Corrado Fagnani
A5060274520- Cognitive Abilities and Testing
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Cardiovascular Health and Disease Prevention
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Multiple Sclerosis Research Studies
- Genetics and Neurodevelopmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Psychological Well-being and Life Satisfaction
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Ethics in Clinical Research
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Musculoskeletal pain and rehabilitation
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
- Shoulder Injury and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Schizophrenia research and treatment
- Heart Rate Variability and Autonomic Control
Istituto Superiore di Sanità
2015-2024
National Center for Epidemiology
2016
National Institute of Epidemiology
2012
Semmelweis University
2012
Sapienza University of Rome
2012
Hungarian Academy of Sciences
2012
University of Padua
2012
National Centre for Disease Prevention and Control
2012
National Institutes of Health
2010
Université Laval
2007
Body mass index (BMI), a simple anthropometric measure, is the most frequently used measure of adiposity and has been instrumental in documenting worldwide increase prevalence obesity witnessed during last decades. Although this overweight thought to be mainly due environmental changes, i.e., sedentary lifestyles high caloric diets, consistent evidence from twin studies demonstrates heritability importance genetic differences for normal variation BMI. We analysed self-reported data on BMI...
Abstract Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ sex, age global regions lacking. We conducted an individual-based pooled analysis 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion height explained shared factors was greatest in early childhood, these effects remained present until adulthood. Accordingly, the relative contribution...
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks changes methylation adult stem cells during lifetime are still largely unknown. Here, profiling mesenchymal (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites aging. As sequences were marks. Most importantly, strongly active mark H3K4me1 suggesting...
Depression is a worldwide public health concern. The World Health Organization (WHO) has recently recommended the implementation of programs for strengthening subjective well-being (SWB) to reduce mental disorders, including depression. Also, in 2013, European member-states agreed on single measure SWB, i.e., life satisfaction, monitoring progress SWB WHO policy framework, 'Health 2020'. Life satisfaction strongly associated with depression, therefore, its use as indicator could be suitable...
To investigate the interplay between genetic factors influencing baseline level and changes in BMI adulthood.A longitudinal twin study of cohort Finnish twins (N = 10,556 individuals) aged 20-46 years at was conducted followed up 15 years. Data on weight height were obtained from mailed surveys 1975, 1981, 1990.Latent growth models revealed a substantial influence males females (heritability (h(2)) 80% (95% confidence interval 0.79-0.80) for h(2) 82% (0.81, 0.84) females) moderate-to-high...
Background Smokers tend to weigh less than never smokers, while successful quitting leads an increase in body weight. Because smokers and non-smokers may differ genetic environmental family background, we analysed data from twin pairs which the co-twins differed by their smoking behaviour evaluate if association between mass index (BMI) remains after controlling for background. Methods findings The international CODATwins database includes information on BMI measured 1960 2012 156,593...
It is debated whether multiple sclerosis (MS) might result from an immunopathological response toward active Epstein-Barr virus (EBV) infection brought into the central nervous system (CNS) by immigrating B cells. Based on this model, a relationship should exist between local immune milieu and EBV status in MS brain. To test hypothesis, we analyzed expression of viral cellular genes brain-infiltrating cells.Twenty-three postmortem snap-frozen brain tissue blocks 11 patients with progressive...
Between 25% and 30% of children adolescents experience sleep disorders. These disorders are complex phenotypes that regulated by many genes, the environment, gene-environment interactions. The objective this study was to evaluate contribution genetic environmental factors behaviors in early childhood contribute knowledge on appropriate therapeutic approaches, using a twin design.Data sleeping behavior were collected from 314 18-month-old pairs (127 monozygotic 187 dizygotic)using...
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m 2 ) have been under intensive genetic research. However, it is still largely unknown whether how heritability estimates vary between populations. Opportunities to address this question increased recently because establishment many new twin cohorts increasing accumulation data in established cohorts. We started a research project...
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete pairs born 1886–1994. Although variance showed a generally increasing trend the cohorts, heritability estimates (0.69-0.84 in men 0.53-0.78 women) did not present any clear pattern secular changes. Comparing geographic-cultural regions (Europe,...
Abstract Knowledge about the balance between heritable and nonheritable risk in multiple sclerosis (MS) is based on twin studies high‐prevalence areas. In a study that avoided ascertainment limitations directly compared continental Italy (medium‐prevalence) Sardinia (high‐prevalence), we ascertained 216 pairs from 34,549 patients. This gives twinning rate of 0.62% among MS patients, significantly less than general population. Italy, probandwise concordance was 14.5% (95% confidence interval,...
Abstract A number of studies have provided evidence a significant familial aggregation for both asthma and hay fever, reported substantial comorbidity between the two conditions. However, far fewer, especially in Italy, aimed at clarifying origins such comorbidity. The main aims present study were (a) to estimate heritability (b) measure association fever individual level, (c) assess extent which genetic environmental factors, shared by conditions, mediate this association. twin method was...
Objective: Central blood pressure and aortic stiffness have been consistently reported as strong cardiovascular risk factors. Twin studies by comparing identical with nonidentical twins produce information on the relative contribution of genes environment. Methods: One hundred fifty-four monozygotic (MZ) 42 dizygotic (DZ) twin pairs (age 43 ± 17 years) from Hungary United States underwent brachial central augmentation index (AIx), pressure, pulse wave velocity (PWV) measurements invasively...