A5086284631- Glioma Diagnosis and Treatment
- Neural dynamics and brain function
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Radiopharmaceutical Chemistry and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Medical Malpractice and Liability Issues
- Traumatic Brain Injury and Neurovascular Disturbances
- Cervical and Thoracic Myelopathy
- Medical Imaging Techniques and Applications
- Patient Safety and Medication Errors
- Cell Image Analysis Techniques
- Brain Tumor Detection and Classification
- Musculoskeletal pain and rehabilitation
- MRI in cancer diagnosis
- Medical Imaging and Pathology Studies
Universität Hamburg
2022-2025
Klinikum rechts der Isar
2016-2025
Technical University of Munich
2015-2025
University Medical Center Hamburg-Eppendorf
2022-2025
Committee on Publication Ethics
2022
University Hospital Leipzig
2020
Max Planck Florida Institute for Neuroscience
2011-2017
Max Planck Institute for Medical Research
2009-2015
Max Planck Society
2010
Soma location, dendrite morphology, and synaptic innervation may represent key determinants of functional responses individual neurons, such as sensory-evoked spiking. Here, we reconstruct the 3D circuits formed by thalamocortical afferents from lemniscal pathway excitatory neurons an anatomically defined cortical column in rat vibrissal cortex. We objectively classify 9 cell types estimate number distribution their somata, dendrites, synapses. Somata dendrites most intermingle, while...
Although physiological data on microcircuits involving a few inhibitory neurons in the mammalian cerebral cortex are available, quantitative relation between inhibition and excitation cortical circuits thousands of largely missing. Because distribution is very inhomogeneous cortex, it critical to map all given volume rather than rely sparse sampling methods. Here, we report comprehensive mapping interneurons (INs) columns rat somatosensory immunolabeled for neuron-specific nuclear protein...
The human cerebral cortex houses 1000 times more neurons than that of the a mouse, but possible differences in synaptic circuits between these species are still poorly understood. We used three-dimensional electron microscopy macaque, and cortical samples to study their cell type composition circuit architecture. 2.5-fold increase interneurons humans compared with mice was compensated by change axonal connection probabilities therefore did not yield commensurate inhibitory-versus-excitatory...
This is the concluding article in a series of 3 studies that investigate anatomical determinants thalamocortical (TC) input to excitatory neurons cortical column rat primary somatosensory cortex (S1). We used viral synaptophysin-enhanced green fluorescent protein expression thalamic and reconstructions biocytin-labeled TC slices quantify number distribution boutons from ventral posterior medial (VPM) posteromedial (POm) nuclei potentially innervating dendritic arbors located layers (L)2–6...
To understand sensory representation in cortex, it is crucial to identify its constituent cellular components based on cell-type–specific criteria. With the identification of cell types, an important question can be addressed: what degree does properties neurons depend cortical location? We tested this using pyramidal layer 5 (L5) because their role providing major output subcortical targets. Recently developed transgenic mice with enhanced green fluorescent protein labeling neuronal...
This is the second article in a series of three studies that investigate anatomical determinants thalamocortical (TC) input to excitatory neurons cortical column rat primary somatosensory cortex (S1). Here, we report number and distribution NeuN-positive within C2, D2, D3 TC projection columns P27 barrel based on an exhaustive identification 89 834 somata 1.15 mm3 volume cortex. A single contained 19 109 ± 444 (17 560 399 when normalized standard-size column). Neuron density differences...
Abstract Background The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) intracranial lesions and evaluation by a neuropathologist with routine frozen section (FS) assessment neuropathology. Methods In phase II noninferiority, prospective, multicenter, nonrandomized, off-label (EudraCT: 2019-004512-58), patients above the age 18 years any lesion scheduled for elective resection were included. diagnostic accuracies both CLE FS...
Significance Cortical columns are thought to be the elementary functional building blocks of sensory cortices. Here we show that cellular architecture cortical “barrel” in rodent somatosensory cortex is not stereotypic, but specific for each whisker on animals’ snout. Our findings challenge concepts underlying contemporary simulation efforts build up large-scale network models repeatedly occurring identical circuits.
Spinal metastases at the thoracolumbar junction (TLJ) pose a significant risk for spinal instability and necessitate special considerations regarding surgical management. Longer patient survival due to improved oncologic therapies may justify extensive instrumented surgery. The aim of this study was analyze standard care in large multicentric cohort patients with TLJ decision-making, management, associated morbidity. Patients surgically treated between 2010 2022 were enrolled five academic...
