A5033667315- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Management of metastatic bone disease
- Lung Cancer Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Radiopharmaceutical Chemistry and Applications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cerebrospinal fluid and hydrocephalus
- Neurofibromatosis and Schwannoma Cases
- Cerebral Venous Sinus Thrombosis
- Potassium and Related Disorders
- Amino Acid Enzymes and Metabolism
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Aortic aneurysm repair treatments
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Iron Metabolism and Disorders
- Vestibular and auditory disorders
Universität Hamburg
2023-2024
Klinikum rechts der Isar
2021-2024
Technical University of Munich
2021-2024
University Medical Center Hamburg-Eppendorf
2023-2024
University of Bari Aldo Moro
2019
The University of Sydney
2019
Abstract Background The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) intracranial lesions and evaluation by a neuropathologist with routine frozen section (FS) assessment neuropathology. Methods In phase II noninferiority, prospective, multicenter, nonrandomized, off-label (EudraCT: 2019-004512-58), patients above the age 18 years any lesion scheduled for elective resection were included. diagnostic accuracies both CLE FS...
Background A reduced Karnofsky performance score (KPS) often leads to the discontinuation of surgical and adjuvant therapy, owing a lack evidence survival quality life benefits. This study aimed examine clinical treatment outcomes patients with KPS < 70 after neurosurgical resection identify prognostic factors associated better survival. Methods Patients preoperative who underwent for newly diagnosed brain metastases (BM) between 2007 2020 were retrospectively analyzed. The KPS, age,...
Due to demographic changes and an increased incidence of cancer with age, the number patients brain metastases (BMs) constantly increases, especially among elderly. Novel systemic therapies, such as immunotherapy, have led improved survival in recent years, but intracranial tumor progression may occur independently a systemically effective therapy. Despite growing geriatric patients, they are often overlooked clinical trials, there is no consensus on impact BM resection survival.The aim this...
Brain metastases were considered to be well-defined lesions, but recent research points infiltrating behavior. Impact of postoperative residual tumor burden (RTB) and extent resection are still not defined enough.Adult patients with surgery brain between April 2007 January 2020 analyzed. Early MRI (<72 h) was used segment RTB. Survival analysis performed cutoff values for RTB revealed. Separate (subgroup) analyses regarding radiotherapy, age, histopathological entities performed.A total 704...
Background: Graded Prognostic Assessment (GPA) has been proposed for various brain metastases (BMs) tailored to the primary histology and molecular profiles. However, it does not consider whether patients have operated on or include surgical outcomes as prognostic factors. The residual tumor burden (RTB) is a strong predictor of overall survival. We validated GPA score introduced “volumetric GPA” in largest cohort further explored role RTB an additional factor. Methods: A total 630 with BMs...
Malignant swelling is a fatal complication that can occur abruptly in space-occupying cerebellar infarction. We aimed to establish markers predict malignant
Abstract Purpose Multiple solutions for navigation-guided pedicle screw placement are available. However, the efficiency with regard to clinical and resource implications has not yet been analyzed. The present study’s aim was analyze whether an operating room sliding gantry CT (ORCT)-based approach spinal instrumentation is more efficient than a mobile cone-beam (CBCT)-based approach. Methods This cohort study included random sample of 853 patients who underwent using ORCT-based or...
Multiple solutions for navigation-guided pedicle screw placement are currently available. Intraoperative imaging techniques invaluable spinal surgery, but often there is little attention paid to patient radiation exposure. This study aimed compare the applied doses of sliding gantry CT (SGCT)- and mobile cone-beam (CBCT)-based instrumentation.The authors retrospectively analyzed 183 54 patients who underwent SGCT- or standard CBCT-based placement, respectively, instrumentation at their...
Abstract TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of and functional 3 months SAH. Data were obtained in frame a randomized controlled trial exploring Goal-directed hemodynamic therapy SAH (NCT01832389). was measured daily for first 14 days admission or until discharge from ICU. Outcome assessed using Glasgow Scale (GOS) discharge. Logistic...
