A5036644187- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Inflammatory Biomarkers in Disease Prognosis
- Metastasis and carcinoma case studies
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Soil and Water Nutrient Dynamics
- Cancer Genomics and Diagnostics
- Urinary Tract Infections Management
- Peatlands and Wetlands Ecology
- Ecology and biodiversity studies
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Lipoproteins and Cardiovascular Health
Charité - Universitätsmedizin Berlin
2018-2025
Freie Universität Berlin
2018-2025
Humboldt-Universität zu Berlin
2018-2025
Medical University of Vienna
2013-2020
Vienna General Hospital
2013-2016
Comprehensive Cancer Center Vienna
2014-2015
University of California, Los Angeles
2013
BOKU University
2006
Bundesamt für Wasserwirtschaft
2005
Background Clinically significant prostate cancer (PCa) diagnosis at MRI requires accurate and efficient radiologic interpretation. Although artificial intelligence may assist in this task, lack of transparency has limited clinical translation. Purpose To develop an explainable (XAI) model for clinically PCa biparametric using Prostate Imaging Reporting Data System (PI-RADS) features classification justification. Materials Methods This retrospective study included consecutive patients with...
No AccessJournal of UrologyAdult Urology1 Dec 2013Prognostic Impact Preoperative Neutrophil-to-Lymphocyte Ratio in Localized Nonclear Cell Renal Carcinoma Michela de Martino, Allan J. Pantuck, Sebastian Hofbauer, Matthias Waldert, Shahrokh F. Shariat, Arie S. Belldegrun, and Tobias Klatte MartinoMichela Martino , PantuckAllan Pantuck HofbauerSebastian Hofbauer WaldertMatthias Waldert ShariatShahrokh Shariat BelldegrunArie Belldegrun KlatteTobias View All Author...
Gamma-glutamyltransferase (GGT) regulates apoptotic balance and promotes cancer progression invasion. Higher pretherapeutic GGT serum levels have been associated with worse outcomes in various malignancies, but there are no data for renal cell carcinoma (RCC).Pretherapeutic clinicopathological parameters were retrospectively evaluated 921 consecutive RCC patients treated nephrectomy at a single institution between 1998 2013. was analysed as continuous categorical variable. Associations...
The second version of the PI-RADS™ (Prostate Imaging Reporting and Data System) was introduced in 2015 to standardize interpretation reporting prostate multiparametric magnetic resonance imaging. Recently low cancer detection rates were reported for PI-RADS 2 category 4 lesions. Therefore aim study evaluate rate a large prospective cohort.The included 704 consecutive men with primary or prior negative biopsies who underwent imaging/ultrasound fusion guided targeted biopsy 10-core systematic...
To assess the prognostic role of preoperative serum cholesterol in patients with renal cell carcinoma (RCC), as increasing evidence suggests that alterations lipid profile are associated development, progression and prognosis various cancers.We analysed 867 patients, who underwent radical or partial nephrectomy for RCC between 2002 2012. Preoperative total levels were determined using colorimetric analysis (CHOD-PAP method). The association cancer-specific survival (CSS) was assessed Cox...
Atherosclerosis is considered to be an inflammatory disease in which monocytes and monocyte-derived macrophages play a key role. Circulating can divided into three distinct subtypes, namely classical (CM; CD14++CD16-), intermediate (IM; CD14++CD16+) non-classical (NCM; CD14+CD16++). Low density lipoprotein particles are heterogeneous size density, with small, dense LDL (sdLDL) crucially implicated atherogenesis. The aim of this study was examine whether monocyte subsets associated sdLDL...
•Lipoprotein(a) serves as an independent risk factor in atherosclerotic disease.•Monocyte subsets exhibit distinct inflammatory and atherogenic properties.•Patients with elevated levels of Lp(a) show a shift towards intermediate monocytes.•This association was clinical properties markers.•Those patients also exhibited higher OxPL/apoB concentrations. BackgroundLipoprotein(a) (Lp(a)) is proatherogenic plasma lipoprotein currently established for the development disease predictor acute...
