A5081327813- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Radiopharmaceutical Chemistry and Applications
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Treatment of Major Depression
- Schizophrenia research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Chemical Reactions and Isotopes
- Lanthanide and Transition Metal Complexes
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Synthesis and Biological Evaluation
- Drug Transport and Resistance Mechanisms
- Genetic Neurodegenerative Diseases
- Ion channel regulation and function
- Glioma Diagnosis and Treatment
- Phosphodiesterase function and regulation
- Pharmacological Receptor Mechanisms and Effects
- Electroconvulsive Therapy Studies
- Pharmacological Effects and Toxicity Studies
Karolinska Institutet
2016-2025
Stockholm County Council
2016-2025
Stockholm Health Care Services
2016-2024
Karolinska University Hospital
2012-2022
AstraZeneca (Sweden)
1989-2022
AstraZeneca (Canada)
2022
Nanyang Technological University
2014-2021
Yale University
2021
Vita-Salute San Raffaele University
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
The intestinal microbiota helps to maintain the integrity of blood-brain barrier in fetal and adult mice.
The study examined the influence of losses in dopaminergic function on age-related cognitive deficits.Eleven healthy subjects (21-68 years age) completed a set tasks used to assess perceptual speed and episodic memory. D(2) receptor binding was measured caudate putamen by using positron emission tomography.A gradual deterioration found for all both striatal structures. Statistical control eliminated variation, whereas residual effects were seen after analysis controlled age.D(2) is more...
[ 11 C]Raclopride binding to central D 2 -dopamine receptors in humans has previously been examined by positron emission tomography (PET). Based on the rapid occurrence of equilibrium, a saturation analysis developed for determination receptor density ( B max ) and affinity K d ). For PET measurements obtained with other ligands, kinetic three-compartment model used. In present study, brain uptake C]raclopride was analyzed further applying both an equilibrium data from four experiments each...
The regional distributions of monoamine oxidase (MAO) types A and B have been identified in human brain vivo with intravenously injected 11 C-labeled suicide enzyme inactivators, clorgyline L-deprenyl, positron emission tomography. rapid uptake retention radioactivity for both C tracers indicated irreversible trapping. anatomical distribution paralleled the MAO autopsy material. corpus striatum, thalamus, brainstem contained high activity. magnitudes [ C]clorgyline L-[ C]deprenyl were...
Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests role for neuroinflammation, no study has directly provided of brain glial activation in FM. In this study, we conducted Positron Emission Tomography (PET) using [11C]PBR28, which binds to the translocator protein (TSPO), upregulated activated microglia astrocytes. To enhance statistical power generalizability,...
Pioneered with the invention of <sup>11</sup>C-Pittsburgh compound B, amyloid-β imaging using PET has facilitated research in Alzheimer disease (AD). This approach promise for diagnostic purposes and evaluation disease-modifying therapies. Broad clinical use requires an <sup>18</sup>F-labeled radioligand high specific low nonspecific binding. The aim present study was to examine <sup>18</sup>F-AZD4694 human subjects. <b>Methods:</b> Six control subjects 10 clinically diagnosed AD patients...
Impaired mitochondrial function, oxidative stress and formation of excessive levels reactive oxygen species play a key role in neurodegeneration Parkinson’s disease. Myeloperoxidase is generating enzyme expressed by microglia. The novel compound AZD3241 selective irreversible inhibitor myeloperoxidase. hypothesized mechanism action involves reduction leading to sustained neuroinflammation. purpose this phase 2a randomized placebo controlled multicentre positron emission tomography study was...
A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately treatment of α-synuclein-related diseases. Here we show that PET ligand, [
Abstract Several neurochemical in vitro and vivo imaging studies have been aimed at characterizing the localization of serotonin receptors transporters human brain. In this study, a detailed comparison distribution number 5‐HT receptor subtypes transporter was carried out using postmortem brain tissue. Anatomically adjacent whole hemisphere sections were incubated with specific radioligands for 1A , 1B 2A 4 transporter. The autoradiograms revealed different laminar regional patterns...
A patient with an anaplastic (malignant) astrocytoma was examined computed tomography (CT) and positron emission (PET), in the latter case using [68Ga]EDTA, [11C]glucose. [11C]methionine. The CT examination as well [68Ga]EDTA study showed a small tumor located region of head left caudate nucleus. [11C]glucose increased uptake on same region, did [11C]methionine examination, but also considerable entire thalamic region. died 15 days after histologic evaluation thin sections obtained at...
<h3>Background</h3> The clinical efficacy of dopamine D<sub>2</sub>receptor antagonism on the psychotic symptoms schizophrenia has been widely demonstrated. However, most in vivo imaging studies have not able to detect significant changes striatal D<sub>2</sub>receptors schizophrenia. On other hand, a number reported abnormalities cerebral cortex aim this study was examine extrastriatal patients with <h3>Methods</h3> Eleven drug-naive male were examined positron emission tomography using...
Abstract The cocaine congener β‐CIT has been labeled with 11 C for positron emission tomographic (PET) studies of the dopamine transporter. In present autoradiographic study on human' brain sections and PET monkey human [ C]β‐CIT accumulated markedly in striatum. binding striatum was selective to thalamus an intermediate level displaced by compounds having affinity norepinephrine serotonin transporters. neocortical a low could be only citalopram, uptake inhibitor. A high dose intravenously...
<b><i>Objective:</i></b> To test the hypothesis that in mesial temporal lobe epilepsy (MTLE) there is involvement outside of structures and this affects serotonin systems, thus suggesting a mechanism for affective symptoms population. <b><i>Methods:</i></b> Serotonin 5-HT<sub>1A</sub> receptor binding was studied with PET [Carbonyl-<sup>11</sup>C]WAY-100 635 14 patients (6 left-, 8 right-sided focus) controls. The potential calculated hippocampus, amygdala, orbitofrontal, insular, lateral...