A5103183746- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Virology and Viral Diseases
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Neurofibromatosis and Schwannoma Cases
- Viral Infections and Vectors
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
University Hospital Regensburg
2016-2025
Brain (Germany)
2025
University of Regensburg
2019-2022
Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
2021
Heinrich Heine University Düsseldorf
2004-2011
Ruhr University Bochum
2010
Universitätsklinikum Knappschaftskrankenhaus Bochum
2010
Weatherford College
2008
Massachusetts General Hospital
2005
Harvard University
2005
The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy.From 2001-2011, 87 patients received chemotherapy methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After radiotherapy introduced nonresponders classic (CMB) large-cell/anaplastic (LCA). DNA methylation profiles infantile...
Abstract Background The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) intracranial lesions and evaluation by a neuropathologist with routine frozen section (FS) assessment neuropathology. Methods In phase II noninferiority, prospective, multicenter, nonrandomized, off-label (EudraCT: 2019-004512-58), patients above the age 18 years any lesion scheduled for elective resection were included. diagnostic accuracies both CLE FS...
Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo vitro. In contrast, proneural CSCs resisted due to TGFR2 deficiency. vivo, a substantially increased immune was observed GBMs, while infiltrates were rare GBMs. On functional level, CSC lines caused significantly stronger...
Differentiated neurons established via iPSCs from patients that suffer familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In larger cohort with sporadic PD, iPSC based information on specific cellular phenotypes is rare. We asked whether differences may be present genomic and epigenomic levels performed a comprehensive transcriptomic analysis fibroblasts, differentiated neuronal cells PD-patients controls. found mRNA level, although fibroblasts...
Abstract Mutations and activation of the PI3K signaling pathway in breast cancer cells have been linked to brain metastases. However, here we describe that some metastases samples protein expression components is restricted metastatic microenvironment. In contrast therapeutic effects inhibition on cells, reaction microenvironment less understood. Therefore aimed quantify activity metastasis investigate central nervous system (CNS) First, systematically metastases, performed a prospective...
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis six brain autopsies, we provide first systematic overview on BoDV-1 tissue distribution lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While composition...
Abstract Neuroinflammation and oligodendroglial cytoplasmic α‐synuclein (α‐syn) inclusions (GCIs) are important neuropathological characteristics of multiple system atrophy (MSA). GCIs known to interfere with maturation consequently result in myelin loss. The neuroinflammatory phenotype the context MSA, however, remains poorly understood. Here, we demonstrate MSA‐associated neuroinflammation being restricted myeloid cells tightly linked α‐syncleinopathy. In human putaminal post‐mortem tissue...
More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study ("BoDV-1 after solid-organ transplantation") assess whether there are undetected oligo- or asymptomatic courses infection. A total 216 healthy blood donors and 280 outpatients solid organ transplantation were screened a recombinant BoDV-1 ELISA followed indirect...
Abstract Biallelic loss of SPG11 function constitutes the most frequent cause complicated autosomal recessive hereditary spastic paraplegia (HSP) with thin corpus callosum, resulting in progressive multisystem neurodegeneration. While impact neuroinflammation is an emerging and potentially treatable aspect neurodegenerative diseases leukodystrophies, role immune cells SPG11–HSP patients unknown. Here, we performed a comprehensive immunological characterization SPG11–HSP, including...
The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types cancers, with controversial findings meningiomas. We performed direct sodium bisulfite sequencing a series 50 meningiomas, including 27 benign meningiomas [World Health Organization (WHO) grade I], 11 atypical (WHO II) and 12 anaplastic III), found hypermethylation TIMP3 67% but only 22% 17% Moreover, scores were significantly inversely...
Treatment of glioblastoma (GBM) consists microsurgical resection followed by concomitant radiochemotherapy and adjuvant chemotherapy. The best outcome regarding progression free (PFS) overall survival (OS) is achieved maximal resection. foundation a specialized neuro-oncology care center (NOC) has enabled the implementation large technical portfolio including functional imaging, awake craniotomy, PET scanning, fluorescence-guided resection, integrated postsurgical therapy. This study...
Choroid plexus tumors (CPTs) are intraventricular brain predominantly arising in children but also affecting adults. In most cases, driver mutations have not been identified, although there reports of frequent chromosome-wide copy-number alterations and TP53 mutations, especially choroid carcinomas (CPCs).DNA methylation profiling RNA-sequencing was performed a series 47 CPTs. Samples comprised 35 papillomas (CPPs), 6 atypical (aCPPs) CPCs plus three recurrences thereof. Targeted TERT...
Abstract In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult pediatric differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 by sequencing DNA methylation profiling. Histologically, the series was dominated meningioma subtypes with aggressive behavior, 70% patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18...
Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of BoDV-1 infection diagnosed on day 12 after hospitalization by detection RNA the cerebrospinal fluid. In retrospective analysis, detect hospital admission when cell count fluid is still normal. We develop new ELISA using recombinant nucleoprotein, phosphoprotein, and accessory protein X to seroconversion 12. Antibody...
According to the World Health Organization classification for tumors of central nervous system, mutation status isocitrate dehydrogenase (IDH) genes has become a major diagnostic discriminator gliomas. Therefore, imaging-based prediction IDH is high interest individual patient management. We compared and evaluated value radiomics derived from dual positron emission tomography (PET) magnetic resonance imaging (MRI) data predict non-invasively.