Quantity and the spatial relationship of specific immune cell types can provide prognostic information in bladder cancer. The objective study was to characterize interplay role different subpopulations
We aimed to assess the impact of GATA3 binding protein (GATA3) gene copy number alterations on tumor aggressiveness, patient prognosis, and expression in a large urothelial bladder cancer cohort. A tissue microarray containing over 2,700 cancers (pTa-pT4) was analyzed retrospectively using dual-labeling fluorescence in-situ hybridization (FISH) with probes for (10p14) centromere 10. gains were categorized as elevation (ratio GATA3/centromere ≥ 2/≤4), low-level amplification > 4/≤12),...
// Jino Park 1 , Michaela Schlederer 2,12 Martin Schreiber 3 Ryan Ice 4,5 Olaf Merkel 6 Bilban 7 Sebastian Hofbauer Soojin Kim Joseph Addison Jie Zou 8 Chunyan Ji Silvia T. Bunting 9 Zhengqi Wang Menachem Shoham 10 Gang Huang 11 Zsuzsanna Bago-Horvath 12 Laura F. Gibson 4 Yon Rojanasakul 4,13 Scot Remick Alexey Ivanov Elena Pugacheva Kevin D. Richard Moriggl 2,14 Lukas Kenner 2,12,15,* and William Tse 1,* James Graham Brown Cancer Center, Division of Blood Bone Marrow Transplantation,...
Objective To examine the performance of a primary magnetic resonance imaging ( MRI )/ultrasonography US ) fusion‐guided targeted biopsy TB ), and in combination with an added systematic SB ). Patients Methods Analysis 318 consecutive biopsy‐naïve men suspicious multiparametric (mp ; Prostate Imaging Reporting Data System [ PI ‐ RADS ] score ≥3) undergoing transrectal 10‐core between January 2012 December 2016. The indication for performing mp was based on clinical parameters decided by...
Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of human and plays a key role in telomere restitution gene regulation. Evidence suggests that hTERT linked with risk progression several malignancies, but there are no comprehensive data renal cell carcinoma (RCC). In this case-control study, we assessed seven polymorphic variants (MNS16A, rs2736100, rs2736098, rs7726159, rs2853677, rs13172201, rs10069690), serum levels, length 663 individuals, including 243 clear RCC...
The transcription factor GATA binding protein 3 (GATA3) is commonly used in surgical pathology as a diagnostic marker to distinguish urothelial carcinomas from other cancer entities. However, the clinical relevance of GATA3 expression bladder not completely clarified. In this study, we investigated immunostaining on 2710 tissue microarray platform by using two different antibodies better understand its impact relation pathological parameters disease progression and patient outcome. Nuclear...
Abstract Background Loss of chromosome Y (LOY) has recently been proposed to be associated with cancer aggressiveness, altered T-cell function, and poor prognosis in bladder carcinomas. Methods Chromosome was analyzed using fluorescence in-situ hybridization on a tissue microarray containing 2,071 urothelial carcinomas the urinary from male patients, including 487 patients who had undergone cystectomy for muscle-invasive disease whom follow-up data were available. Data tumor microenvironment...
To evaluate the effect of adjuvant chemotherapy (AC) on mortality after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) with positive lymph nodes (LNs) and to identify patient subgroups that are most likely benefit from AC.We retrospectively analysed data 263 patients LN-positive UTUC, who underwent full surgical resection. In all, 107 (41%) received three six cycles AC, while 156 (59.3%) were treated RNU alone. UTUC-related was evaluated using competing-risks...
To compare the efficacy of multiparametric magnetic resonance imaging (mpMRI)-directed and micro-ultrasonography (micro-US)-directed biopsy for detecting clinically significant (Grade Group >1) prostate cancer (csPCa).A total 203 patients were prospectively enrolled at three institutions across Germany Austria in period from January 2019 to December 2019. During each biopsy, urologist was blinded mpMRI report until after micro-US targets had been assessed. After unblinding, then sampled...