A5073895168- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Health Systems, Economic Evaluations, Quality of Life
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Neural dynamics and brain function
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Diet and metabolism studies
- MRI in cancer diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Neural and Behavioral Psychology Studies
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- EEG and Brain-Computer Interfaces
Klinikum rechts der Isar
2016-2025
Technical University of Munich
2016-2025
Ludwig-Maximilians-Universität München
2015-2025
St. Petersburg State Medical Academy "City Polyclinic №44"
2025
Klinik und Poliklinik für Nuklearmedizin
2012-2025
Cancer Research Center
2024
German Center for Neurodegenerative Diseases
2018-2023
Munich Cluster for Systems Neurology
2023
München Klinik
2019-2020
Radiation Oncology Associates
2019
All drugs of abuse induce a phasic dopamine release within the striatum that does not undergo habituation. Prolonged substance consumption impairs natural function mesolimbic system, as shown by decrease in availability striatal 2 (D(2)) receptors patients suffering from cocaine, heroin, amphetamine, and alcohol dependence. However, it is unclear whether similar changes can also be observed heavy-smoking nicotine-dependent smokers.In vivo D(2)/D(3) receptor was determined with [...
White matter alterations are present in the majority of patients with Alzheimer's disease type dementia. However, spatiotemporal pattern white changes preceding dementia symptoms remains unclear, largely due to inherent diagnostic uncertainty preclinical phase and increased risk confounding age-related vascular stroke late-onset disease. In early-onset autosomal-dominantly inherited disease, participants destined develop dementia, which provides opportunity assess brain years before onset...
Based on the hippocampus disconnection hypothesis in Alzheimer disease (AD), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes activity, we suggested patients with AD, more intrinsic functional connectivity between and precuneus is decreased, higher hippocampal glucose metabolism will be.Forty mild AD dementia, 21 cognitive impairment, 26 healthy controls underwent simultaneous PET/MRI measurements an integrated PET/MR scanner....
Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks. However, age-related network changes commonly co-occur with neuropathological cascades, limiting efforts to disentangle disease-specific alterations in function those associated normal ageing. Here we elucidate the differential effects of ageing disease pathology through simultaneous analyses two datasets: (i)...
"Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. Advanced brain-predicted has been well established in symptomatic Alzheimer disease (AD), but is underexplored preclinical AD. Prior studies have typically used structural MRI, resting-state functional connectivity (FC) remains underexplored. Our model predicted from FC 391 cognitively normal, amyloid-negative controls (ages 18-89). We applied the trained 145 amyloid-negative, 151 AD, and 156...
In comparison to other species, the human brain exhibits one of highest energy demands relative body metabolism. It remains unclear whether this heightened demand uniformly supports an enlarged or if specific signaling mechanisms necessitate greater energy. We hypothesized that regional distribution will reveal strategies have contributed cognitive development. measured within functional connectome using multimodal imaging and found pathways in evolutionarily expanded regions up 67% higher...
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons case–control studies. age onset highly predictable within families, allowing researchers to estimate individual’s point the trajectory. These characteristics allow candidate...
Single-subject voxel-based morphometry (VBM) is a powerful technique for reader-independent detection of brain atrophy in structural magnetic resonance imaging (MRI) to support the (differential) diagnosis and staging neurodegenerative diseases individual patients. However, VBM sensitive MRI scanner platform details acquisition sequence. To mitigate this limitation, we recently proposed Clinical validation CNN-based VBM. was compared with conventional based on mixed-scanner normative...
Despite revolutionary efficacy of CD19-CAR-T cell therapy (CAR-T) in aggressive B lymphoma, many patients still relapse mostly early. In early failure, distinct drugs support CAR-T which makes reliable and prediction imminent relapse/refractoriness critical. A complete metabolic remission (CR) on Fluor-18-Deoxyglucose (FDG) Positron-Emission-Computed Tomography (PET) 30 days after (PET30) strongly predicts progression-free survival (PFS), but fails a relevant proportion patients. We aimed to...
<b>Background:</b> Neurologic hallmarks of Fabry disease (FD) include small fiber neuropathy as well cerebral micro- and macroangiopathy with premature stroke. Cranial MRI shows progressive white matter lesions (WML) at an early age, increased signal intensity in the pulvinar, tortuosity dilatation larger vessels. To unravel most promising imaging tool for detection CNS involvement FD we compared diagnostic utility different MR findings. <b>Methods:</b> Twenty-five clinically affected...
Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with <sup>18</sup>F-FDG captures neuronal activity that is steady state at a longer time span and less dependent on neurovascular coupling. <b>Methods:</b> In the present study, we aimed to identify RSNs data compare their spatial pattern those obtained from simultaneously acquired fMRI 22 middle-aged healthy subjects. <b>Results:</b> Thirteen 17 meaningful could be...
Frontotemporal lobar degeneration (FTLD) is a common cause of early onset dementia. Behavioral variant frontotemporal dementia (bvFTD), its most subtype, characterized by deep alterations in behavior and personality. In 2011, new diagnostic criteria were suggested that incorporate imaging into algorithms. The study aimed at validating the potential to individually predict diagnosis with machine learning Brain atrophy was measured structural magnetic resonance (MRI) 3 Tesla multi-centric...
Abstract Background Cerebrospinal fluid (CSF) analysis for detecting amyloid positivity may be as reliable positron emission tomography (PET). We evaluated the performance of beta (Aβ)42/40 ratio predicting by PET, compared with Aβ42 alone, and phosphorylated tau 181 (pTau181)/Aβ42 total (tTau)/Aβ42 ratios, using fully automated CSF immunoassays (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) in a heterogeneous cohort patients range cognitive disorders reflecting typical...
Summary: Purpose: Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing. Methods: To quantify D2/D3‐receptor density, we studied seven patients with temporal lobe (TLE) and nine age‐matched controls positron emission tomography (PET) by using high‐affinity dopamine ligand [ 18 F]Fallypride ([ F]FP) suitable imaging binding. TLE was defined interictal ictal video‐EEG, magnetic resonance (MRI),...