A5055093180- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Hernia repair and management
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Tissue Engineering and Regenerative Medicine
- Prostate Cancer Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Corneal Surgery and Treatments
- Urologic and reproductive health conditions
- Reconstructive Surgery and Microvascular Techniques
- Fibroblast Growth Factor Research
- Ureteral procedures and complications
- Anorectal Disease Treatments and Outcomes
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Wound Healing and Treatments
- Surgical site infection prevention
- Adrenal and Paraganglionic Tumors
- Colorectal Cancer Screening and Detection
- Cardiac tumors and thrombi
Klinikum Rheine
2022-2025
Lukaskrankenhaus
2013-2024
University of Szeged
2018
Klinikum Oldenburg
2016
Heinrich Heine University Düsseldorf
2009-2012
Düsseldorf University Hospital
2012
PharmacoGenetics (China)
2011
The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types cancers, with controversial findings meningiomas. We performed direct sodium bisulfite sequencing a series 50 meningiomas, including 27 benign meningiomas [World Health Organization (WHO) grade I], 11 atypical (WHO II) and 12 anaplastic III), found hypermethylation TIMP3 67% but only 22% 17% Moreover, scores were significantly inversely...
691 Background: Patients with muscle invasive urothelial carcinoma (MIBC) achieving pathological complete response (pCR) upon neoadjuvant chemotherapy (NACT) have improved prognosis. Previously we did show that luminal tumors respond better to NACT (Ecke et al 2022), while chemoresistant express radioligand targets CXCR4 and FAP. First-in-Human treatment of resistant T4 MIBC using two cycles Lu 177 FAP combined one cycle pembrolizumab results in durable (Baum al, submitted). The objective...
Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing antituberculosis drugs and bladder cancer epidemiology. In this study we compared a recently published tagging single nucleotide polymorphism (SNP) (rs1495741) to the conventional 7-SNP genotype (G191A, C282T, T341C, C481T, G590A, A803G G857A haplotype pairs) systematically analysed if novel SNP combinations outperform latter. For purpose, studied 3177 individuals by PCR phenotyped 344 caffeine test....
UBC ® Rapid Test is a test that detects fragments of cytokeratins 8 and 18 in urine. We present results multicentre study measuring bladder cancer patients healthy controls with focus on carcinoma situ (CIS) high-grade cancer. From our N = 452 patients, we made stratified sub-analysis for the urinary bladder. Clinical urine samples were used from 87 tumours (23 situ, 23 non-muscle-invasive low-grade tumours, 21 20 muscle-invasive tumours) 22 controls. The cut-off value was defined at 10.0...
To investigate and relate the ultrashort-term long-term courses of determinants for foreign body reaction as biocompatibility predictors meshes in an animal model.Three different (TVT, UltraPro, PVDF) were implanted sheep. Native plasma coated placed bilaterally: (a) interaperitoneally, (b) fascia onlay, (c) muscle onlay (fascia sublay). At 5 min, 20 60 120 min explanted histochemically investigated inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion,...
Complex vesico-vaginal fistula (VVF) has a high recurrence rate and so the repair with graft tissues seems to be favorable. Amniotic membrane (AM) plays an increasing role as scaffold for of defect tissue due its unique biological properties regard promoting wound healing.An innovative surgical procedure AM-assisted complex Idea Stage following IDEAL recommendations is presented. The development amnion preparation involved steps are described.We able report successful VVF by abdominal...
Objectives: UBC® Rapid Test measures soluble fragments of cytokeratins 8 and 18 in urine. We present results a multicenter study using an updated version bladder cancer patients, patients with urinary positive history, healthy controls. Material Methods: In total 530 urine samples have been included this study. Clinical were used from 242 tumors the (134 non-muscle-invasive low-grade (NMI-LG), 48 high-grade (NMI-HG), 60 muscle-invasive (MI-HG)), 62 non-evidence disease (NED), 226 Urine...
Optimized biocompatibility is a major requirement for alloplastic materials currently applied stress urinary incontinence (SUI) and pelvic organ prolapse (POP) repair. In the preliminary studies mesh modification by coating with autologous plasma resulted in increased adherence score vitro improved an animal model. The first use of coated meshes human presented.Between 04/2013 05/2014, 20 patients indication SUI POP repair were selected single institution. modified prior to implantation. A...
Background: Human amniotic membranes (HAMs) are assumed to have a number of unique characteristics including durability, hypoallergenic and anti-inflammatory properties.Materials Methods: Multilayer HAMs from caesarian sections were applied repair defined bladder defects in male Sprague-Dawley rats.The animals sacrificed at 7, 21 42 days after implantation.Bladder volume capacity grafting was measured.Histological analyses performed asses parameters HAM degradation, inflammatory reaction,...
Objectives To compare Uromonitor® (U‐Monitor Lda, Porto, Portugal), a multitarget DNA assay that detects mutated proto‐oncogenes (telomerase reverse transcriptase [ TERT ], fibroblast growth factor receptor 3 FGFR‐3 Kirsten rat sarcoma viral oncogene homologue KRAS ]), with urine cytology in the urine‐based diagnosis of urothelial carcinoma bladder (UCB) within multicentre real‐world setting. Patients and Methods This multicentre, prospective, double‐blind study was conducted across four...
To compare earlier and later patient groups with Fournier's gangrene, specifically the incidence of rising antibiotic resistance rates in mind. Primary endpoints were to therapy, outcomes, rates.A multicentric, retrospective, multi-national study was performed. Two different time frames treatment defined: Group 1 (n = 50) 2 104). Demographics outcomes analysed using Student-t test, chi-square or Fisher exact test. Survival data estimated Kaplan Meier method compared by Log rank testing.There...
Purpose . To investigate mesh coating modalities with autologous blood components in a recently developed vitro test system for biocompatibility assessment of alloplastic materials. Materials and Methods Seven different types, currently used various indications, were randomly investigated. Meshes coated prior to cultivation peripheral mononuclear cells (PBMCs), platelets, plasma. Pretreated meshes incubated over 6 weeks minced tissue assay, representative fibroblasts, muscle cells,...
Transurethral resection of the prostate is one most frequent urological procedures. Urinary tract infections represent major sequelae, but data about antibiotic prophylaxis in TUR-P are controversial and outdated.We conducted a retrospective multicentre study ten German hospitals. Primary endpoints were epidemiological outcome TUR-P. Secondary identification factors associated with febrile UTIs sepsis after TUR-P.We included 444 patients median age 71.0 years. Nearly every patient (93.5%)...
Infected wounds are difficult to treat and there no standardized protocols. We report a case of infected postoperative wound entero-cutaneous fistula in 83 years-old woman. An innovative treatment protocol for Human amniotic membrane (HAM)-assisted dressing as the Idea Stage following IDEAL recommendations is presented. The development amnion preparation involved steps described. No adverse events graft rejection have been detected. Favorable results confirm technical simplicity, safety...
Functional magnetic resonance imaging (MRI) seems to be a useful tool for prostate cancer (PCa) detection in patients with previous negative biopsy but persistently increased prostate-specific antigen (PSA) values. Additionally, it enables correct localization known PCa under active surveillance avoid misclassification on repeat biopsies. Nevertheless, suspicious lesions MRI findings need verification by biopsy. The aim of the present study was establish standardized functional reporting...