A5101571785- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Corneal Surgery and Treatments
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Biomedical Research and Pathophysiology
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Macrophage Migration Inhibitory Factor
- Cancer-related Molecular Pathways
- Cholesterol and Lipid Metabolism
- Circular RNAs in diseases
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Biomarkers in Disease Prognosis
- Obesity, Physical Activity, Diet
- Cleft Lip and Palate Research
- Genetic Syndromes and Imprinting
- Birth, Development, and Health
- Genetic and Kidney Cyst Diseases
- Corneal surgery and disorders
- Periodontal Regeneration and Treatments
- Cancer-related gene regulation
- Viral Infections and Immunology Research
Yangtze University
2024
Chinese People's Liberation Army
2024
Xinqiao Hospital
2019-2022
Army Medical University
2019-2022
Central South University
2022
Xiangya Hospital Central South University
2022
Jiangmen Central Hospital
2021
Sun Yat-sen University
2019-2021
Qingdao University
2019
Affiliated Hospital of Qingdao University
2019
Purpose: Hematological parameters are considered to be associated with prognosis in various cancers.We designed a meta-analysis evaluate the prognostic significance of hematological parameters, including neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin (CRP/ALB), lymphocyte-to-monocyte (LMR), plasma fibrinogen level, Glasgow score (GPS), platelet-to-lymphocyte (PLR) and high-density lipoprotein cholesterol (HDL-C) on clinical outcomes nasopharyngeal carcinoma (NPC).Methods:...
Bromocriptine, the most commonly used dopamine (DA) receptor agonists for prolactinoma, can effectively reduce tumor size of but mechanism was not fully understood. Apoptosis had been well-recognized to contribute mass regression caused by bromocriptine. However, whether other types non-apoptotic cell death involved in bromocriptine-induced prolactinoma shrinkage clarified. The newly discovered molecular necroptosis provides possibility examine this programmed necrosis pharmacological...
In this study, we aim to evaluate the prognostic role of serum uric acid and gamma-glutamyltransferase in advanced gastric cancer patients.A total 180 patients pathologically diagnosed with were included retrospective study. We used time-dependent receiver operating characteristic (ROC) curves identify optimal cut-off value (UA) (GGT). Survival analysis was performed using Kaplan-Meier method log-rank test, multivariate Cox regression analyses applied. A nomogram formulated, calibration...
Abstract The COllaborative project of Development Anthropometrical measures in Twins (CODATwins) is a large international collaborative effort to analyze individual-level phenotype data from twins multiple cohorts different environments. main objective study factors that modify genetic and environmental variation height, body mass index (BMI, kg/m 2 ) size at birth, additionally address other research questions such as long-term consequences birth size. started 2013 open all twin projects...
Metabolic changes have been suggested to be a hallmark of tumors and are closely associated with tumorigenesis. In previous study, we demonstrated the role lactate dehydrogenase in regulating abnormal glucose metabolism pituitary adenomas (PA). As key organelle oxidative phosphorylation (OXPHOS), mitochondria play vital energy supply for tumor cells. However, few attempts made elucidate mitochondrial metabolic homeostasis PA. Dynamin-related protein 1 (Drp1) is member dynamin superfamily...
MEK, a kinase downstream of Ras and Raf oncogenes, constitutes high priority target in oncology research. MEK small molecule inhibitors cause soft tissue mineralization rats secondary to serum inorganic phosphorus (iP) elevation, but the molecular mechanism for this toxicity remains undetermined. We performed investigative studies with structurally distinct GEN-A PD325901 (PD-901) Sprague-Dawley rats. Our data support that involves FGF-23 signal blockade rat kidney, causing transcriptional...
The value of anti-angiogenesis antibody therapy in recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) remains unknown. We carried out a phase II study to evaluate the addition bevacizumab paclitaxel plus carboplatin R/M NPC.A total 80 patients with previously untreated NPC were randomly assigned (1 : 1) CPB CP groups receive (area under curve 6) and (175 mg/m2) intravenously every 3 weeks for maximum six cycles combination without (7.5 mg/kg), respectively. primary endpoint was...
