A5063128024- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Microbial metabolism and enzyme function
- Microfluidic and Capillary Electrophoresis Applications
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Eicosanoids and Hypertension Pharmacology
- Neurological Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Inflammatory mediators and NSAID effects
- Biochemical Acid Research Studies
- Pharmacogenetics and Drug Metabolism
- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Microbial Natural Products and Biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Mast cells and histamine
- Biochemical and biochemical processes
- Biochemical effects in animals
Semmelweis University
2007-2018
Hungarian Academy of Sciences
1982-2011
University of Debrecen
1996-2010
University of Florence
1999
United States Department of Agriculture
1999
University of Massachusetts Chan Medical School
1998
Magyar Agrár- és Élettudományi Egyetem
1986-1991
Országos Korányi Tbc és Pulmonológiai Intézet
1985
Medical Research Council
1963-1964
Eötvös Loránd University
1963
To develop novel neuroprotective agents, a library of arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, number highly potent selective oxidase B inhibitors were identified. Selected compounds also neuroprotection in vitro studies with PC-12 cells treated 6-OHDA rotenone, respectively. It observed that some the yielded marked increase survival neurotoxins. This indicates these propargylamines are able to confer protection...
Abstract Labelled histamine was taken up into cultured glial cells of chick embryonic brain by a system with high affinity for and diffusion. The active uptake, occurring at low concentrations the amine, Na + dependent gave an apparent K m 0.24 μM V max 0.31 pmol X mg protein −1 min . uptake completely blocked desmethylimipramine (K i = 2.5 μM) partially agonists histamine‐N‐methyltransferase blockers 4‐methylhistamine 2‐methylhistamine (I 30 values obtained were 2 5 μM). Other psychoactive...
The effects of endothelin on blood pressure and in vivo aggregation platelets were studied anaesthetized beagle dogs. Intravenous administration (0.03‐0.3 nmol kg −1 ) resulted a dose‐dependent transient hypotension followed by long‐lasting hypertension inhibition platelet aggregation. These changes accompanied elevation plasma 6‐keto prostaglandin F 1α levels. Pretreatment the animals with acetylsalicylic acid significantly attenuated both vascular antiaggregatory responses to endothelin....
Platelet aggregation induced by ADP, collagen and platelet-activating factor was studied in common (migraine without aura) classical migraine with patients during between attacks. The EC 50 * values for ADP were significantly higher, whilst that lower headache-free intervals compared to healthy volunteers. obtained sufferers symptom-free periods similar those of controls. During attacks, the value but not factor, higher than In subjects a positive correlation found collagen-induced...