A5080416597- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Genital Health and Disease
- Ureteral procedures and complications
- Pelvic floor disorders treatments
- Neuroblastoma Research and Treatments
- Urinary Bladder and Prostate Research
- Sperm and Testicular Function
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Urinary Tract Infections Management
- Medical Practices and Rehabilitation
- Ovarian cancer diagnosis and treatment
- Medical and Health Sciences Research
- Prostate Cancer Treatment and Research
- Trauma and Emergency Care Studies
- Urinary and Genital Oncology Studies
- Colorectal Cancer Surgical Treatments
- Sexual Differentiation and Disorders
- Streptococcal Infections and Treatments
- Female Genital Mutilation/Cutting Issues
- Lymphatic Disorders and Treatments
Asklepios Fachklinikum Brandenburg
2021-2024
Klinik und Poliklinik für Urologie
2019-2023
University Hospital in Halle
2023
Albertinen Diakoniewerk
2013-2020
Asklepios Klinik St. Georg
2017-2020
Asklepios
2018
Sankt-Antonius-Hospital Eschweiler
2009-2017
RWTH Aachen University
2009-2015
Royal Berkshire Hospital
2010
St. Antonius Ziekenhuis
2009
Previous studies suggested that serum levels of microRNA (miR)-371a-3p (so-called M371 test) have a much higher sensitivity and specificity than the classic markers testicular germ cell tumors (GCTs) are applicable toward both seminoma nonseminoma. We sought to confirm usefulness this test as novel biomarker for GCT.
Although serum tumor markers beta human chorionic gonadotropin (bHCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH) are well-established tools for the management of testicular germ cell tumours (GCTs), there only few data from contemporary cohorts primary GCT patients regarding these biomarkers. Our aim was to evaluate marker elevations in GCTs document their associations with various clinical characteristics.A total 422 consecutive were retrospectively analysed levels bHCG, AFP,...
Clinical characteristics of testicular germ cell tumours (GCTs) apparently change over time, and some vary geographically. The aim this study is to document the clinical profile contemporary GCT patients.Four hundred twenty-two Caucasian GCT-patients treated in one German centre during 2000-2017, were analysed terms patient-age, laterality, histology, tumour-size, stages (CS), pathological (pT)-stages serum biomarker expression. results descriptively compared with literature.Median age was...
<b><i>Background:</i></b> Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity decline in response treatment. <b><i>Patients and Methods:</i></b> Twenty-four patients with GCT (20 seminoma, 4 nonseminoma, median age 40 years) clinical stage 1 had measurements miR-371a-3p preoperatively repeatedly...
Clinical stage 1 (CS1) testicular seminoma involves an almost 100 % disease-specific survival in controlled clinical trials. We aimed to find out whether these results can be matched patients managed on the routine care level.In total, 725 with CS1 were prospectively enrolled from 130 institutions. Adjuvant management as decided by local physicians involved surveillance (n = 256), radiotherapy (41), 1× Carboplatin (362), and 2× (66). registered type of management, age, duration follow-up...
<b>Purpose:</b> To describe sonomorphological features in testicular Leydig cell tumors (LCTs) with a special focus on contrast-enhanced ultrasonography (CEUS) and real-time elastography (RTE). <b>Patients Methods:</b> In series of 186 patients surgery for neoplastic disease, 13 benign LCTs (in 12 patients) were histopathologically diagnosed. Preoperatively, all had been examined standardized protocol (high-resolution grayscale color-coded ultrasonography, CEUS). 5 underwent RTE. CEUS, the...
We investigated the importance of patient and tumor characteristics to predict continence, potency, physical mental health 1 year after radical prostatectomy.This prospective study included 236 patients who underwent open retropubic prostatectomy at a single institution between January 2005 October 2007. used validated questionnaires, including Short Form General Health Survey, International Index Erectile Function Consultation Incontinence Questionnaire, evaluate postoperative related...
microRNAs (miRs)-371-3 are suggested to be novel biomarkers of germ cell tumors (GCTs), but their specificity is unresolved. We aimed at clarifying the origin miR 371a-3p by measuring this in peripheral vein blood, and fluids present vicinity GCTs.miR-371a-3p levels were measured quantitative PCR 9 tumor surrounding hydroceles cubital blood (CVB) testicular (TVB) 64 GCT patients, 51 with clinical stage (CS) 1, 13 CS2-3. Thirty three CS1 cases had also postoperative CVB measurement. TVB...
The loss of a testicle to cancer involves much emotional impact young males. Little is known about the number patients with testicular germ cell tumour (GCT) who would accept prosthesis. Also, knowledge satisfaction implant recipients device limited. A retrospective chart analysis was performed on 475 consecutive GCT patients. Prior orchiectomy, all were offered prosthesis insertion. Acceptance noted along age, clinical stage, histology and year surgery. 171 interviewed using an 18 item...
<b><i>Introduction:</i></b> MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. <b><i>Patients, Methods:</i></b> In 312 consecutive cases with various testicular diseases, levels miR371a-3p were measured. Measurement results became available only after completion treatment. Five patients seminoma selected for review because...
Testicular epidermoid cysts (TECs) are rare benign testicular neoplasms. As TECs rarely associated with germ cell tumours (GCTs), the understanding of biological behaviour and clinical management TEC is unresolved.We retrospectively searched files patients treated for neoplasms cancer in time from 2000 to 2017. Those were subjected closer review looking histological features, results imaging ultrasonography (US), contrast enhanced sonography (CEUS) magnetic resonance (MRI).Among 589...
To compare earlier and later patient groups with Fournier's gangrene, specifically the incidence of rising antibiotic resistance rates in mind. Primary endpoints were to therapy, outcomes, rates.A multicentric, retrospective, multi-national study was performed. Two different time frames treatment defined: Group 1 (n = 50) 2 104). Demographics outcomes analysed using Student-t test, chi-square or Fisher exact test. Survival data estimated Kaplan Meier method compared by Log rank testing.There...
<b><i>Introduction:</i></b> Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems be a key treatment point for Fournier’s gangrene. The aim of this study was investigate the influence HBO therapy on outcome prognosis <b><i>Patients Methods:</i></b> In present multicenter, retrospective observational study, we evaluated data approximately 62 patients diagnosed with gangrene between 2007 2017. For comparison, 2...
International guidelines are ambivalent regarding the recommendations for management of clinical stage 1 (CS1) seminoma.During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered regard to assessing modality (radiotherapy, carboplatin, surveillance). Associations tumor size, rete testis invasion, age, year diagnosis, type institution, and geographic location assessed.Of total number patients, 49.3% received carboplatin course, 8.5% 2 courses, 35.9% surveillance, 6.3%...
About 3 – 5% of all patients with testicular germ cell tumour (GCT) develop a contralateral cancer, the majority which arise within 10–15 years. Little is known about risk second GCTs after more than two decades. Here we present cases very late presenting GCT and provide summary similar reported previously. (1) This white Caucasian man underwent right-sided orchiectomy for nonseminomatous at age 22 Additional treatment consisted retroperitoneal lymph node dissection (RPLND) chemotherapy 4...
We evaluated the success rate of continent vesicostomy using an ileal segment with seroserosally embedded, tapered ileum for bladder augmentation stoma following neck closure (BNC) severely damaged bladders or persistent urinary incontinence.