A5006832105- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Health, Environment, Cognitive Aging
- S100 Proteins and Annexins
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Schizophrenia research and treatment
- Bioinformatics and Genomic Networks
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Brain Tumor Detection and Classification
- Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Genetic Neurodegenerative Diseases
Fundacion Centro De Investigacion De Enfermedades Neurologicas
2023-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2009-2025
Instituto de Salud Carlos III
2021-2025
University of Gothenburg
2020-2025
Centro de Investigación Biomédica en Red
2021-2025
German Center for Neurodegenerative Diseases
2015-2024
Hospital Universitario Virgen del Rocío
2020-2024
Instituto de Biomedicina de Sevilla
2020-2024
Universidad de Sevilla
2020-2024
Landscape Research Group
2023
To estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging an individual's pathology.
Plasma phosphorylated tau at threonine 181 (p-tau181) has been proposed as an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its ability to monitor progression in AD remains unclear.To study potential longitudinal plasma p-tau181 measures assessing neurodegeneration and cognitive decline comparison neurofilament light chain (NfL), a disease-nonspecific marker neuronal injury.This cohort included data from Alzheimer's Disease Neuroimaging Initiative...
Histopathological studies in Alzheimer's disease (AD) suggest severe and region-specific neurodegeneration of the basal forebrain cholinergic system (BFCS). Here, we studied between-center reliability diagnostic accuracy MRI-based BFCS volumetry a large multicenter data set, including participants with prodromal (n = 41) or clinically manifest AD 134) 148 cognitively healthy controls. Atrophy was determined using voxel-based region-of-interest based analyses high-dimensionally normalized MRI...
Abstract Tau phosphorylated at threonine 181 (p-tau181) measured in blood plasma has recently been proposed as an accessible, scalable, and highly specific biomarker for Alzheimer’s disease. Longitudinal studies, however, investigating the temporal dynamics of this novel are lacking. It is therefore unclear when disease process p-tau181 increases above physiological levels how it relates to spatiotemporal progression characteristic pathologies. We aimed establish natural time course across...
See Gratwicke and Foltynie (doi:10.1093/brain/awx333) for a scientific commentary on this article.Cognitive impairments are prevalent disabling non-motor complication of Parkinson's disease, but with variable expression progression. The onset serious cognitive decline occurs alongside substantial cholinergic denervation, imprecision previously available techniques in vivo measurement degeneration limit their use as predictive biomarkers. However, recent developments stereotactic mapping the...
Abstract The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains differential interaction with diverse brain systems. We show location human tissue samples extracted adult can be predicted within 2mm using expression pattern less than 100 genes. Futhermore, this model generalizes to an external set from prenatal hippocampi. examine variation in specific gene across whole brain, finding distinct anterioventral-posteriodorsal...
Abstract An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested staging and nomenclature have proven useful autopsy practice dementia research. However, some issues remain unresolved, such as cases with unusual features that do not fit current diagnostic categories. goal of this is to update the criteria diagnosis LATE-NC, based primarily on published data. We...
Neuropathological studies suggest that the basal forebrain cholinergic system (BFCS) is affected in Alzheimer's disease (AD), but there no vivo evidence of early damage to this subjects at high risk developing AD. Here, we found mild cognitive impairment (MCI) patients exhibited significant volume reduction nucleus basalis Meynert (NbM) using recently developed probabilistic maps BFCS space. In addition, volumes different magnocellular compartments varied significantly with regional gray...
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of hippocampus on MR. The aim this study is to concurrent validity HarP toward local protocols, and its major sources variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T 3T following qualified based through standard web‐platform resegmented HarP. five most accurate followed segment 15 ADNI acquired three...
Abstract Alzheimer's disease (AD) patients exhibit alterations in the functional connectivity between spatially segregated brain regions which may be related to both local gray matter (GM) atrophy as well a decline fiber integrity of underlying white tracts. Machine learning algorithms are able automatically detect patterns image data, and therefore, constitute suitable basis for automated diagnostic systems. The question magnetic resonance imaging (MRI) modalities most useful clinical...
Brain tissue changes in autism spectrum disorders seem to be rather subtle and widespread than anatomically distinct. Therefore a multimodal, whole brain imaging technique appears an appropriate approach investigate whether alterations white gray matter integrity relate consistent functional resting state connectivity individuals with high functioning (HFA). We applied diffusion tensor (DTI), voxel-based morphometry (VBM) magnetic resonance (fcMRI) assess differences structure function...
Few studies have investigated in vivo changes of the cholinergic basal forebrain Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI), an at risk stage AD. Even less is known about alterations cortical projecting fiber tracts associated with atrophy. In this study, we determined regional atrophy within 21 patients AD 16 subjects MCI compared to 20 healthy elderly using deformation-based morphometry MRI scans. We assessed effects on derived from high-resolution diffusion...
Recent neuroimaging studies of Alzheimer's disease (AD) have emphasized topographical similarities between AD-related brain changes and a prominent cortical association network called the default-mode (DMN). However, specificity distinct imaging abnormalities for DMN compared to other intrinsic connectivity networks (ICNs) limbic heteromodal cortex has not yet been examined systematically. We assessed regional amyloid load using AV45-PET, neuronal metabolism FDG-PET, gray matter volume...
Abstract Background The European Alzheimer's Disease Consortium and Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used as the standard truth to train new tracers, validate automated algorithms. Training requires large representative data sets segmented hippocampi. This work aims produce set HarP labels for proper training certification tracers Methods Sixty‐eight 1.5 T 67 3...
Amyloid deposition and neurofibrillary degeneration in Alzheimer's disease specifically affect discrete neuronal systems, but the underlying mechanisms that render some brain regions more vulnerable to pathology than others remain largely unknown. Here we studied molecular properties these distinct regional vulnerabilities by analysing disease-typical neuroimaging patterns of amyloid neurodegeneration relation gene expression profiles human brain. Graded brain-wide vulnerability were...