Metabolic reprogramming is an important characteristic of tumors. In the progression pituitary adenomas (PA), abnormal glucose metabolism has been confirmed by us before. However, whether cholesterol involved in process PA remains unclear. This study aimed to investigate could affect PA. We analyzed expression sterol carrier protein 2 (SCP2) 40 surgical samples. vitro experiments and xenograft models were used assess effects SCP2 on proliferation The incidence hypercholesterolemia between...
Objective Many cancer cells cannot survive without exogenous glutamine (Gln); however, expressing synthetase (GS) do not have this restriction. Previous metabolomics studies indicated that metabolism is altered during pituitary tumorigenesis. However, the main role of Gln in adenoma (PA) pathophysiology remains unknown. The aim study was to evaluate expression GS and human PAs. Methods We used cell proliferation assay flow cytometry assess effect depletion on three different lines primary PA...
The invasiveness and high proliferation rate of growth hormone-secreting pituitary adenomas (GHPAs) are closely related to poor prognosis in patients. We previously reported that abnormal glycolysis participates this process; however, the role mitochondria invasion GHPAs remains unknown. In current study, stereological methods were first used quantitatively calculate number morphology mitochondria. results revealed numbers, volumes membrane areas decreased invasive (IGHPAs) samples compared...
Objective This study analyzed the prevalence, epidemiological characteristics and risk factors of birth defects among livebirths in central China, aiming to provide evidences for prevention government Decision-makings. Methods Birth data from China’s Hubei Province between 2015 2022 were collected, including basic information livebirths, mothers fathers, as well about delivery each prenatal examination. The prevalence was calculated trends mapped. evaluated by difference analysis case health...
Cervical cancer (CC) is one of the common malignant tumors in women, and incidence rate located second place female tumors. As a major RNA N6-methyladenosine (m6A) methyltransferase, methyltransferase-like 14 (METTL14) involved tumor progression by catalyzing methylation modifications mRNAs. However, molecular mechanism METTL14-mediated m6A modification CC remains not fully revealed. The expression METTL14 was detected RT-qPCR western blot. Cell function assayed cell counting kit-8 (CCK-8)...
To evaluate the prognostic value of interleukin (IL)-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), leukemia inhibitory (LIF), and macrophage migration (MIF) in non-metastatic nasopharyngeal carcinoma (NPC) patients undergoing radical radiotherapy.
e15582 Background: The aim of this study was to investigate the prevalence HPV16 infection and distribution p53 codon72 polymorphism with cervical cancer precursor lesions correlate these risk in Chinese population Hubei, China. Methods: A total 104 patients squamous-cell carcinoma (SCC) 52 intraepithelial neoplasia (CIN) II-III 88 Patients CIN I were obtained from women undergoing biopsy or surgery. examined by PCR. Results: 78.5% SCC group, 44.2% CINII- III group 16.7% group. There...
<h3>Purpose</h3> It has been found that Camk2d (calcium/calmodulin dependent protein kinase II delta) is related to E-C couple and myocardial hypertrophy heart failure in pathological states. Moreover, its function alteration may play some role arrhythmia. To further investigate the mechanism of onset development arrhythmia, we have built a platform for next stage by overexpressing cells lentivirus transduction inhibiting it RNAi. Method (1) Rat ORF was cloned PCR, ligated into vector then...
Objective To investigate the relationship between expression level of microRNA-145 (miR-145) in peripheral blood and clinicopathological characteristics esophageal cancer patients eva-luate its significance short-term efficacy radiotherapy. Methods A total 52 with diagnosed Affiliated Hospital Qingdao University were collected, all received radiotherapy alone. The relative miR-145 was detected by using method reverse transcriptase polymerase chain reaction (RT-PCR) before...