A5040655181- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Pancreatitis Pathology and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Phytase and its Applications
- Immune Cell Function and Interaction
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antiplatelet Therapy and Cardiovascular Diseases
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Nutritional Studies and Diet
- Mitochondrial Function and Pathology
Semmelweis University
2013-2024
Linköping University
2014
University of California, Irvine
1992-2011
Bajcsy-Zsilinszky Kórház és Rendelőintézet
2006
Hungarian Academy of Sciences
2005
OBJECTIVE—To compare the clinical parameters, C-peptide levels, pattern of islet cell-specific autoantibodies, and prevalence predisposing genotypes in subjects with latent autoimmune diabetes adults (LADA) those adult-onset type 1 rapid progression. RESEARCH DESIGN AND METHODS—We evaluated autoantibodies 54 LADA, 57 diabetic, 190 2 diabetic patients. Islet cell were also compared between subgroups newly diagnosed patients LADA childhood-onset diabetes. The genetic study was performed...
Aims C‐peptide secretion is currently the only available clinical biomarker to measure residual β‐cell function in type 1 diabetes. However, natural history of decline after diagnosis can vary considerably dependent upon several variables. We investigated shape over time from diabetes onset relation age at diagnosis, haemoglobin A1c ( HbA1c ) levels and insulin dose. Methods analysed data 3929 patients recruited seven European centres representing all groups disease (childhood, adolescence...
Aim of this trial was to test whether heat shock protein peptide DiaPep277 treatment in adult and paediatric patients with recent-onset type 1 diabetes (T1D) is safe it can preserve endogenous insulin production.Two studies were performed a prospective, multicentre, double-blind, placebo-controlled trial. Fifty (study p520, aged 16-44 years) 49 p521, 4-15 T1D treated subcutaneously at four different time points 0.2 mg or 1.0 versus placebo followed for 18 months. Adult mg, 2.5 placebo....
Objective Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was independent predictor of C-peptide decline 1-year post-diagnosis. Design Multicentre longitudinal study carried out and up follow-up. Methods Data on were collected from seven diabetes centres Europe. Patients grouped according age (<5 years, n =126; >5 years <10...
Abstract Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently use are either too complicated or require data that unavailable on admission lack sufficient predictive value. We therefore aimed to develop tool aid prediction. The XGBoost machine learning algorithm processed from 2387 patients with AP. confidence of model was estimated by bootstrapping method and interpreted via 10th 90th percentiles prediction scores. Shapley...
Abstract Background Hypoxia inducible factor-1 alpha (HIF-1α) is a transcription factor that plays an important role in neo-vascularisation, embryonic pancreas beta-cell mass development, and beta cell protection. Recently non synonymous single nucleotide polymorphism (g.C45035T SNP, rs11549465) of HIF-1α gene, resulting the p.P582S amino acid change has been shown to be associated with type 2 diabetes (T2DM) Japanese population. Our aim was replicate these findings on Caucasian (Hungarian)...
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether per se induces functional alterations the complement system hampering activation during infection is unknown. We investigated key elements of bacterial type 2 mellitus (T2DM) compared them to non-diabetic (ND) individuals. Using a prospective design, we included 197 T2DM 196 ND subjects, all clinical diagnosis acute community-acquired infections. Functional activities ficolin-3-mediated lectin (F3-LP),...
The absolute or relative lack of insulin is the key factor in pathogenesis diabetes mellitus. Although connection between loss function mutations WFS1 gene and DIDMOAD-syndrome including mellitus underpins significance wolframin pathogenesis, exact role polymorphic variants development type 1 2 has not been discovered yet. In this analysis, 787 patients with 900 healthy people participated. Genotyping 7 SNPs was carried out by TaqMan assays. Association study performed χ2-test combination...
Abstract Aims Ketosis‐prone type 2 diabetes was defined by the World Health Organization in 2019. According to literature, diagnosis is based on presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta‐analysis assessed prevalence clinical characteristics ketosis‐prone among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis. Methods The systematic search performed five main databases as 15 October 2021 without restrictions. We calculated...
We have developed a two-dimensional computer model to predict the temperature increase of retina during femtosecond corneal laser flap cutting. Simulating typical clinical setting for 150-kHz iFS advanced (0.8- 1-μJ pulse energy and 15-s procedure time at wavelength 1053 nm), is 0.2°C. Calculated profiles show good agreement with data obtained from ex vivo experiments using human cadaver retina. Simulation results different commercial lasers indicate that in situ keratomileusis insufficient...
Within the human MHC region larger stretches of conserved DNA, called ancestral haplotypes exist. However, many contain only fragments an haplotype. Little is known, however, on relative distribution to their fragments. Therefore we determined frequency carriers whole haplotype 8.1 (AH8.1) and its in 127 healthy Hungarian people, 101 Ohioian females, nine families. The HLA-DQ2, HLA-DR3(17), RAGE -429C allele, mono-S-C4B genotype, HSP70-2 1267G allele TNF -308A (TNF2) were used as markers...
Abstract Background This article presents a clinically characterization of the mitochondrial DNA mutation (A3243G) associated with maternally inherited diabetes and deafness (MIDD) syndrome in two families. Methods Six patients MIDD one mutation‐positive relative normal glucose tolerance (NGT) were examined. Fasting serum C‐peptide was measured all subjects compared controls having NGT (n = 14). response to an intravenous test (IVGTT) investigated diabetic not treated insulin 3) healthy...
The prevalence rate and clinical significance of the metabolic syndrome in type 1 diabetic patients are not well established. aim this study was to estimate adult with diabetes. Patients diabetes (n=533; age: 35.6+/-11.6 years; duration diabetes: 18.0+/-11.1 x+/-SD) were consecutively enrolled from 11 outpatient departments. Data on medical history, actual treatment, anthropometric laboratory parameters as blood pressure registered while eating habits physical activity evaluated by...
Cytofluorometric analysis using specific monoclonal antibodies directed against the T cell antigens Thy-1.2, CD4, CD8, CD4V/J(8.1+8.2+8.3), and antigen Mac-1 expressed by mature macrophages NK cells were used to characterize quantify phenotypes of (1) unfractionated Percoll gradient fractionated in situ islet immune isolated from prediabetic diabetic female NOD mouse spleens. We found mice that majority (-70%) Thy-1.2 positive cells. CD4 (-40%) most abundant phenotype together with double...