Narandalai Danshiitsoodol
A5024285555- Birth, Development, and Health
- Probiotics and Fermented Foods
- Gut microbiota and health
- Obesity, Physical Activity, Diet
- Microbial Metabolites in Food Biotechnology
- Genetic Associations and Epidemiology
- Enzyme Production and Characterization
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Cognitive Abilities and Testing
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
- Diet and metabolism studies
- Vestibular and auditory disorders
- Pharmacological Effects of Natural Compounds
- Biological and pharmacological studies of plants
- Bacterial biofilms and quorum sensing
- Protein Hydrolysis and Bioactive Peptides
- Nutrition, Genetics, and Disease
- Food Quality and Safety Studies
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Oral microbiology and periodontitis research
- Cancer therapeutics and mechanisms
- Biochemical Analysis and Sensing Techniques
Hiroshima University
2015-2024
The University of Melbourne
2018
University of Helsinki
2018
Qingdao Municipal Center for Disease Control and Prevention
2018
Semmelweis University
2018
Abstract Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ sex, age global regions lacking. We conducted an individual-based pooled analysis 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion height explained shared factors was greatest in early childhood, these effects remained present until adulthood. Accordingly, the relative contribution...
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m 2 ) have been under intensive genetic research. However, it is still largely unknown whether how heritability estimates vary between populations. Opportunities to address this question increased recently because establishment many new twin cohorts increasing accumulation data in established cohorts. We started a research project...
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete pairs born 1886–1994. Although variance showed a generally increasing trend the cohorts, heritability estimates (0.69-0.84 in men 0.53-0.78 women) did not present any clear pattern secular changes. Comparing geographic-cultural regions (Europe,...
Fermentation of medicinal herbs can be a significant technique to obtain bioactive compounds. Paeoniae Radix (PR) used in the present study is well-known herbal medicine that exhibits anti-inflammatory and immunomodulatory activity. The aim this explore possibility compound newly generated PR extract by fermentation with plant-derived lactic acid bacteria
We previously found that fermented extract of Dendrobium officinale using Lactobacillus plantarum GT-17F has a stronger antioxidant effect, especially in free radical scavenging. The result provided basis for further studies to evaluate the effectiveness D. preventing UV-mediated damage and photoaging humans. Therefore, this study, we aimed assess anti-aging efficacy with strain clinical trial, which was conducted as double-blind, placebo-controlled, randomized parallel-group comparative...
Background: Enlarged vestibular aqueduct (EVA) is a common inner ear malformation that can cause sensorineural hearing loss. It frequently associated with mutations in the SLC26A4 gene. This study aimed to investigate genetic basis of loss Mongolian patients EVA. Methods: Whole exome sequencing was performed 19 from 15 unrelated families diagnosed EVA with/without cochlear incomplete partition type II. All underwent high-resolution computed tomography temporal bone confirm diagnosis....
Background/Objectives: Medicinal herbs produce valuable substances with therapeutic potential. The chemical structures of those are often converted by gut microbiota. Our previous studies showed that several kinds bioactive molecules newly generated in fermented medicinal herbal extract plant-derived lactic acid bacteria (LABs). Methods: Atractylodes Japonica Rhizoma (AJR), which is designated as “Byakujutsu” Japan, a LAB strain IJH-SONE68 was prepared and whether the could help reduce...
In the present study, we have obtained two exopolysaccharide (EPS)-producing thermophilic lactic acid bacteria (LAB) that were isolated from tropical fruits of Thailand. The strains, designated LY45 and PY45, identified as Pediococcus pentosaceus Lactobacillus amylovorus, respectively. Both plant-derived LAB which produce neutral EPSs together with acidic one, can grow vigorously at 45°C even 50°C. Hyaluronidase (EC 3.2.1.35), catalyzes degradation hyaluronic acid, activates an inflammatory...
In the present study, effect of PLA on a periodontic pathogen, Aggregatibacter actinomycetemcomitans ( A. ), biofilm, and virulence-related genes was investigated. We confirmed that two lactic acid bacteria (LAB) strains isolated from plant sources, Lactiplantibacillus plantarum MSC-C2 Pediococcus pentosaceus K40, secrete into de Man, Rogosa & Sharpe (MRS) broth when supplemented with phenyl pyruvic (PPA) as precursor to PLA. Moreover, generated in fermentation broths medicinal...
ABSTRACT We have previously shown that the lactic acid bacterium Lactobacillus brevis 174A, isolated from Citrus iyo fruit, produces a bacteriocin designated brevicin which is comprised of two antibacterial polypeptides (designated brevicins 174A-β and 174A-γ). also found gene cluster, composed eight open reading frames (ORFs), contains genes for biosynthesis self-resistance to its own bacteriocin, transcriptional regulatory proteins. Some bacterial strains system start production at an...