The discovery of cellular tumor networks in glioblastoma, with routes malignant communication extending far beyond the detectable margins, has highlighted potential supramarginal resection strategies. Retrospective data suggest that these approaches may improve long-term disease control. However, their application is limited by proximity critical brain regions and vasculature, posing challenges for validation randomized trials. Anterior temporal lobectomy (ATL) a standardized surgical...
<h3>BACKGROUND AND PURPOSE:</h3> Cerebral vasospasm remains a strong predictor of poor outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Endovascular treatment can be considered when conservative options are exhausted, but its superiority over standard subject critical debate. This study focuses on patients with clinically relevant aSAH who underwent endovascular and aims to analyze patients' individual risk factors, intensity, extent cerebral associated functional aSAH....
Background: Patients with metastatic spinal cord compression (MSCC) may experience long-term functional impairment. It has been established that surgical decompression improves neurological outcomes, but the effect of early surgery remains uncertain. Our objective was to evaluate impact versus late for acute MSCC due metastases (SM). Methods: We retrospectively reviewed a consecutive cohort all patients undergoing SMs at our institution. determined prevalence MSCC; time between deterioration...
Background: Resection followed by local radiation therapy (RT) is the standard of care for symptomatic brain metastases. However, optimal technique, fractionation scheme and dose are still being debated. Lately, low-energy X-ray intraoperative RT (lex-IORT) has been increasing interest. Method: Eighteen consecutive patients undergoing BM resection immediate lex-IORT with 16–30 Gy applied to spherical applicator were retrospectively analyzed. Demographic, RT-specific, radiographic clinical...
<h3>BACKGROUND AND PURPOSE:</h3> Cerebral vasospasm is a common complication of aneurysmal SAH and remains risk factor for delayed cerebral ischemia poor outcome. The interrater reliability CTA in combination with CTP has not been sufficiently studied. We aimed to investigate the alone detection decision initiate endovascular treatment. <h3>MATERIALS METHODS:</h3> This retrospective single-center study including patients treated SAH. Inclusion criteria were baseline follow-up imaging due...
Due to demographic changes and an increased incidence of cancer with age, the number patients brain metastases (BMs) constantly increases, especially among elderly. Novel systemic therapies, such as immunotherapy, have led improved survival in recent years, but intracranial tumor progression may occur independently a systemically effective therapy. Despite growing geriatric patients, they are often overlooked clinical trials, there is no consensus on impact BM resection survival.The aim this...
Stimulation of a principal whisker yields sparse action potential (AP) spiking in layer 2/3 (L2/3) pyramidal neurons cortical column rat barrel cortex. The low AP rates could be explained by activation interneurons L2/3 providing inhibition onto neurons. classified as local inhibitors based on their axonal projection the same were reported to receive strong excitatory input from spiny L4, which are also main source Here, we investigated remaining synaptic connection this intracolumnar...
Adverse events in surgery are a relevant cause of costs, disability, or death, and their incidence is key quality indicator that plays an important role the future health care. In neurosurgery, little known about frequency adverse contribution human error.To determine incidence, nature severity to investigate error.Prospective observation all occurring at academic neurosurgery referral center focusing on neuro-oncology, cerebrovascular spinal surgery. All 4176 inpatients treated between...
Intratumoral heterogeneity at the cellular and molecular level is a hallmark of glioblastoma (GB) that contributes to treatment resistance poor clinical outcome. Little known regarding epigenetic intratumoral phylogeny their implication for classification targeted therapies.
Background: The fifth version of the World Health Organization (WHO) classification tumors central nervous system (CNS) in 2021 brought substantial changes. Driven by enhanced implementation molecular characterization, some diagnoses were adapted while others newly introduced. How these changes are reflected imaging features remains scarcely investigated. Materials and Methods: We retrospectively analyzed 226 treatment-naive primary brain tumor patients from our institution who received...
PURPOSE: To compare the diagnostic value of magnetic resonance (MR) imaging and transesophageal echocardiography (TEE) in follow-up chronic dissection thoracic aorta. MATERIALS AND METHODS: Follow-up MR TEE were performed 25 consecutive patients with aortic dissection. Ten had a type I 15 III All underwent surgical intervention. dissections managed medically, five RESULTS: Identification persisting differentiation true false lumina equal both methods. The arch vessels all anastomoses...