A5000101220- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Pharmacology and Obesity Treatment
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Chronic Disease Management Strategies
- Diabetes Management and Education
- Pain Mechanisms and Treatments
- Hormonal Regulation and Hypertension
Bajcsy-Zsilinszky Kórház és Rendelőintézet
2015-2024
Semmelweis University
2011-2021
Target (United States)
2021
77 Elektronika (Hungary)
2020
University of Pecs
2019
ID Genomics (United States)
2016
Magyar Agrár- és Élettudományi Egyetem
2009
Institut Cardiovasculaire Paris Sud
2004
Instituto de Nutricion e Higiene de los Alimentos
2004
King's College Hospital
2003
OBJECTIVE—Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (HEART2D) is a multinational, randomized, controlled trial designed to compare the effects of prandial versus fasting glycemic control risk for cardiovascular outcomes patients with type diabetes after acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS—Patients (type diabetes, aged 30–75 years) were randomly assigned within 21 days AMI 1)...
Pioglitazone, a thiazolidinedione, improves glycemic control primarily by increasing peripheral insulin sensitivity in patients with type 2 diabetes, whereas metformin, biguanide, exerts its effect decreasing hepatic glucose output. In the first head-to-head, double-blind clinical trial comparing these two oral antihyperglycemic medications (OAMs), we studied of 32-wk monotherapy on and 205 recently diagnosed diabetes who were naive to OAM therapy. Subjects randomized either 30 mg...
To test whether microalbuminuria in patients with type 2 diabetes and hypertension is primarily dependent on the severity of hypertension, to compare effectiveness two antihypertensive drugs opposite effects renin-angiotensin system [the diuretic, indapamide sustained release (SR), an angiotensin-converting enzyme inhibitor, enalapril] reducing microalbuminuria.A multinational, multicentre, controlled, double-blind, double-dummy, randomized, two-parallel-groups study over 1 year.After a...
Microalbuminuria in diabetes is a risk factor for early death and an indicator aggressive blood pressure (BP) lowering. We compared combination of 2 mg perindopril/0.625 indapamide with enalapril monotherapy on albumin excretion rate (AER) patients type diabetes, albuminuria, hypertension 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one (systolic BP ≥140 mm Hg, <180 diastolic <110 Hg) were randomly assigned (age 59±9 years, 77%...
Both genetic and environmental factors play a role in the pathogenesis of type 2 diabetes cardiovascular diseases. The magnitude influences may vary different populations can be investigated by twin studies. In this cross-sectional study, 101 (63 monozygotic 38 dizygotic) adult pairs (n = 202; mean age: 44.3 ± 15.8 years) were investigated. Past medical history was recorded physical examination performed. Fasting venous blood samples taken for measuring laboratory parameters. For assessing...
Background: Genetics have a strong influence on calcified atherosclerotic plaques; however, data regarding the heritability of noncalcified plaque volume are scarce. We aimed to evaluate genetic versus environmental influences calcium (coronary artery calcification) score, and volumes by coronary computed tomography angiography in adult twin pairs without known disease. Methods: In prospective BUDAPEST-GLOBAL (Burden Atherosclerotic Plaques Study Twins—Genetic Loci Burden Lesions) classical...
Aim of this trial was to test whether heat shock protein peptide DiaPep277 treatment in adult and paediatric patients with recent-onset type 1 diabetes (T1D) is safe it can preserve endogenous insulin production.Two studies were performed a prospective, multicentre, double-blind, placebo-controlled trial. Fifty (study p520, aged 16-44 years) 49 p521, 4-15 T1D treated subcutaneously at four different time points 0.2 mg or 1.0 versus placebo followed for 18 months. Adult mg, 2.5 placebo....
To evaluate neural dysfunction in subjects with impaired glucose tolerance (IGT).For this study, 46 IGT and 45 healthy volunteers underwent detailed neurological assessment. Cardiovascular autonomic function was assessed by standard cardiovascular reflex tests, heart rate variability characterized the triangle index. Sensory nerve using Neurometer (for current perception threshold) Medoc devices. Peak plantar pressure measured dynamic pedobarography, symptoms were graded neuropathy total...
: Microvascular complications are responsible for a major proportion of the burden associated with diabetes contributing to substantial morbidity, mortality, and healthcare in people diabetes. Retinopathy, nephropathy, neuropathy constitute leading causes blindness, end-stage renal disease, lower-extremity amputations, respectively. Since efficacy causal therapies diabetic microvascular is limited, especially type 2 diabetes, there an unmet need adjunct treatments which should be effective...
Abstract Background Non‐alcoholic fatty liver disease ( NAFLD ) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims To analyse heritability of and its association with abnormal vascular parameters a large twin cohort. Methods Anthropometric lipid metabolic were obtained from 208 adult Hungarian twins (63 monozygotic 41 dizygotic pairs; 58 men 150 women; age 43.7 ± 16.7 years). B‐mode ultrasonography was performed detect...
Objective: Central blood pressure and aortic stiffness have been consistently reported as strong cardiovascular risk factors. Twin studies by comparing identical with nonidentical twins produce information on the relative contribution of genes environment. Methods: One hundred fifty-four monozygotic (MZ) 42 dizygotic (DZ) twin pairs (age 43 ± 17 years) from Hungary United States underwent brachial central augmentation index (AIx), pressure, pulse wave velocity (PWV) measurements invasively...
Abstract Aims To evaluate comprehensively the safety of dapagliflozin in patients with type 2 diabetes (T2DM), emphasis placed on potential concerns related to sodium‐glucose co‐transporter‐2 inhibitor class. Methods In Dapagliflozin Effect Cardiovascular Events – Thrombolysis Myocardial Infarction 58 (DECLARE‐TIMI 58) study, 17 160 T2DM were randomized or placebo and followed for a median 4.2 years. Safety was evaluated 143 receiving at least one dose study drug. Results Acute kidney injury...
Shift workers may be at risk of different diseases. In order to assess cardiometabolic in shift workers, a cross-sectional study was performed among active workers. A total 481 (121 men, 360 women) were investigated; most them employees light industry (58.2%) or public services (23.9%). Past medical history recorded and physical examination performed. Questionnaires used characterize daily activity. Fasting venous blood sample collected for measuring laboratory parameters. Data from (n =...
AimTo obtain correct evaluation of the prevalence rate diabetes mellitus and impaired fasting glycemia (IFG) in Hungary.MethodThe study was performed on a nationally representative sample covered by Hungarian General Practitioners' Morbidity Sentinel Stations Program. The source population consisted all persons aged 20-69 years who were registered with participating centers. rates adjusted to age sex distribution total population. Fasting blood samples 1803 participants evaluated. Response...