletions increased number during different stages progression. deletions/8q...
Study Type – Therapy (outcomes research) Level of Evidence 2b What’s known on the subject? and What does study add? In current literature, cT3 stage, biopsy Gleason > 8, PSA 20 ng/ml, D’Amico high‐risk category are frequently used definitions prostate cancer. Patients with clinically localized cancer do not have a uniformly poor prognosis after surgery. The rates favourable pathological characteristics biochemical‐recurrence free survival vary depending definition for OBJECTIVE • To...
Large variability exists in the rates of perioperative mortality after cystectomy. Contemporary estimates range from 0.7% to 5.6%. We tested several predictors and devised a model for individual prediction.We relied on life tables quantify 30, 60 90-day according age, gender, stage (localized vs regional), grade, type surgery (partial radical cystectomy), year cystectomy histological bladder cancer subtype. fitted univariable multivariable logistic regression models using 5,510 patients...
To date no study to our knowledge has compared cancer control outcomes of segmental ureterectomy relative nephroureterectomy, which represents the standard care for ureteral transitional cell carcinoma. We specific mortality rates according surgery type (nephroureterectomy vs ureterectomy) in a large population based cohort patients with carcinoma.Our analyses involved 2,044 pathological T1-T4 N0M0 carcinoma from Surveillance, Epidemiology and End Results database. Survival plots Cox...
Although serum tumor markers beta human chorionic gonadotropin (bHCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH) are well-established tools for the management of testicular germ cell tumours (GCTs), there only few data from contemporary cohorts primary GCT patients regarding these biomarkers. Our aim was to evaluate marker elevations in GCTs document their associations with various clinical characteristics.A total 422 consecutive were retrospectively analysed levels bHCG, AFP,...
Objective To compare oncological, functional and surgical outcomes of open retropubic radical prostatectomy (ORP) vs robot‐assisted laparoscopic (RARP). Patients methods We identified 10 790 consecutive treated patients within our prospective database (2008–2016) who underwent either ORP (7007 patients) or RARP (3783). All procedures were performed by seven highly trained surgeons performing both approaches regularly. Oncological (48‐month biochemical recurrence [BCR] rate), (urinary...
To assess the impact of patient age on outcomes after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).Data were collected 1453 patients treated with RNU at 13 centres. Pathological slides reviewed by dedicated genitourinary pathologists according to standardized criteria. Age was analysed both as a continuous and categorical variable (<50, n = 85; 50-59.9, 229; 60-69.9, 416; 70-79.9, 523; > or =80 years, 200). RESULTS Patients aged <50 years less likely have...
The prognostic significance of renal pelvis vs ureteral upper urinary tract urothelial carcinoma tumor location is controversial. We assessed the in a large, population based data set.Our analyses relied on 2,824 patients treated with nephroureterectomy for within 9 SEER registries between 1988 and 2004. Univariable multivariable models tested effect cancer specific mortality rates. Covariates consisted age, race, registry, gender, type surgery (nephroureterectomy without bladder cuff...
Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does study add? The widespread use PSA testing resulted in a stage migration towards clinical organ‐confined prostate cancers at diagnosis during last decade. However, our large cohort demonstrates an increasing proportion patients with non‐organ confined after radical prostatectomy. These findings may be related to introduction new, non‐established treatment options for low‐risk cancer years growing...