(1) Background: Plasma cell neoplasia can be separated into independent subtypes including multiple myeloma (MM) and solitary plasmacytoma of the bone (SBP). The first clinical signs patients present with are skeletal pain, most commonly involving ribs vertebrae. (2) Methods: Retrospective analysis 114 (38 female, 76 male) receiving spinal surgery from March 2006 until April 2020. Neurological impairments surgical instability were criteria for intervention in this cohort. Analysis was based...
Many patients with high-grade gliomas (HGG) are of older age. We hypothesize that pre- and intraoperative mapping monitoring preserve functional status in elderly while gross total resection (GTR) is the aim, resulting overall survival (OS) rates comparable to general population HGG. subdivided a prospective cohort 168 above 65 years eloquent into four groups ([years/cases] 1: 65–69/58; 2: 70–74/47; 3: 75–79/43; 4: >79/20). All underwent preoperative noninvasive mapping, which was also used...
Background Brain metastases (BM) are a common and challenging issue, with their incidence on the rise due to advancements in systemic therapies increased patient survival. Most patients present single BM, some of them without any further extracranial metastasis (i.e., solitary BM). The significance postoperative intracranial tumor volume treatment singular BM is still debated. Objective This study aimed determine impact resection burden overall survival (OS) BM. Methods Patients surgically...
Introduction: Spinal intradural tumors account for 15% of all CNS tumors. Typical tumor entities include ependymomas, astrocytomas, meningiomas, and neurinomas. In cases multiple affected segments, extensive approaches may be necessary to achieve the gold standard complete resection. Methods: We performed a bicentric, retrospective cohort study patients equal or older than 14 years who underwent multi-segment surgical treatment spinal between 2007 2023 with longer four segments without...
Abstract BACKGROUND Immunotherapy (IT) has gained increased significance as a systemic therapy option in the management of various types metastatic cancer, including cases involving brain metastases (BMs). The differential diagnosis progressive/relapsed BMs and treatment-related changes (TRC) is often based on imaging with amino acid (AA) PET, addition to standard magnetic resonance (MRI), this been established provide higher diagnostic accuracy. However, value AA-PET context IT not studied...
Background and Purpose: Decompressive surgery is a potentially life-saving treatment in patients with malignant space-occupying cerebellar infarction. However, there only limited literature on functional outcomes complications after surgery. Our aim was to establish markers which predict poor outcome. Methods: We retrospectively analyzed data of all who underwent due swelling infarction our hospital between 2005 2023. Statistical analyses were conducted multiple parameters identify...
Abstract BACKGROUND The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) intracranial lesions and evaluation by a neuropathologist with routine frozen section (FS) assessment Neuropathology. METHODS In phase II non-inferiority, prospective, multicenter, non-randomized, off-label (Eudra-CT: 2019-004512-58), patients above the age 18 years any lesion scheduled for elective resection were included. diagnostic accuracies both CLE FS...
Intraoperative neuromonitoring (IOM) of motor/somatosensory evoked potentials is a well-established approach for reducing ischemic complications after aneurysm clipping.To determine the predictive validity IOM postoperative functional outcome and its perceived added value intraoperative real-time feedback impairment in surgical treatment unruptured intracranial aneurysms (UIAs).Prospective study patients scheduled elective clipping UIAs between 02/2019-02/2021. Transcranial motor (tcMEP)...
Immature platelets are newly formed with an increased prothrombotic potential. This study evaluates whether immature associated relevant complications in neurosurgical patients. Data were obtained the frame of a prospectively conducted observational exploring association between and major cardiovascular events after surgery. platelet fraction (IPF) H-IPF (highly fluorescent fraction) measured preoperatively postoperatively at ward (24–72 hours surgery). Therapy-relevant surgery stratified...