A5032672419- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Hypothalamic control of reproductive hormones
- Neuroscience and Neuropharmacology Research
- Autopsy Techniques and Outcomes
- Restraint-Related Deaths
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Prion Diseases and Protein Misfolding
- Estrogen and related hormone effects
- Muscle metabolism and nutrition
- Menopause: Health Impacts and Treatments
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Ovarian function and disorders
- Neuropeptides and Animal Physiology
- Forensic Toxicology and Drug Analysis
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Global Maritime and Colonial Histories
- Antibiotics Pharmacokinetics and Efficacy
- Medical Malpractice and Liability Issues
- Religion, Society, and Development
- Neurological diseases and metabolism
University of Debrecen
2024
Semmelweis University
2011-2020
UNSW Sydney
2020
University of Bern
2016
University of Basel
2013
Somogy Megyei Kaposi Mór Oktató Kórház
2007-2012
Cleveland Clinic
1994-1997
Leipzig University
1993
Universitäts Frauenklinik
1978
Kisspeptin signaling via the kisspeptin receptor G-protein-coupled receptor-54 plays a fundamental role in onset of puberty and regulation mammalian reproduction. In this immunocytochemical study we addressed (i) topography, (ii) sexual dimorphism, (iii) relationship to gonadotropin-releasing hormone (GnRH) neurons (iv) neurokinin B content kisspeptin-immunoreactive hypothalamic human autopsy samples. females, axons formed dense periventricular plexus profusely innervated capillary vessels...
Estrogen has been shown to influence several brain functions as well the expression of neuropsychiatric diseases. To date, two estrogen receptor (ER) subtypes have identified, ERα and ERβ. messenger ribonucleic acid (mRNA) distribution in human forebrain was recently characterized, highest found restricted areas amygdala hypothalamus. However, no information exists with regard ERβ mRNA brain. this end, anatomical pattern investigated present study. Overall, hybridization signal relatively...
The European Council of Legal Medicine (ECLM) is the body established in 1992 to represent practitioners forensic & legal medicine and composed delegates countries Union (EU) from other which form part Europe a current total 34 member countries. aims this study were determine status undergraduate teaching curriculum medical studies ECLM use results whether it would be appropriate develop new guidelines standards for harmonising content training across A detailed questionnaire was sent all...
Background and purpose Cerebrospinal fluid ( CSF ) tau neurofilament light chain NF ‐L) proteins have proved to be reliable biomarkers for neuronal damage; however, there is a strong need blood‐based tests. Methods The present study included 132 autopsy cases with rapidly progressive neurological syndromes, including Alzheimer disease AD (21), sporadic (65) genetic (21) Creutzfeldt–Jakob CJD ), 25 vascular, neoplastic inflammatory alterations, additionally 18 healthy control individuals. ‐L...
μ Opioid receptors are critical for heroin dependence, and A118G SNP of the opioid receptor gene ( OPRM1 ) has been linked with abuse. In our population European Caucasians n = 118), ≈90% 118G allelic carriers were users. Postmortem brain analyses showed genotype associated transcription, translation, processing human striatal neuropeptide system. Whereas down-regulation preproenkephalin preprodynorphin genes was evident in all users, effects exaggerated subjects most prominent nucleus...
Striatal enkephalin and dynorphin opioid systems mediate reward negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) prodynorphin (PDYN) genes in relation heroin abuse gene expression the human striatum relevance genetic dopaminergic tone, critical for drug striatal function. Heroin was significantly associated with PENK polymorphic 3′ UTR dinucleotide (CA) repeats; 79% subjects homozygous 79-bp allele were abusers. Such...
Abstract: The human estrogen receptor (ER) α gene is transcribed from multiple promoters, generating mRNA isoforms with unique 5′ ends in the untranslated region. In present study, alternative promoters were shown to regulate ERα expression different neuronal populations of brain. By using situ hybridization histochemistry, A and B but not C promoter, found be active forebrain. isoform promoter was expressed low levels most brain areas where present. contrast, more restricted, localized...
Recent identification of the second estrogen receptor (ER) isoform (ER-beta) within GnRH neurons rodent brain has generated much enthusiasm in field neuroendocrine research by questioning dogma that cells do not directly sense changes circulating estrogens.To address issue whether human hypothalamus also contain ER-beta, we have performed dual-label immunocytochemical studies.Tissue sections were prepared from autopsy samples male individuals (n = 8; age < 50 yr), with sudden causes death....
Negative affect is critical for conferring vulnerability to opiate addiction as reflected by the high comorbidity of abuse with major depressive disorder (MDD). Rodent models implicate amygdala prodynorphin (Pdyn) a mediator negative affect; however, evidence PDYN involvement in human limited. Here, we found reduced mRNA expression postmortem nucleus periamygdaloid cortex (PAC) both heroin abusers and MDD subjects. Similar humans, rats that chronically self-administered had Pdyn PAC at time...
Cocaine- and amphetamine-regulated transcript (CART) is a recently discovered anorexigenic peptide. In rodents, CART inhibits food intake expressed in the alpha-MSH- but not orexigenic neuropeptide Y (NPY)- agouti-related protein (AGRP)-synthesizing neurons of arcuate nucleus. To understand whether similarly feeding-related neuronal groups human hypothalamus as observed colocalization with alpha-MSH, NPY, AGRP, melanin-concentrating hormone was studied using double-labeling...
Abstract The current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment chromatin accessibility the striatum in heroin users and matched controls. Our study reveals distinct neuronal non-neuronal epigenetic signatures, identifies locus proximity gene encoding tyrosine kinase FYN as most affected region neurons. expression, activity phosphorylation its target Tau are increased...