A5065216569- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Receptor Mechanisms and Effects
- Neuroendocrine regulation and behavior
- Chemical Synthesis and Analysis
- Pain Mechanisms and Treatments
- Immune cells in cancer
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Neuroendocrine Tumor Research Advances
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- Photoreceptor and optogenetics research
- Molecular Biology Techniques and Applications
- Aluminum toxicity and tolerance in plants and animals
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
University of Szeged
2013-2024
University of Colorado Denver
1993
National Institutes of Health
1990-1991
National Institute on Alcohol Abuse and Alcoholism
1991
University of Arizona
1985-1987
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign and synthesis of conformationally constrained somatostatin analogs with high potency specificity for .mu. opioid receptorsJohn T. Pelton, Wieslaw Kazmierski, Karoly Gulya, Henry I. Yamamura, Victor J. HrubyCite this: Med. Chem. 1986, 29, 11, 2370–2375Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November...
Abstract: The in vivo and vitro effects of A1 on the cholinergic system rat brain were studied. amount accumulated after chronic, intraperitoneal administration aluminum gluconate (Al‐G) or AlCl3, both at a dose 1 mg/ml/100 g body weight, increased frontal parietal cortices, hippocampus, striatum. Significantly decreased choline acetyltransferase activities chronic Al treatment measured cortex, striatum, but not cortex. acetylcholinesterase activity was changed significantly any area...
A series of cyclic, conformationally restricted analogs somatostatin have been prepared and tested for their ability to inhibit the binding [3H]naloxone [D-Ala2, D-Leu5] [3H]enkephalin rat brain membranes. The most potent analog, D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 where Pen is penicillamine in [D-Phe5, Cys6, Tyr7, D-Trp8, Pen11]somatostatin-(5-12)-octapeptide amide, exhibited high affinity mu-opiate receptors (IC50 value = 3.5 nM), being 7800 times more than somatostatin. cyclic...
The intraventricular administration of vasopressin or DDAVP (desmopressin acetate) increased the brain water content from 78.2% to 79.2-79.5%. This was achieved without an accompanying load. applied load alone did not increase brain. There no significant difference in between animals treated with and intravenous receiving only vasopressin. olfactory bulbs control 3.8% higher than that hemispheres. While hemispheres by 1.3%, so 1.7% subsequent DDAVP. Measurement electrolyte conclusive as...
The cyclic, conformationally restricted octapeptide [3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP) was synthesized and its binding to mu opioid receptors characterized in rat brain membrane preparations. Association rates (k+1) of 1.25 x 10(8) M-1 min-1 2.49 at 25 37 degrees C, respectively, were obtained, whereas dissociation (k-1) the same temperatures 1.93 10(-2) 1.03 10(-1) respectively. Saturation isotherms [3H]CTOP membranes gave apparent Kd values 0.16 0.41 nM Maximal...
Microglial activation results in profound morphological, functional and gene expression changes that affect the pro- anti-inflammatory mechanisms of these cells. Although statins have beneficial effects on inflammation, they not been thoroughly investigated for their ability to microglial functions. Therefore rosuvastatin, one most commonly prescribed drugs cardiovascular therapy, either alone or combination with bacterial lipopolysaccharide (LPS), were profiled pure cultures derived from...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents cytoplasm. Defects in autophagy are implicated development various age-dependent degenerative disorders such cancer, neurodegeneration tissue atrophy, accelerated aging. To promote basal levels process pathological settings, we previously screened small molecule library novel autophagy-enhancing factors that inhibit myotubularin-related phosphatase MTMR14/Jumpy, negative regulator autophagic...
Our goal was to characterize the neuroprotective properties of orally administered phosphatidylcholine (PC) in a rodent model systemic inflammation. Sprague-Dawley rats were killed at 3 h, 1 day, days, or 7 days after i.p. administration lipopolysaccharide (LPS) determine plasma levels tumor necrosis factor α (TNF-α) and interleukin 6 cytokines. The control group one LPS-treated animals nourished with standard laboratory chow, whereas another received special diet enriched 1% PC for 5 before...
Light microscopic autoradiography was used to visualize the neuroanatomical distribution of rat brain delta opioid receptors. Slide-mounted sections were labeled with [3H]-[2-D-penicillamine, 5-D-penicillamine]enkephalin([3H]DPDPE), a highly selective agonist. Saturation isotherms [3H]DPDPE binding thaw-mounted slices gave maximal number sites 79.9 fmol/mg protein and an apparent dissociation constant (Kd) 6.3 nM. DPDPE met-enkephalin inhibited high affinity (lC50 values 13.8 nM,...
Abstract We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-penetrable analog N -(2-(dimethylamino)ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2-carboxamide (SZR104) both in vivo vitro. Here, we identified cytomorphological KYNA SZR104 secondary microglial cultures established from newborn rat forebrains. quantitatively analyzed selected morphological aspects microglia control (unchallenged), lipopolysaccharide (LPS)-treated (challenged), KYNA- or...