A5062030303- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Management of metastatic bone disease
- Lung Cancer Research Studies
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Vascular Malformations Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Bone health and osteoporosis research
- Cervical and Thoracic Myelopathy
- Intraoperative Neuromonitoring and Anesthetic Effects
- Multiple Myeloma Research and Treatments
- Fetal and Pediatric Neurological Disorders
- Pituitary Gland Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Pelvic and Acetabular Injuries
- Musculoskeletal pain and rehabilitation
- Cancer Genomics and Diagnostics
- Bone and Joint Diseases
- Cardiac tumors and thrombi
Technical University of Munich
2020-2025
Klinikum rechts der Isar
2019-2025
Klinik und Poliklinik für Neurologie
2020
Abstract Background The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) intracranial lesions and evaluation by a neuropathologist with routine frozen section (FS) assessment neuropathology. Methods In phase II noninferiority, prospective, multicenter, nonrandomized, off-label (EudraCT: 2019-004512-58), patients above the age 18 years any lesion scheduled for elective resection were included. diagnostic accuracies both CLE FS...
Objective Decreased bone mineral density (BMD) impairs screw purchase in trabecular and can cause loosening following spinal instrumentation. Existing computed tomography (CT) scans could be used for opportunistic osteoporosis screening decreased BMD. Purpose of this case-control study was to investigate the association opportunistically assessed BMD with outcome after surgery semi-rigid instrumentation lumbar degenerative instability. Methods We reviewed consecutive patients that had...
Background A reduced Karnofsky performance score (KPS) often leads to the discontinuation of surgical and adjuvant therapy, owing a lack evidence survival quality life benefits. This study aimed examine clinical treatment outcomes patients with KPS < 70 after neurosurgical resection identify prognostic factors associated better survival. Methods Patients preoperative who underwent for newly diagnosed brain metastases (BM) between 2007 2020 were retrospectively analyzed. The KPS, age,...
Abstract Purpose To evaluate the accuracy of opportunistic measurements volumetric bone mineral density (vBMD) in intraoperative multi-detector CT (MDCT) scans, using preoperative MDCT as reference. Methods This retrospective, single-center study included 105 patients (mean age: 73 ± 12.6 years, 53 women) who underwent spine surgery for various indications. All had with/without intravenous contrast and unenhanced scans. VBMD thoracolumbar vertebrae was automatically extracted a convolutional...
Abstract Background For recurrent glioblastoma (GB) patients, several therapy options have been established over the last years such as more aggressive surgery, re-irradiation or chemotherapy. Age and Karnofsky Performance Status Scale (KPSS) are used to make decisions for these patients prognostic factors in initial diagnosis of GB. This study’s aim was evaluate preoperative patient comorbidities by using age-adjusted Charlson Comorbidity Index (ACCI) a factor GB patients. Methods In this...
Due to demographic changes and an increased incidence of cancer with age, the number patients brain metastases (BMs) constantly increases, especially among elderly. Novel systemic therapies, such as immunotherapy, have led improved survival in recent years, but intracranial tumor progression may occur independently a systemically effective therapy. Despite growing geriatric patients, they are often overlooked clinical trials, there is no consensus on impact BM resection survival.The aim this...
Abstract Background H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. Case presentation We report the case of a 24-year-old man patient multiple, inter alia osseous metastases who presented back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The underwent combined radio-chemotherapy demonstrated temporary improvement before deteriorating. Conclusions glioma presents an infrequent but crucial differential diagnosis should be...
Background: Resection of jugular foramen schwannomas (JFSs) with minimal cranial nerve (CN) injury remains difficult. Reoperations in this vital region are associated severe CN deficits. Methods: We performed a retrospective analysis at tertiary neurosurgical center patients who underwent surgery for JFSs between June 2007 and May 2020. included nine (median age 60 years, 77.8% female, 22.2% male). Preoperative symptoms hearing loss (66.6%), headache (44.4%), hoarseness (33.3%), dysphagia...
(1) Background: As resection of trigeminal schwannomas is challenging, due to anatomical involvement the anterior, middle and posterior fossa, appropriate approach important. We report our experience with surgical by simple classic skull-base approaches. (2) Methods: performed a retrospective single-center study including patients who underwent surgery for schwannoma tumors between June 2007 May 2020, concentrating on technique, extent resection, postoperative outcome complications. (3)...
Intratumoral heterogeneity at the cellular and molecular level is a hallmark of glioblastoma (GB) that contributes to treatment resistance poor clinical outcome. Little known regarding epigenetic intratumoral phylogeny their implication for classification targeted therapies.
Brain metastases were considered to be well-defined lesions, but recent research points infiltrating behavior. Impact of postoperative residual tumor burden (RTB) and extent resection are still not defined enough.Adult patients with surgery brain between April 2007 January 2020 analyzed. Early MRI (<72 h) was used segment RTB. Survival analysis performed cutoff values for RTB revealed. Separate (subgroup) analyses regarding radiotherapy, age, histopathological entities performed.A total 704...