There is evidence that birth size positively associated with height in later life, but it remains unclear whether this explained by genetic factors or the intrauterine environment. To analyze associations of weight, length and ponderal index from infancy through adulthood within mono- dizygotic twin pairs, which provides insights into role environmental individual-specific factors. This study based on data 28 cohorts 17 countries. The pooled included 41,852 complete pairs (55% monozygotic...
Inflammatory bowel disease (IBD) is an autoimmune characterized by chronic inflammation of the gastrointestinal tract. IBD includes Crohn's (CD) and ulcerative colitis (UC). CD can occur in any part tract, whereas UC mainly occurs colon rectum. We previously demonstrated that a novel exopolysaccharide (EPS) produced plant-derived bacterium, Lactobacillus paracasei IJH-SONE68, prevents improves contact dermatitis model mice via oral administration. To evaluate preventive effect EPS against...
A trend toward greater body size in dizygotic (DZ) than monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary age. We analyzed zygosity differences mean values variances of height mass index (BMI) among male female from infancy to old Data were derived an international database 54 twin cohorts participating the COllaborative project Development Anthropometrical measures Twins (CODATwins), included 842,951 BMI measurements aged 1 102 years....
Abstract The COllaborative project of Development Anthropometrical measures in Twins (CODATwins) is a large international collaborative effort to analyze individual-level phenotype data from twins multiple cohorts different environments. main objective study factors that modify genetic and environmental variation height, body mass index (BMI, kg/m 2 ) size at birth, additionally address other research questions such as long-term consequences birth size. started 2013 open all twin projects...
There is evidence that birthweight positively associated with body mass index (BMI) in later life, but it remains unclear whether this explained by genetic factors or the intrauterine environment. We analysed association between and BMI from infancy to adulthood within twin pairs, which provides insights into role of environmental individual-specific factors.This study based on data 27 cohorts 17 countries. The pooled included 78 642 individuals (20 635 monozygotic 18 686 same-sex dizygotic...
The genetic architecture of birth size may differ geographically and over time. We examined differences in the environmental contributions to birthweight, length ponderal index (PI) across geographical-cultural regions (Europe, North America Australia, East Asia) cohorts, how gestational age modifies these effects.Data from 26 twin cohorts 16 countries including 57 613 monozygotic dizygotic pairs were pooled. Genetic variations estimated using structural equation modelling.The variance...
It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins affected by the sex of their co-twin. We conducted an individual-based pooled analysis 21 twin cohorts 15 countries derived from COllaborative project Development Anthropometrical measures Twins (CODATwins), including 67,850 dizygotic individuals. Linear regression analyses showed having a co-twin sister were, on average, 31 g (95% CI 18 to 45) 0.16 cm 0.045 0.274)...
Lactobacillus plantarum SN35N, which has been previously isolated from pear, secretes exopolysaccharide (EPS). The aim of the present study is to characterize EPS chemically and find EPS-biosynthesizing gene cluster. demonstrates that strain produces an acidic carrying phosphate residue, composed glucose, galactose, mannose at a molecular ratio 15.0 : 5.7 1.0. We also show strongly inhibits catalytic activity hyaluronidase (EC 3.2.1.35), promoting inflammatory reaction. In study, we...
Some glycosides, which are detected in water extracts from medicinal plants, have been reported to be degraded into their aglycones by incubating with some microorganisms producing β-glucosidase. We shown that a plant-derived Lactobacillus plantarum SN13T harbors 11 open reading frames (ORFs) encoding the β-glucosidase enzyme and can grow vigorously several herbal extracts. In this study, we observed extract Artemisia princeps Pampanini (AP) fermented strain strongly inhibited release of...
A lactic acid bacterial strain, Lactobacillus plantarum SN35N, which has been isolated from the pear, secretes negatively charged acidic exopolysaccharide (EPS) to outside cells. We have previously found that SN35N-derived EPS inhibits catalytic activity of hyaluronidase (EC 3.2.1.35) promoting inflammation. The aim this study is find other health benefits EPS. exhibit an inhibitory effect against influenza virus (Alphainfluenzavirus Influenza virus) and feline calicivirus (Vesivirus Feline...
A lactic acid bacterium Lactobacillus paracasei IJH-SONE68, which was isolated from a fig leaf by our group, found to produce both acidic and neutral exopolysaccharides (EPSs). The nuclear magnetic resonance analysis demonstrates that the former EPS is composed primarily of mannose, latter one consists α-1, 6-linked glycan chains made N-acetylglucosamine (GlcNAc). presence GlcNAc polysaccharide first reported in prokaryotes. Furthermore, reveal EPS-biosynthetic gene organization IJH-SONE68...
In the present study, we isolated a lactic acid bacterium (LAB) from citrus iyo fruit and identified it as Lactobacillus brevis. This plant-derived LAB strain, designated 174A, produces bacteriocin consisting of two polypeptides brevicin 174A-β 174A-γ. Although each polypeptide itself displays antibacterial activity, ability is enhanced 100 fold by mixing both at 1 : ratio. Significantly, 174A inhibits even growth several pathogenic bacteria that are more resistant to lantibiotic...