(1) Background: Midline meningiomas such as olfactory groove (OGMs), planum sphenoidale (PSMs), or tuberculum sellae (TSMs) are challenging, and determining the appropriate approach is important. We propose a decision algorithm for choosing suitable transcranial approaches. (2) Methods: A retrospective chart review between 06/2007 01/2020. Clinical outcomes, radiographic findings, postoperative complication rates were analyzed with respect to operative (3) Results: included 88 patients in...
Manifestation of malignant lymphoma in the spine is rare; there have only been a few cases reported literature. Due to its rarity, no gold standard for management patients suffering from spinal manifestations. Methods: We retrospectively reviewed data 37 (14 female, 23 male) with receiving intervention our center March 2006 until June 2020. Neurological impairment, pain, diagnostics, and/or surgical instability were criteria surgery this patient cohort. Otherwise, CT-guided biopsies...
Objective: The management of petroclival meningiomas (PCMs) remains notoriously difficult due to their close association with neurovascular structures and complex anatomy, hence the surgical paradigm change from radical functional resection in past. With this study, we aimed analyze outcomes a modern consecutive series patients PCMs. Methods: We reviewed patient charts imaging data 64 2006 2018 PCM resected at our institution compared between subgroups stratified by approach. Results:...
(1) Background: Surgery for spinal metastases has gained a decisive role in modern oncological treatment. Recently, carbon-fiber-reinforced (CFR) polyethyl-ether-ether-ketone (PEEK) pedicle screw systems were introduced, reducing artifacts on imaging and showing less perturbation effects photon radiation. Preliminary clinical experience with CFR-PEEK implants exists. The aim of this monocentric study is to report the safety efficacy neoplasms large cohort consecutive patients. (2) Methods:...
Opportunistic quantitative computed tomography (oQCT) derived from non-dedicated routine CT has demonstrated high accuracy in diagnosing osteoporosis and predicting incident vertebral fractures (VFs). We aimed to investigate the cost-effectiveness of oQCT screening compared dual-energy X-ray absorptiometry (DXA) as standard care for screening.Three strategies ("no screening", "oQCT "DXA screening") after were simulated a state-transition model hypothetical cohorts 1,000 patients (women men...
Despite advances in treatment for brain metastases (BMs), the prognosis recurrent BMs remains poor and requires further research to advance clinical management improve patient outcomes. In particular, data addressing impact of tumor volume surgical resection with regard survival remain scarce.Adult patients between December 2007 2022 were analyzed. A distinction was made operated non-operated patients, residual burden (RTB) determined by using (postoperative) MRI. Survival analysis performed...
Abstract Background Intraventricular neuroepithelial tumors (IVT) are rare lesions and comprise different pathological entities such as ependymomas, subependymomas central neurocytomas. The treatment of choice is neurosurgical resection, which can be challenging due to their intraventricular location. Different surgical approaches the ventricles described. Here we report a large series IVTs, its postoperative outcome at single tertiary center discuss suitable approaches. Methods We performed...
Median overall survival (OS) after diagnosis of glioblastoma (GBM) remains 15 months amongst patients receiving aggressive surgical resection, chemotherapy and irradiation. Treatment with a poor preoperative Karnofsky Performance Status Scale (KPSS) is still controversial. Therefore, we retrospectively assessed the outcome treatment in KPSS ≤60%.We included de-novo WHO °IV ≤60%, who underwent surgery at two neurosurgical centres between September 2006 March 2016. We recorded pre-...
Background: Graded Prognostic Assessment (GPA) has been proposed for various brain metastases (BMs) tailored to the primary histology and molecular profiles. However, it does not consider whether patients have operated on or include surgical outcomes as prognostic factors. The residual tumor burden (RTB) is a strong predictor of overall survival. We validated GPA score introduced “volumetric GPA” in largest cohort further explored role RTB an additional factor. Methods: A total 630 with BMs...
Accessing the posterior base of skull is complex because vital neurovascular structures in area. However, retrosigmoid approach (RSA) offers a solution to this challenge. To analyze surgical outcome RSA. This study involved retrospective review patient charts from single center, focusing on procedure and outcomes following operation. The included 517 patients suffering conditions like vestibular schwannomas (VS), metastatic cancers, trigeminal neuralgia. most frequent symptoms reported were...
Intraoperative magnetic resonance imaging (iMRI) has witnessed significant growth in the field of neurosurgery, particularly glioma surgery, enhancing image-guided neuronavigation and optimizing extent resection (EOR). Despite its extensive use treatment gliomas, utility brain metastases (BMs) remains unexplored. This study examined effect iMRI on BM resection. retrospective was conducted at neurosurgical center University Hospital Technical Munich involved 25 patients with who underwent...
Abstract We aimed to identify independent psychological predictors of quality life (QOL) and functional outcome after anterior cervical discectomy fusion (ACDF) for degenerative spine disease. prospectively included patients undergoing ACDF disc herniation stenosis. Patients completed a structured assessment including the Center Epidemiological Studies Depression Scale (ADS-K), Post-Traumatic Stress Scale-10 (PTSS-10), State Trait Anxiety Inventory-State - (STAI-S STAI-T) Sensitivity Index-3...